Myxomavirus-Derived Serpin Prolongs Survival and Reduces Inflammation and Hemorrhage in an Unrelated Lethal Mouse Viral Infection

A New Explanation of Inflammation in Rheumatoid Arthritis Patients With Respect to Claudin-5, Matrix Metalloproteinase-9, and Neuroserpin

“…In the literature, there is some evidence of a relationship between serine proteases in clot-forming (thrombotic) and clot-dissolving (thrombolytic) cascades, activated by an inflammatory cytokine storm, which can induce systemic inflammation with a loss of normal serine protease inhibitor (serpin) function. 31 In addition, NSP possesses anti-inflammatory activity in systemic arteries, modifies T helper cell responses, and significantly reduces plaque formation in mouse aortic allografts. 18 We found an association between anti-CCP/RF immunoglobulin M levels and Cld-5 in MDAG patients based on DAS28 scores.…”

Urokinase receptor-deficient mice mount an innate immune response to and clarify respiratory viruses as efficiently as wild-type mice

“…Likewise, the uPA/ uPAR system does not seem to play a relevant role in controlling viral load and inflammatory responses in a murine model of the gamma herpes virus 68 and Zaire ebola viral infections. 15 In contrast, by interacting with uPA and vitronectin, uPAR contributes to the inhibition of HIV-1 release from monocytic cells. 16,17 The cleaved and soluble form of uPAR, however, increases HIV-1 expression and blocks cell migration.…”

The Serpintine Solution

“…Serpins also control complement and immune responses, hormone transport and even blood pressure, as well as many other processes such as apoptosis, and neurohormone carriers [16][17][18][19][20][21][22][23]. In disease states such as sepsis, where there is dysregulated bleeding and clotting which is termed disseminated intravascular coagulation (DIC), there is a loss of regulation of the thrombotic and the thrombolytic cascades, both due to loss of protease functions as well as loss of serpin functions [24]. There is also evidence for abnormal serpin expression and function in cancers [25,26] and in severe inflammatory disorders [24][25][26][27].…”

“…In disease states such as sepsis, where there is dysregulated bleeding and clotting which is termed disseminated intravascular coagulation (DIC), there is a loss of regulation of the thrombotic and the thrombolytic cascades, both due to loss of protease functions as well as loss of serpin functions [24]. There is also evidence for abnormal serpin expression and function in cancers [25,26] and in severe inflammatory disorders [24][25][26][27]. Regulation of serpin control of many of enzymatic activities in diverse pathologies still needs to be properly addressed and studied.…”