n-3 Fatty acid supplementation and proresolving mediators of inflammation

Barden, Anne; Mas, Emilie; Mori, Trevor A.

doi:10.1097/mol.0000000000000262

Cited by 65 publications

(65 citation statements)

References 33 publications

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“…These are in progress, and have already given compelling evidence for the n-3 PUFA supplementation relationship to tissue resolvins and other SPM (Mas et al, 2015; Barden et al, 2016a). The further optimization of SPM profiling approaches via LC-MS-MS along with available deuterium-labeled internal and synthetic SPM standards for calculating recoveries and amounts of specific SPM family members (Colas et al, 2014; Dalli et al, 2015a; Le Faouder et al, 2013) will continue to permit rigorous interrogation of these relationships with human tissues (Elajami et al, 2016; Dalli et al, 2017b) to determine age, gender and organ-dependent levels for healthy individuals versus specific pathologic conditions.…”

Section: Functional Spm Metabolomics Enables Personalized Nutrition Amentioning

confidence: 95%

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Chiang

Serhan

2017

Molecular Aspects of Medicine

284

232

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The acute inflammatory response is host protective to contain foreign invaders. Many of today’s pharmacopeia that block pro-inflammatory chemical mediators can cause serious unwanted side effects such as immune suppression. Uncontrolled inflammation is now considered a pathophysiologic basis associated with, many widely occurring diseases such as cardiovascular disease, neurodegenerative diseases, diabetes, obesity and asthma, as well as the classic inflammatory diseases, e.g. arthritis, periodontal diseases. The inflammatory response is designated to be a self-limited process that produces a superfamily of chemical mediators that stimulate resolution of inflammatory responses. Specialized proresolving mediators (SPM) uncovered in recent years are endogenous mediators that include omega-3-derived families resolvins, protectins and maresins, as well as arachidonic acid-derived (n-6) lipoxins that stimulate and promote resolution of inflammation, clearance of microbes, reduce pain and promote tissue regeneration via novel mechanisms. Here, we review recent evidence from human and preclinical animal studies, together with the structural and functional elucidation of SPM indicating the SPM as physiologic mediators and pharmacologic agonists that stimulate resolution of inflammation and infection. These results suggest that it is time to develop immunoresolvents as agonists for testing resolution pharmacology in nutrition and health as well as in human diseases and during surgery.

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Section: Functional Spm Metabolomics Enables Personalized Nutrition Amentioning

confidence: 95%

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Chiang

Serhan

2017

Molecular Aspects of Medicine

284

232

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“…In addition to SPM production during resolution of inflammation, increasing evidence indicates that SPM are also produced in human tissues rich in omega-3 essential fatty acids [2]. For example, these tissues, to name a few, include human blood [3, 4], lymph nodes [4], human brain [5], human placenta [6], breast milk [7, 8] and human kidney [2].…”

Section: Introductionmentioning

confidence: 99%

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics

English

Norris

Hodges

et al. 2017

Prostaglandins, Leukotrienes and Essential Fatty Acids

102

117

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Specialized pro-resolving mediators (SPM), e.g. Resolvin D1, Protectin D1, Lipoxin A4, and Resolvin E1 have each shown to be active in ocular models reducing inflammation. In general, SPMs have specific agonist functions that stimulate resolution of infection and inflammation in animal disease models. The presence and quantity of SPM in human emotional tears is of interest. Here, utilizing a targeted LC-MS-MS metabololipidomics based approach we document the identification of pro-inflammatory (Prostaglandins and Leukotriene B4) and pro-resolving lipid mediators (D-series Resolvins, Protectin D1, and Lipoxin A4) in human emotional tears from 12 healthy individuals. SPMs from the Maresin family (Maresin 1 and Maresin 2) were not present in these samples. Principal Component Analysis (PCA) revealed gender differences in the production of specific mediators within these tear samples as the SPMs were essentially absent in these female donors. These results indicate that specific SPM signatures are present in human emotional tears at concentrations known to be bioactive. Moreover, they will help to further appreciate the mechanisms of production and action of SPMs in the eye, as well as their physiologic roles in human ocular disease resolution.

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“…The omega-3 fatty acid DHA produces the Resolvin D [RvD]-, Maresin [MaR]-, and Protectin [PD]-series SPM, the omega-3 fatty acid ecosapentaenoic acid (EPA) produces the Resolvin E [RvE]-series SPM, and the omega-6 fatty acid AA produces the lipoxin [LX]-series SPM [16] (FIGURE 1). The mechanism for the production of these mediators, and their role in resolution of inflammation has been detailed in previous review articles [1,15,16,18,19]. In this review, the role that SPM have in maternal-fetal health will be summarized.…”

Section: Introductionmentioning

confidence: 97%

The role of specialized pro-resolving mediators in maternal-fetal health

Elliott

Hanson

Anderson‐Berry

et al. 2017

Prostaglandins, Leukotrienes and Essential Fatty Acids

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SUMMARY Infants developing in a pro-inflammatory intrauterine environment have a significant risk for severe complications after birth. It has been shown that omega-3 fatty acids reduce inflammation, and also reduce early preterm births and decrease risk of infant admission to the neonatal intensive care unit. However, the mechanism for omega-3 fatty acids exerting these effects was previously unknown. Recent evidence has shown that downstream products of polyunsaturated fatty acids called specialized pro-resolving mediators may mediate inflammatory physiology, thus playing an important role in maternal-fetal health. In this review, current knowledge relating to specialized pro-resolving mediators in pregnancy, delivery, and perinatal disease states will be summarized.

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n-3 Fatty acid supplementation and proresolving mediators of inflammation

Cited by 65 publications

References 33 publications

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Structural elucidation and physiologic functions of specialized pro-resolving mediators and their receptors

Identification and Profiling of Specialized Pro-Resolving Mediators in Human Tears by Lipid Mediator Metabolomics

The role of specialized pro-resolving mediators in maternal-fetal health

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