Myxoid Meningiomas of the Rostral Cervical Spinal Cord and Caudal Fossa in Four Dogs

Winkle, Thomas J. Van; Steinberg, Herman; Dayrell‐Hart, Betsy; Steinberg, Sheldon A.; Smith, Curtis A.; Summers, B. A.

doi:10.1177/030098589403100410

Cited by 12 publications

(28 citation statements)

References 8 publications

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“…One tumor was vimentin positive, whereas the other did not show vimentin expression. 10,42 Vimentin staining also was reported Van Winkle et al, 1994 48 Fernández et al, 1995 10 Yeomans …”

Section: Discussionmentioning

confidence: 82%

“…41 In a report detailing four myxoid meningiomas, two tumors displayed focal cytokeratin positivity. 48 Immunocytochemical analysis performed on impression smears of meningiomas, in which the variant was not reported, also demonstrated cytokeratin staining in focal cell clusters. 49 Thus, our data indicate that many cells in canine meningiomas will express cytokeratins in addition to vimentin.…”

Section: Discussionmentioning

confidence: 98%

“…48,49 In the human literature, numerous studies have characterized the degree of epithelial differentiation in meningiomas by use of several markers, primarily cytokeratins and EMA. Human studies have consistently reported a high level of EMA expression.…”

Section: Discussionmentioning

confidence: 99%

“…44 Additional meningeal variants that have been documented include microcystic, atypical, lipomatous, myxoid, granular cell, angioblastic, endotheliomatous, and osteomatous tumors. 11,25,40,45,48 According to WHO classification for human tumors, the lipomatous and osteomatous variants would be included in the metaplastic meningioma category. 9,27 Although the terms angioblastic and angiomatous often are used synonymously in veterinary medicine, human researchers have concluded that neoplasms previously described as angioblastic meningiomas are actually hemangiopericytomas.…”

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confidence: 99%

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Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Barnhart

Wojcieszyn²,

Storts

2002

Vet Pathol

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Abstract. This study examined immunohistochemical staining patterns for several meningioma variants involving either the brain or spinal cord of dogs. Formalin-fixed, paraffin-embedded tissue from 15 tumors was obtained. The selected tumor group included seven meningothelial, three transitional, two malignant (anaplastic), one myxoid, one papillary, and one osteomatous meningiomas. Tumors were evaluated for reactivity to the following six immunohistochemical markers: vimentin, pancytokeratin, glial fibrillary acidic protein (GFAP), S100, neuron-specific enolase (NSE), and synaptophysin. Vimentin expression was detected in all meningiomas, and 14 of 15 tumors demonstrated intense vimentin staining in more than 50% of the neoplastic cells. Pancytokeratin expression was present in 11 of 15 neoplasms; however, positive staining frequently was focal and often involved a small percentage of the neoplastic cells. GFAP expression was detected in a single, anaplastic meningioma. Although expression of NSE and S100 was detected in 12 of 25 meningiomas, the intensity of the staining and the percentage of positive neoplastic cells was highly variable. Synaptophysin was uniformly negative. These results will help to establish immunohistochemical profiles for meningiomas that will improve our ability to correctly differentiate these neoplasms of meningeal origin from central nervous system tumors originating from other sites.

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“…One tumor was vimentin positive, whereas the other did not show vimentin expression. 10,42 Vimentin staining also was reported Van Winkle et al, 1994 48 Fernández et al, 1995 10 Yeomans …”

Section: Discussionmentioning

confidence: 82%

Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Barnhart

Wojcieszyn²,

Storts

2002

Vet Pathol

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“…Este subtipo tem sido considerado com base em publicações e livros de referência mais recentes , Vandevelde et al 2012, Cantile & Youssef 2016. Anteriormente, era denominado variante mixoide (Van Winkle et al 1994), porém passou a ser chamado cordoide pelos neuropatologistas americanos pela semelhança com a variante cordoide descrita em humanos (AFIP 2008). Invasão ao parênquima foi observada nos dois casos aqui descritos, semelhantemente a outro estudo .…”

Section: Discussionunclassified

Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

et al. 2018

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Intracranial and supratentorial meningiomas were the most frequent in relation to the other intracranial or intraspinal sites. The intracranial ones were characterized mainly by clinical signs of thalamic-cortical alteration. Intraspinal ones were mainly characterized by ataxia. G-I meningiomas were the most frequent (63.6%) in dogs, followed by G-III (22.7%) and G-II (13.6%). GI were characterized by having the psammomatous subtype as the most frequent, more than one morphological pattern in the same tumor, one third presenting areas of invasion of nervous tissue, 71.4% of cases involving females, a mean age of 11 years, pure breed dogs as the most affected ones and for having the longest survival time after the manifestation of clinical signs. G-II meningiomas were characterized by having the chordoid subtype as the most frequent, invasion of nervous tissue in one third of cases, only females affected, a mean age of 12 years, two-thirds of the dogs affected were mongrels and the maximum survival time of 20 days. The G-III meningiomas were characterized by having the papillary subtype as the most frequent, invasion of the nervous tissue in 80% of the cases, 60% of the cases involving females, a mean age of 8 years, 80% of dogs affected were Boxers and the maximum survival time of 90 days. In conclusion, this study allowed to establish a relationship between the three histological grades observed in 22 cases of meningiomas in dogs with various clinical-epidemiological and pathological parameters, providing useful information for a better understanding of the correlation between the histological grading and the clinical evolution of these neoplasms.

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Tumors of the Nervous System

and¹,

Higgins²

2002

Tumors in Domestic Animals

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394

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Myxoid Meningiomas of the Rostral Cervical Spinal Cord and Caudal Fossa in Four Dogs

Cited by 12 publications

References 8 publications

Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Immunohistochemical Staining Patterns of Canine Meningiomas and Correlation with Published Immunophenotypes

Graduação histológica e aspectos clínico-patológicos relacionados em 22 meningiomas de cães

Tumors of the Nervous System

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