N-Heteroaryl glycinamides and glycinamines as potent NPY5 antagonists

Wu, Lingyun; Lǚ, Kai; Desai, Mahesh; Packiarajan, Mathivanan; Joshi, Amita; Marzabadi, Mohammad R.; Jubian, Vrej; Andersen, Kim; Chandrasena, Gamini; Boyle, Noel J.; Walker, Mary W.

doi:10.1016/j.bmcl.2011.06.078

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Drugs For Central Nervous Diseases1

Seven-membered Heterocycles With Two Heteroatoms1

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Cited by 8 publications

(2 citation statements)

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“…This class of compounds shows promising therapeutic potential as a CB1 receptor antagonist for the treatment of obesity. Wu et al 69 were interested in the identification of new antagonists for the NPY5 (Neuropeptide Y 5) receptor, which is involved in many different biological functions of the central and peripheral nervous systems. For example NPY5 antagonists may be useful in controlling food intake and treating obesity.…”

Section: Drugs For Central Nervous Diseasesmentioning

confidence: 99%

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

et al. 2013

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Section: Drugs For Central Nervous Diseasesmentioning

confidence: 99%

Microwave-assisted synthesis of N-heterocycles in medicinal chemistry

et al. 2013

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“…To overcome this difficulty, Wu and coworkers designed and synthesized [99] microwave-assisted cyclization of 2-aminothiophenol with methacrylate derivatives to afford benzothiazepinones (98). Neuropeptide Y type 5 (NPY5) receptor is one of the five subtypes of NPY receptors, which are a class of G protein-coupled receptors.…”

Section: Seven-membered Heterocycles With Two Heteroatomsmentioning

confidence: 99%