N-(3-Sulfo, 3-carboxy)-propionylchitosan as New Chiral Selector for Enantioresolution of Basic Drugs by Capillary Electrophoresis

Advances in chiral separation using capillary electromigration techniques

“…In another paper, the same group [48] described mechanistic studies with balhimycin in comparison to vancomycin using dansyl amino acids as model compounds. Budanova et al [49] presented N-(3-sulfo-3-carboxy)-propionylchitosan as a new chiral negatively charged selector and obtained baseline resolution with pindolol, fluoxetine, and chlorcyclizine as test compounds. Interestingly, the authors observed that the enantioselectivity of the N-(3-sulfo, 3-carboxy)propionylchitosans obtained from lowmolecular mass and high-molecular mass chitosans was similar.…”

Chiral separations by capillary electrophoresis: Recent developments and applications

“…Recently, N-(3-sulfo,3-carboxy)-propionylchitosan ( Fig. 2b) was investigated as new chiral selector by Budanova et al [63]. The mechanism of enantiorecognition of this chiral selector appeared to be somewhat different as compared to other charged polysaccharides, due to the presence of an additional chiral centre in the monosaccharide residue.…”

Electrodriven methods for the enantioseparation of second‐generation antidepressant drugs: An update

“…Among new chiral selectors, N-(3-sulfo,3-carboxy)-propionylchitosan at a concentration of 2% has allowed the complete separation of fluoxetine enantiomers when used as an additive in CZE [21], however, it was not tested on any other antidepressant. Budanova et al conclude that the chiral recognition mechanism of N-(3-sulfo-3-carboxy)-propionylchitosan is in part different from that of other charged polysaccharides, due to the presence of an additional chiral centre introduced by the addition of the 3-sulfo group.…”