2011
DOI: 10.1152/ajprenal.00064.2011
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n-3 Fatty acids block TNF-α-stimulated MCP-1 expression in rat mesangial cells

Abstract: Diaz Encarnacion MM, Warner GM, Cheng J, Gray CE, Nath KA, Grande JP. n-3 Fatty acids block TNF-␣-stimulated MCP-1 expression in rat mesangial cells.

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Cited by 28 publications
(16 citation statements)
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“…Although EPA did not influence the levels of MCP-1, it changed the composition of NF-κB. Given a previous study (Diaz Encarnacion et al, 2011), we propose that the inhibition of MCP-1 production by EPA treatment not only involves the suppression of NF-κB but also other alternative intracellular signaling pathways.…”
Section: Discussionmentioning
confidence: 45%
“…Although EPA did not influence the levels of MCP-1, it changed the composition of NF-κB. Given a previous study (Diaz Encarnacion et al, 2011), we propose that the inhibition of MCP-1 production by EPA treatment not only involves the suppression of NF-κB but also other alternative intracellular signaling pathways.…”
Section: Discussionmentioning
confidence: 45%
“…In mesangial cells, EPA inhibits platelet-derived growth factorstimulated mesangial cell mitogenesis and the cyclin D1 expression via transforming growth factor-β (28). EPA and DHA also inhibit tumor necrosis factor-α (TNF-α)-stimulated transcription of the monocyte chemo-attractant protein 1 (MCP-1) gene through interaction with signaling pathways involving extracellular signal-regulated kinase (ERK) and NF-κB (29). In vivo, fish oil treatment reduces proteinuria and mesangial activation and proliferation in anti-Thy 1.1 rats (30).…”
Section: Discussionmentioning
confidence: 99%
“…It is known that the Mediterranean diet, rich in omega-3 fatty acids, may contribute to a reduction in the MCP-1 level. Based on in vitro studies, Diaz Encarnacion et al [17] stated that EPA and DHA inhibited MCP-1 production; this may be an important mechanism of well documented anti-inflammatory properties of this group of fatty acids.…”
Section: Discussionmentioning
confidence: 99%