N-acetylation of toxic aromatic amines by fungi: Strain screening, cytotoxicity and genotoxicity evaluation, and application in bioremediation of 3,4-dichloroaniline

Rodrigues, Amanda Dal’Ongaro; Montanholi, Arthur dos Santos; Shimabukuro, Angela Akimi; Yonekawa, Murilo Kioshi Aquino; Cassemiro, Nadla Soares; Silva, Denise Brentan; Marchetti, Clarice Rossato; Weirich, Carlos Eduardo; Beatriz, Adilson; Zanoelo, Fabiana Fonseca; Marques, Maria Rita; Giannesi, Giovana Cristina; Neves, Silvia Cordeiro das; Oliveira, Rodrigo Juliano; Ruller, Roberto; Lima, Dênis Pires de; Santos, Edson dos Anjos dos

doi:10.1016/j.jhazmat.2022.129887

Cited by 8 publications

(6 citation statements)

References 44 publications

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“…Aspergillus sydowii and Penicillium decaturense have demonstrated the ability to degrade the organophosphate pesticide methyl parathion, converting it into p-nitrophenol [ 86 ]. Furthermore, Aspergillus niveus , Aspergillus terreus , and Cladosporium cladosporioides have successfully detoxified 3,4-dinitroaniline, a pollutant resulting from phenylurea herbicides [ 87 ]. These examples highlight the significant role of fungi in the biotransformation and degradation of pesticides, emphasizing the relevance of fungal strategies in mitigating the environmental impact of these compounds.…”

Section: Future Perspectivesmentioning

confidence: 99%

Hazards Associated with the Combined Application of Fungicides and Poultry Litter in Agricultural Areas

Corrêa-Junior,

Parente,

Frases

2024

JoX

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In recent decades, the poultry farming industry has assumed a pivotal role in meeting the global demand for affordable animal proteins. While poultry farming makes a substantial contribution to food security and nutrition, it also presents environmental and public health challenges. The use of poultry litter as fertilizer for agricultural soils raises concerns about the transfer of pathogens and drug-resistant microorganisms from poultry farms to crop production areas. On the other hand, according to the Food and Agriculture Organization of the United Nations (FAO), fungicides represent the second most used chemical group in agricultural practices. In this context, agricultural soils receive the application of both poultry litter as a fertilizer and fungicides used in agricultural production. This practice can result in fungal contamination of the soil and the development of antifungal resistance. This article explores the necessity of monitoring antifungal resistance, particularly in food production areas with co-application of poultry litter and fungicides. It also highlights the role of fungi in ecosystems, decomposition, and mutualistic plant associations. We call for interdisciplinary research to comprehensively understand fungal resistance to fungicides in the environment. This approach seeks to promote sustainability in the realms of human health, agriculture, and the environment, aligning seamlessly with the One Health concept.

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Section: Future Perspectivesmentioning

confidence: 99%

Hazards Associated with the Combined Application of Fungicides and Poultry Litter in Agricultural Areas

Corrêa-Junior,

Parente,

Frases

2024

JoX

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“…3,4-Dinitroaniline is a prominent pollutant arising from phenylurea herbicides can be successfully detoxified by fungi such as Aspergillus niveus , Aspergillus terreus , and Cladosporium cladosporioides . Rodrigues et al ( 2023 ) demonstrated that these fungi catalysed the N -acetylation of the substrate, resulting in reduced toxicity towards plants seeds and human cells. A summary of some recent examples is shown in Table 1 .…”

Section: Pesticidesmentioning

confidence: 99%

Recent advances in fungal xenobiotic metabolism: enzymes and applications

Khan,

Hof,

Niemcová

et al. 2023

World J Microbiol Biotechnol

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Fungi have been extensively studied for their capacity to biotransform a wide range of natural and xenobiotic compounds. This versatility is a reflection of the broad substrate specificity of fungal enzymes such as laccases, peroxidases and cytochromes P450, which are involved in these reactions. This review gives an account of recent advances in the understanding of fungal metabolism of drugs and pollutants such as dyes, agrochemicals and per- and poly-fluorinated alkyl substances (PFAS), and describes the key enzymes involved in xenobiotic biotransformation. The potential of fungi and their enzymes in the bioremediation of polluted environments and in the biocatalytic production of important compounds is also discussed.

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“…This study aimed to investigate the toxicity of binary mixtures of TDNMs and an organic chemical on aquatic organisms and to assess the joint effects, as well as to make quantitative predictions of the combined toxicity. 3,4-Dichloroaniline (DCA) was selected as the model compound and it is an important intermediate for a variety of pesticides, pharmaceuticals, dyes, pigments, and fine chemicals, and is also a bioactive intermediate [ 21 ]. Moreover, DCA is one of the most widely produced anilines worldwide and has been detected in freshwater, brackish, and marine environments [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

Wang

2023

IJMS

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The assessment and prediction of the toxicity of engineered nanomaterials (NMs) present in mixtures is a challenging research issue. Herein, the toxicity of three advanced two-dimensional nanomaterials (TDNMs), in combination with an organic chemical (3,4-dichloroaniline, DCA) to two freshwater microalgae (Scenedesmus obliquus and Chlorella pyrenoidosa), was assessed and predicted not only from classical mixture theory but also from structure-activity relationships. The TDNMs included two layered double hydroxides (Mg-Al-LDH and Zn-Al-LDH) and a graphene nanoplatelet (GNP). The toxicity of DCA varied with the type and concentration of TDNMs, as well as the species. The combination of DCA and TDNMs exhibited additive, antagonistic, and synergistic effects. There is a linear relationship between the different levels (10, 50, and 90%) of effect concentrations and a Freundlich adsorption coefficient (KF) calculated by isotherm models and adsorption energy (Ea) obtained in molecular simulations, respectively. The prediction model incorporating both parameters KF and Ea had a higher predictive power for the combined toxicity than the classical mixture model. Our findings provide new insights for the development of strategies aimed at evaluating the ecotoxicological risk of NMs towards combined pollution situations.

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N-acetylation of toxic aromatic amines by fungi: Strain screening, cytotoxicity and genotoxicity evaluation, and application in bioremediation of 3,4-dichloroaniline

Cited by 8 publications

References 44 publications

Hazards Associated with the Combined Application of Fungicides and Poultry Litter in Agricultural Areas

Hazards Associated with the Combined Application of Fungicides and Poultry Litter in Agricultural Areas

Recent advances in fungal xenobiotic metabolism: enzymes and applications

An Insight into the Combined Toxicity of 3,4-Dichloroaniline with Two-Dimensional Nanomaterials: From Classical Mixture Theory to Structure-Activity Relationship

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