N-acyl homoserine lactone molecules assisted quorum sensing: effects consequences and monitoring of bacteria talking in real life

Acet, Ömür; Erdönmez, Demet; Acet, Burcu Önal; Odabaşı, Mehmet

doi:10.1007/s00203-021-02381-9

Cited by 33 publications

(11 citation statements)

References 93 publications

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“…Gram-negative bacteria use AHL molecules to regulate gene expression in a population density-dependent manner ( Figure 1 ) [ 4 ]. When AHL concentrations exceed the critical detection threshold, the population is directed to coordinate the expression of target genes for diverse metabolic activities.…”

Section: Ahl Signalmentioning

confidence: 99%

“…Bacteria produce extracellular signals early in their adaptation and growth phase; as the cell density increases, the signals accumulate in the environment [ 3 ]. Once a critical cell density threshold is reached, these signals interact with their cognate receptors and coordinate the expression of associated genes [ 4 ]. In Gram-positive and Gram-negative bacteria, several QS systems have been identified [ 5 , 6 ], including acyl-homoserine lactone (AHL)-based and peptide-based QS systems.…”

Section: Introductionmentioning

confidence: 99%

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Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria

et al. 2022

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Microbial biodiversity includes biotic and abiotic components that support all life forms by adapting to environmental conditions. Climate change, pollution, human activity, and natural calamities affect microbial biodiversity. Microbes have diverse growth conditions, physiology, and metabolism. Bacteria use signaling systems such as quorum sensing (QS) to regulate cellular interactions via small chemical signaling molecules which also help with adaptation under undesirable survival conditions. Proteobacteria use acyl-homoserine lactone (AHL) molecules as autoinducers to sense population density and modulate gene expression. The LuxI-type enzymes synthesize AHL molecules, while the LuxR-type proteins (AHL transcriptional regulators) bind to AHLs to regulate QS-dependent gene expression. Diverse AHLs have been identified, and the diversity extends to AHL synthases and AHL receptors. This review comprehensively explains the molecular diversity of AHL signaling components of Pseudomonas aeruginosa, Chromobacterium violaceum, Agrobacterium tumefaciens, and Escherichia coli. The regulatory mechanism of AHL signaling is also highlighted in this review, which adds to the current understanding of AHL signaling in Gram-negative bacteria. We summarize molecular diversity among well-studied QS systems and recent advances in the role of QS proteins in bacterial cellular signaling pathways. This review describes AHL-dependent QS details in bacteria that can be employed to understand their features, improve environmental adaptation, and develop broad biomolecule-based biotechnological applications.

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Section: Ahl Signalmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria

et al. 2022

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“…The lsrB gene encodes the periplasmic AI‐2 binding protein LsrB, lsrC, and lsrD encode the channel proteins LsrC and LsrD, lsrA encodes the ATPase protein, LsrA, which provides the energy for the internalization of AI‐2. LsrK phosphorylates AI‐2 and the phosphorylated AI‐2 in turn represses LsrR expression, thereby inducing the transcription of the lsr operon [9].…”

Section: Bacterial Biofilms and Qs Signalingmentioning

confidence: 99%

Effectiveness of metal and metal oxide nanoparticles against bacterial biofilms: Perspectives and limitations

et al. 2023

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In the last few years, there has been a necessary demand in the pharmaceutical industries for finding a treatment against biofilms formed by different bacterial species. We are aware of the fact that classical processes, which are already there for the removal of bacterial biofilms gives a very low efficiency and consequently antimicrobial resistance makes it even worse. To cope up with the cited problems, scientists from the past few years are inclining toward various types of nanoparticle based treatment procedures as a pharmaceutical agent against bacterial biofilms. Nanoparticles are known for their extremely efficient antimicrobial properties. The current review gives a description of different types of metal oxide nanoparticles and their antibiofilm properties. It also shows a comparative analysis of the nanoparticles and depicts the efficiency rates of biofilm degradation in each of them. It explains the mechanism of the nanoparticles through which the disintegration of bacterial biofilm is carried out. Lastly, the review throws light upon the limitations of different nanoparticles, their safety issues, the mutagenicity, genotoxicity concerns, and toxicity hazards caused by them.

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“…The ribosome and cysteine and methionine metabolism had the highest signi cant enrichment levels (p = 0.0007). Quorum sensing plays a vital role in arranging bacterial gene regulation, participating in the regulation of bio lm formation and extracellular polymer production processes, enabling bacteria to adapt to changes in environmental conditions (Acet et al, 2021). Temperature is a signi cant factor affecting Quorum sensing (Wang et al, 2019), and a study of anaerobic ammonium oxidation bio lm reactor found that a decrease in temperature weakened quorum sensing and deteriorated nitrogen removal performance (Liu et al, 2021).…”

Section: Proteomic Expression Pro Ling and Differentially Expressed P...mentioning

confidence: 99%

Multi-omics analysis on seasonal variations of the biofilm microbial community in a full-scale pre-denitrification biofilter

Tian

Wang

Zhang

et al. 2022

Environ Sci Pollut Res

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N-acyl homoserine lactone molecules assisted quorum sensing: effects consequences and monitoring of bacteria talking in real life

Cited by 33 publications

References 93 publications

Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria

Molecular Mechanisms and Applications of N-Acyl Homoserine Lactone-Mediated Quorum Sensing in Bacteria

Effectiveness of metal and metal oxide nanoparticles against bacterial biofilms: Perspectives and limitations

Multi-omics analysis on seasonal variations of the biofilm microbial community in a full-scale pre-denitrification biofilter

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