n‐3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro‐inflammatory mediators in Type 2 diabetes mellitus

Sampson, Michael J.; Davies, I. R.; Brown, J. C.; Morgan, Vicki; Richardson, Tristan; James, A. J.; Sampson, A. P.; Hughes, David A.

doi:10.1046/j.1464-5491.2001.00410.x

Cited by 17 publications

(9 citation statements)

References 41 publications

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“…Previous in-vitro studies in the mouse [32] and a small study in humans reported lower HLA-DR expression after fish oil, [33] but a larger study of fish oil supplementation in patients with Type 2 diabetes also showed no effect of fish oil on monocyte HLA-DR expression. [34] We found no significant correlations between HLA-DR expression on monocytes or B lymphocytes and erythrocyte EPA or DHA. However, in regression analysis the significant independent positive predictors of neonatal plasma F 2 -isoprostanes were the percentage of unstimulated monocytes expressing HLA-DR and erythrocyte AA, whilst the level of erythrocyte EPA was independently and negatively related to plasma F 2 -isoprostanes.…”

Section: Discussioncontrasting

confidence: 60%

Fish Oil Supplementation in Pregnancy Lowers F²-isoprostanes in Neonates at High Risk of Atopy

Barden

Mori

Dunstan³

et al. 2004

Free Radical Research

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The anti-inflammatory properties of n-3 polyunsaturated fatty acids (n-3 PUFA) have suggested a potential role of these nutrients in dietary modification for prevention of allergic disease in early life. As oxidative stress is known to modify antigen presenting cell (APC) signalling and resulting immune responses, we examined the effects of maternal n-3 PUFA supplementation in pregnancy on markers of oxidative stress and APC function in neonates at high risk of allergy. Eighty-three pregnant atopic women were randomised to receive 4 g daily of either fish oil (n = 40) or olive oil (n = 43) capsules in a controlled trial from 20 weeks gestation until delivery. Plasma (cord blood) and urinary F2-isoprostanes were measured as markers of lipid peroxidation. Cord erythrocyte fatty acids and markers of APC function (HLA-DR expression and cytokine responses) were measured and related to levels of plasma F2-isoprostanes. Maternal fish oil supplementation lowered plasma (p < 0.0001) and urinary (p = 0.06) F2-isoprostanes. HLA-DR expression on APC was not different between the groups. In multiple regression analysis, 28.8% of the variance in plasma F2-isoprostanes was explained by positive relationships with erythrocyte arachidonic acid (AA) and monocyte HLA-DR expression and a negative relationship with erythrocyte eicosapentaenoic acid (EPA). This study shows that maternal supplementation with fish oil can attenuate neonatal lipid peroxidation. Clinical follow-up of these infants will help to determine if there are sustained effects on postnatal oxidative stress and expression of allergic disease.

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Section: Discussioncontrasting

confidence: 60%

Fish Oil Supplementation in Pregnancy Lowers F²-isoprostanes in Neonates at High Risk of Atopy

Barden

Mori

Dunstan³

et al. 2004

Free Radical Research

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“…The findings of Abe et al show that short-term administration of omega-3 fatty acids is ineffective on vascular inflammation markers whereas long-term administration is effective as in our study. In agreement with the findings of Abe et al, Sampson et al [14 ]indicated that the administration of 2 g omega-3 fatty acids to diabetic patients for 6 weeks had no effect on serum concentrations of sICAM-1, sVCAM-1 and sE-selectin. Two other studies showed that omega-3 fatty acids were ineffective on plasma P-selectin [22,23].…”

Section: Discussionsupporting

confidence: 90%

“…The minimum sample size estimation for each group was 16 at a power of 1 – β of 90% and α = 0.05 for a two-arm parallel study with two-tailed testing to detect a difference of 95 ng/ml in serum sVCAM-1 concentration with a pooled standard deviation of 83 ng/ml, obtained from the study by Sampson et al [14]. …”

Section: Methodsmentioning

confidence: 99%

Effects of Marine Omega-3 Fatty Acids on Serum Systemic and Vascular Inflammation Markers and Oxidative Stress in Hemodialysis Patients

et al. 2011

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Background and Aims: High concentrations of serum inflammation markers, especially vascular inflammation markers, are an important risk factor for cardiovascular diseases in hemodialysis patients. The present study was designed to investigate the effects of marine omega-3 fatty acids on serum systemic and vascular inflammation markers and oxidative stress in hemodialysis patients. Methods: Thirty-four hemodialysis patients were randomly assigned to either the marine omega-3 fatty acid or the placebo group. Patients in the omega-3 fatty acid group received 2,080 mg marine omega-3 fatty acids daily for 10 weeks, whereas the placebo group received a corresponding placebo.At baseline and the end of week 10, 5 ml blood was collected after a 12- to 14-hour fast. Results: Mean serum soluble intercellular adhesion molecule type 1 (sICAM-1) decreased significantly in the omega-3 fatty acid group at the end of week 10 compared to baseline (p < 0.05) and this reduction was significant in comparison with the placebo group (p < 0.05). No significant differences were observed between the two groups in mean changes in serum soluble vascular cell adhesion molecule type 1, sE-selectin, sP-selectin, C-reactive protein, interleukin-6, tumor necrosis factor-α, malondialdehyde and total antioxidant capacity. Conclusion: The results of the present study indicate that marine omega-3 fatty acids can reduce serum sICAM-1, a risk factor for cardiovascular diseases, but it has no effect on serum systemic inflammation markers and oxidative stress in hemodialysis patients.

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“…The effects of marine n-3 fatty acids on circulating inflammatory markers among individuals with a high risk of developing CVD are shown in Table 3 [35–49] . Four of fifteen trials reported a reduction in the concentration of inflammatory markers after intake of marine n-3 fatty acids [35, 36, 45, 46], while nine studies did not observe any effects on inflammation [37–44, 48]. An increase in inflammatory markers [49] was reported in one study.…”

Section: Resultsmentioning

confidence: 99%

Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors

et al. 2011

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ObjectiveThe aim of the present paper was to review the literature in order to summarize the effects of marine n-3 fatty acids on circulating inflammatory markers among healthy subjects, subjects with high risk of developing cardiovascular disease (CVD) and in patients with CVD in human intervention studies.MethodsA systematic literature search in PubMed was performed. Intervention studies describing the effects of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects, subjects with high risk of CVD and patients with CVD were included. The following exclusion criteria were used: (1) interventions assessing inflammatory markers with ex vivo methods (2) interventions with children (3) articles describing animal or cell culture studies. Twenty-two articles were included. Additionally, 13 papers from their literature lists were included based on the same inclusion and exclusion criteria as the literature search.Results and conclusionIntervention studies with marine n-3 fatty acids administered from either fish or fish oil demonstrate different results on inflammatory markers. No firm conclusion can be drawn about the effect of marine n-3 fatty acids on circulating inflammatory markers in healthy individuals, individuals with high risk of developing CVD or individuals with CVD related diseases.

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n‐3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro‐inflammatory mediators in Type 2 diabetes mellitus

Cited by 17 publications

References 41 publications

Fish Oil Supplementation in Pregnancy Lowers F²-isoprostanes in Neonates at High Risk of Atopy

Fish Oil Supplementation in Pregnancy Lowers F²-isoprostanes in Neonates at High Risk of Atopy

Effects of Marine Omega-3 Fatty Acids on Serum Systemic and Vascular Inflammation Markers and Oxidative Stress in Hemodialysis Patients

Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors

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n‐3 polyunsaturated fatty acid supplementation, monocyte adhesion molecule expression and pro‐inflammatory mediators in Type 2 diabetes mellitus

Cited by 17 publications

References 41 publications

Fish Oil Supplementation in Pregnancy Lowers F2-isoprostanes in Neonates at High Risk of Atopy

Fish Oil Supplementation in Pregnancy Lowers F2-isoprostanes in Neonates at High Risk of Atopy

Effects of Marine Omega-3 Fatty Acids on Serum Systemic and Vascular Inflammation Markers and Oxidative Stress in Hemodialysis Patients

Effect of marine n-3 fatty acids on circulating inflammatory markers in healthy subjects and subjects with cardiovascular risk factors

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Fish Oil Supplementation in Pregnancy Lowers F²-isoprostanes in Neonates at High Risk of Atopy

Fish Oil Supplementation in Pregnancy Lowers F²-isoprostanes in Neonates at High Risk of Atopy