N-Heterocyclic carbene catalyzed synthesis of benzotrifluorides from enals and β-trifluoromethylenones

Abstract

An NHC-catalyzed benzannulation reaction of enals and β-trifluoromethylenones is developed for the synthesis of benzotrifluorides.

A photoinduced multicomponent intramolecular cyclization/hydroxytrifluoromethylation cascade: facile access to polyfunctionalized 3,4-dihydroquinazolinones

“…7 Trifluoromethyl (CF 3 )-modified N-heterocycles, in particular, have recently attracted increasing attention due to their advantageous qualities, including improved physicochemical profiles, metabolic stability, and membrane permeability. 8 Such scaffolds display a wide spectrum of biological activities, spanning anticancer, anti-HIV, and antiarrhythmic effects, and have emerged as privileged structures in medicinal chemistry 9 (Fig. 1a).…”