Advances in chiral separation using capillary electromigration techniques

Abstract

This review gives an overview of recent developments in CZE, EKC, and CEC covering the literature since the year 2004. Since there appeared a special issue on applications, this review focuses on the progress in electromigration techniques and new methodological developments. New techniques, new chiral selectors as well as new chiral stationary phases for CEC are discussed.

Sensitive chiral analysis by CE: An update

“…A wide range of HPLC chiral stationary phases (CSPs) transferable to CEC or monolithic columns can be used to provide adequate enantioselectivity. Moreover, an important aspect from the point of view of the sensitivity and selectivity in chiral analysis is the easy coupling of CEC to MS detection, when the chiral selector in CEC is immobilized [5]. On the other hand, the aqueous buffer employed in CE is replaced in NACE by an organic solvent containing an electrolyte.…”

Pre-Concentration Approaches Combined with Capillary Electrophoresis in Bioanalysis of Chiral Cardiovascular Drugs

“…Gübitz and Schmid documented the recent progresses in chiral separation by various modes of CE. 21,26,27 MEKC is performed by solubilization of pseudostationary phase such as surfactants into BGE. CEC is a hybrid form of chromatographic and electrophoretic principles, extends the utilization of chromatographic principles to CE-based enantioseparation.…”

Chiral recognition of ethers by NMR spectroscopy

“…[12][13][14] Capillary electrophoresis is playing an increasing role as well. [15][16][17] Historically the oldest approach is monitoring the optical rotation, a method which has been developped later into a variety of chiroptical techniques, such as optical rotatory dispersion (ORD), electronic circular dichroism (ECD) or, very recently, vibrational circular dichroism (VCD). 18,19 Many other spectroscopic methods have also been introduced in the past which, however, had to overcome the drawback that they are intrinsically achiral and can be applied only if a chiral auxiliary is added during the experiment.…”