N-butyl cyanoacrylate embolotherapy: techniques, complications, and management

Hill, Hannah; Chick, Jeffrey Forris Beecham; Hage, Anthony N.; Srinivasa, Ravi N.

doi:10.5152/dir.2018.17432

Cited by 50 publications

(45 citation statements)

References 8 publications

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“…A syringe was then used to inject solution into the bioadhesive channel. Cyanoacrylate has been used extensively in surgical procedures for tissue adhesion [ 41 ] and embolization [ 42 ] and specifically has been used to secure synthetic meshes to the abdominal wall during hernia repair. [ 43 ] We therefore utilized a medical grade cyanoacrylate for fixation, and the device was allowed to bond to surrounding tissue for 5 min.…”

Section: Resultsmentioning

confidence: 99%

Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models

Duffy

Robinson

O'Connor

et al. 2020

Adv Healthcare Materials

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In article number 2000305 by Ellen T. Roche, Eimear B. Dolan, and co‐workers, a new regenerative reservoir platform (Regenervoir) is described for use in large animal models that are easily translated to human studies, with relevance to cardiac, abdominal, and soft tissue pathologies. Regenervoir incorporates multiple novel design features essential for clinical translation, with a focus on scalability, mechanism of delivery, fixation, and filling/refilling with a therapeutic cargo.

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Section: Resultsmentioning

confidence: 99%

Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models

Duffy

Robinson

O'Connor

et al. 2020

Adv Healthcare Materials

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“…On the other hand, the use of (NBCA-MS)-based glue compared with coils requires some experience to be delivered in a precise and safe manner. The adverse events described after glue embolization are basically divided in three main categories: inadvertent vascular embolization, suboptimal agent polymerization time, and catheter retention [33] . Both the suboptimal agent polymerization time and the catheter retention are related to the operator's inexperience.…”

Section: Discussionmentioning

confidence: 99%

Type III coronary perforation during chronic total occlusion percutaneous coronary interventions treated with Cyanoacrylate glue embolization: case report and review of the technique

Tumscitz¹,

Lanzillotti²,

Pirani³

et al. 2019

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In recent times the outcome of chronic total occlusion (CTO) percutaneous coronary interventions (PCI) in dedicated centers has steadily gained high success rate (> 80%) and low rate of coronary complications. Nevertheless comparing with non-CTO PCI the complications rate is higher, due to the higher lesion and technical complexity. Among the complications Type III coronary perforations remain the most troublesome events of CTO PCI and still carry a significant risk of death for the patients. The management of Type III coronary perforations has been extensively described as a flow chart of interventions and techniques to obtain rapid cessation of the blood extravasation and sealing of the ruptured vessel. Several techniques have been described to obtain bleeding cessation also in small vessel (< 2 mm) perforations.In this paper we will describe two cases of CTO PCI with Type III small vessel coronary perforations treated with percutaneous Cyanoacrylate/(NBCA-MS)-based glue infusion through a conventional CTO microcatheter. This technique is fast and straightforward and can be applied to any conventional CTO microcatheter.

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“…In situ polymerized polycyanoacrylate is another important hydrophobic polymer that has been used in several biomedical applications, most importantly as a topical tissue adhesive. Illustrating this application, n ‐butyl cyanoacrylate has been used to treat cerebral arteriovenous malformations.as an in situ polymerizing liquid embolic agent …”

Section: Chemical Phenomenamentioning

confidence: 99%

In Situ Generated Medical Devices

Cohn

Sloutski

Elyashiv

et al. 2019

Adv Healthcare Materials

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Medical devices play a major role in all areas of modern medicine, largely contributing to the success of clinical procedures and to the health of patients worldwide. They span from simple commodity products such as gauzes and catheters, to highly advanced implants, e.g., heart valves and vascular grafts. In situ generated devices are an important family of devices that are formed at their site of clinical function that have distinct advantages. Among them, since they are formed within the body, they only require minimally invasive procedures, avoiding the pain and risks associated with open surgery. These devices also display enhanced conformability to local tissues and can reach sites that otherwise are inaccessible. This review aims at shedding light on the unique features of in situ generated devices and to underscore leading trends in the field, as they are reflected by key developments recently in the field over the last several years. Since the uniqueness of these devices stems from their in situ generation, the way they are formed is crucial. It is because of this fact that in this review, the medical devices are classified depending on whether their in situ generation entails chemical or physical phenomena.

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N-butyl cyanoacrylate embolotherapy: techniques, complications, and management

Cited by 50 publications

References 8 publications

Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models

Implantable Therapeutic Reservoir Systems for Diverse Clinical Applications in Large Animal Models

Type III coronary perforation during chronic total occlusion percutaneous coronary interventions treated with Cyanoacrylate glue embolization: case report and review of the technique

In Situ Generated Medical Devices

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