N-Alkylation of 2-Substituted Benzimidazole Derivatives and Their Evaluation as Antinemic Agents

Benzimidazole-based ionic and non-ionic organoselenium compounds: innovative synthetic strategies, structural characterization and preliminary anti-proliferative activities

“…14 However, the synthesis of 4-nitro substituted compound 15 was unsuccessful under similar reaction conditions, and therefore, an alternative reaction strategy using aqueous boric acid was followed. 15 Subsequent N -functionalization was carried out using 1,3-dibromopropane in acetone to afford non-ionic bromides 13-2 , 14-2 and 15-2 . The bromides were further treated with KSeCN to obtain the final selenocyanates 10a–10c in satisfactory yields (Scheme 3).…”

“…Compound 15 was prepared following the reported literature method with minor modifications. 15 Briefly, 4-nitrobenzaldehyde (0.26 g, 1.73 mmol) was dissolved in distilled water (20 mL) and boric acid (2.06 g, 33.3 mmol) was added to it and stirred at room temperature for 10 minutes. Next o -phenylenediamine (compound 12 , 0.2 g, 1.85 mmol) was added to it and stirring was continued for 4 h at room temperature.…”