N-doped carbon dot as fluorescent probe for detection of cysteamine and multicolor cell imaging

Konar, Suraj; Kumar, Bhupender; Mahto, Madhusudan Kr.; Samanta, Dibyendu; Shaik, Md Abdus Salam; Shaw, Manisha; Mandal, Mahitosh; Pathak, Amita

doi:10.1016/j.snb.2019.01.117

Cited by 89 publications

(41 citation statements)

References 60 publications

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“…Heteroatom-doping has been used by many researchers to improve the properties of C-dots [ 100 , 101 , 102 ]. The introduction of heteroatoms into the carbon atom framework can effectively regulate the electrical properties, internal and surficial chemical properties of C-dots.…”

Section: Major Factors Affecting the Properties Of C-dotsmentioning

confidence: 99%

“…Surface passivation and some other treatments enriching the surfaces of C-dots with amino, hydroxyl and carboxyl functional groups can improve the water solubility of C-dots and make the surface functionalization easier, which can lay an important foundation for extensive application of C-dots [ 109 , 110 , 111 ]. Compared with traditional semiconductor quantum dots or other nanoparticle sensors, C-dots can enter cells more easily through endocytosis due to their smaller particle size, and hence have a wider application in cell imaging and quantification of small molecules in cells [ 3 , 101 , 112 ].…”

Section: Properties Of C-dots Obtained From Biomass Wastementioning

confidence: 99%

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A Review of Carbon Dots Produced from Biomass Wastes

et al. 2020

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The fluorescent carbon dot is a novel type of carbon nanomaterial. In comparison with semiconductor quantum dots and fluorescence organic agents, it possesses significant advantages such as excellent photostability and biocompatibility, low cytotoxicity and easy surface functionalization, which endow it a wide application prospect in fields of bioimaging, chemical sensing, environmental monitoring, disease diagnosis and photocatalysis as well. Biomass waste is a good choice for the production of carbon dots owing to its abundance, wide availability, eco-friendly nature and a source of low cost renewable raw materials such as cellulose, hemicellulose, lignin, carbohydrates and proteins, etc. This paper reviews the main sources of biomass waste, the feasibility and superiority of adopting biomass waste as a carbon source for the synthesis of carbon dots, the synthetic approaches of carbon dots from biomass waste and their applications. The advantages and deficiencies of carbon dots from biomass waste and the major influencing factors on their photoluminescence characteristics are summarized and discussed. The challenges and perspectives in the synthesis of carbon dots from biomass wastes are also briefly outlined.

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Section: Major Factors Affecting the Properties Of C-dotsmentioning

confidence: 99%

Section: Properties Of C-dots Obtained From Biomass Wastementioning

confidence: 99%

A Review of Carbon Dots Produced from Biomass Wastes

et al. 2020

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“…C dots synthesized from 3‐hydroxyphenylboronic acid through a hydrothermal route were selectively quenched by fructose (LOD of 2.04 × 10 −3 m ) at pH 9.0, mainly because of the affinity of boronic‐diol on the surface of C dots toward fructose . Nitrogen‐doped C dots prepared from tartaric acid as the source of carbon and urea as nitrogen‐dopant were used for quantitation of cysteamine, with a linear concentration response of 10−210 × 10 −6 m and LOD of 75.6 × 10 −9 m . Through fluorescence resonance energy transfer, methotrexate that is a chemotherapy agent and immune system suppressant was detected using C dots prepared from Lawsonia inermis (Henna) plant, with a linear concentration range of 0.02–18 × 10 −6 m and LOD of 7 × 10 −9 m .…”

Section: Sensing and Imaging Applicationsmentioning

confidence: 99%

Recent Advances and Sensing Applications of Carbon Dots

2019

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Carbon dots (C dots) with biocompatibility, brightness, stability against photoirradiation and salt, and ease in preparation have become important materials for sensing and imaging. They can be prepared from natural materials and small organic molecules through hydrothermal, microwave‐assistant, and electrochemical methods, with advantages of simplicity and low cost. To enhance the quantum yields of C dots in the red and near‐infrared regions, doping of C dots with heteroatoms such as nitrogen and sulfur has been suggested. C dots both with and without being functionalized recognition elements such as antibodies and aptamers are selective and sensitive for sensing of analytes, including metal ions (e.g., Fe3+, Hg2+, Cu2+), small molecules (e.g., H2O2, cysteine, glutathione), and biopolymers like proteins, as well as for in vitro and in vivo imaging. Depending on the size, charge, and surface ligands of C dots used to label cells, fluorescence images of different organelles are shown. Multicolor images of bacteria, mammalian cells, and plant tissues incubated with C dots are realized when excited at different wavelengths. In this review, many excellent sensing and imaging examples of C dots are presented to highlight their features and to show their challenges for analytical applications.

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“…Post 24 h drug exposure, the cells were rinsed with 1X PBS and added with MTS reagent for 2 h. The absorbance maxima were acquired at 490 nm by utilizing the microplate reader (Cytation 5 imaging reader, BioTeK, Winooski, VT, USA). The percent viable cells were calculated as previously reported method [85][86][87][88][89] .…”

Section: Determination Of Intracellular Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells

Nagesh

Chowdhury

Hatami

et al. 2020

Sci Rep

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Prostate cancer (PCa) cells exploit the aberrant lipid signaling and metabolism as their survival advantage. Also, intracellular storage lipids act as fuel for the PCa proliferation. However, few studies were available that addressed the topic of targeting lipid metabolism in PCa. Here, we assessed the tannic acid (TA) lipid-targeting ability and its capability to induce endoplasmic reticulum (ER) stress by reactive oxygen species (ROS) in PCa cells. TA exhibited dual effects by inhibiting lipogenic signaling and suppression of lipid metabolic pathways. The expression of proteins responsible for lipogenesis was down regulated. The membrane permeability and functionality of PCa were severely affected and caused nuclear disorganization during drug exposure. Finally, these consolidated events shifted the cell's survival balance towards apoptosis. These results suggest that TA distinctly interferes with the lipid signaling and metabolism of PCa cells.

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N-doped carbon dot as fluorescent probe for detection of cysteamine and multicolor cell imaging

Cited by 89 publications

References 60 publications

A Review of Carbon Dots Produced from Biomass Wastes

A Review of Carbon Dots Produced from Biomass Wastes

Recent Advances and Sensing Applications of Carbon Dots

Tannic acid inhibits lipid metabolism and induce ROS in prostate cancer cells

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