“…Besides these, there are several other challenges for the catalytic enantioselective C-N bond formation between indoles and carbazoles, and C-alkynyl N,O-acetals. C-alkynyl N,N-aminals have been reported to react with EtOH to form the corresponding Calkynyl N,O-acetals 61 . Thus, unlike the products generated by Cbased nucleophiles, for the products produced by N-centered nucleophiles, there is a risk of a direct conversion of newly formed C-alkynyl N,N-aminal products back to the C-alkynyl N, O-acetals (starting materials).…”