N lines in a myopathy with myosin loss

Lopate, Glenn; Pestronk, Alan; Yee, Woon Chee

doi:10.1002/(sici)1097-4598(199809)21:9<1216::aid-mus17>3.0.co;2-p

Cited by 4 publications

(2 citation statements)

References 15 publications

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“…Moreover, muscle atrophy occurs in other expiratory muscles, including the obliquus interna, obliquus externa, transversus abdominis, and rectus abdominis muscles [63]. In the case report of a mechanically ventilated patient, intercostal muscle biopsy showed the loss of myosin-containing thick filaments, with the possible detachment of titin [64]. Titin loss may be an important cause of other respiratory muscle dysfunctions, as well as that of the diaphragm.…”

Section: Other Respiratory Muscle Atrophymentioning

confidence: 99%

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Nakanishi

Tsutsumi

Hara

et al. 2021

JCM

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Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interconnects the contraction of actin-containing thin filaments and myosin-containing thick filaments. Titin breaks down to form urinary titin N-fragments, which are measurable in urine. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies have reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.

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Section: Other Respiratory Muscle Atrophymentioning

confidence: 99%

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Nakanishi

Tsutsumi

Hara

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

“…Moreover, muscle atrophy occurs in other expiratory muscles including the obliquus interna, obliquus externa, transversus abdominis, and rectus abdominis muscles [43]. In a case report of a mechanically ventilated patient, intercostal muscle biopsy showed the loss of myosincontaining thick filaments with the possible detachment of titin [44]. Titin loss may be an important cause of other respiratory muscle dysfunctions as well as that of the diaphragm.…”

Section: Other Respiratory Muscle Atrophymentioning

confidence: 99%

Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Nakanishi¹,

Tsutsumi²,

Hara³

et al. 2020

Preprint

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Titin is a giant protein that functions as a molecular spring in sarcomeres. Titin interplays the contraction of actin-containing thin filaments and myosin-containing thick filaments. The breakdown product of titin has been measurable in urine as urinary titin N-fragments. Urinary titin N-fragment was originally reported to be a useful biomarker in the diagnosis of muscle dystrophy. Recently, the urinary titin N-fragment has been increasingly gaining attention as a novel biomarker of muscle atrophy and intensive care unit-acquired weakness in critically ill patients, in whom titin loss is a possible pathophysiology. Furthermore, several studies reported that the urinary titin N-fragment also reflected muscle atrophy and weakness in patients with chronic illnesses. It may be used to predict the risk of post-intensive care syndrome or to monitor patients’ condition after hospital discharge for better nutritional and rehabilitation management. We provide several tips on the use of this promising biomarker in post-intensive care syndrome.

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The Big Eye in the 21st Century: The Role of Electron Microscopy in Modern Diagnostic Neuropathology

Mrak

2002

J Neuropathol Exp Neurol

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Electron microscopy (EM) remains a powerful and even essential tool in modern diagnostic neuropathology. tumors are still encountered that defy histological or immunohistochemical classification, and EM can often provide answers in these cases. Tumors of the CNS for which EM is useful include unusual or atypical variants of meningioma, ependymoma, and schwannoma; oligodendroglioma-like tumors composed of small "clear" cells; and small "blue cell" tumors of childhood. EM is of great value in identifying site of origin for metastatic adenocarcinomas of unknown origin-an under-recognized and under-utilized potential for this technique. EM is useful in the diagnosis of peripheral nerve sheath tumors and gastrointestinal autonomic nerve tumors. EM is also important in the evaluation of certain congenital, inherited and metabolic diseases-including ceroid lipofuscinoses, CADASIL syndrome, certain myopathies, and mitochondrial encephalomyopathies--and of certain toxic and drug-induced peripheral neuropathies. An important application of EM is its utility in initiating a workup of an atypical tumor or metabolic condition, for which clinical and histological clues point in no obvious direction. In these situations, EM may provide either an answer outright (including answers to questions not asked) or important clues that guide further workup and narrow the range of diagnostic possibilities.

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N lines in a myopathy with myosin loss

Cited by 4 publications

References 15 publications

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Urinary Titin N-Fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

Urinary Titin N-fragment as a Biomarker of Muscle Atrophy, Intensive Care Unit-Acquired Weakness, and Possible Application for Post-Intensive Care Syndrome

The Big Eye in the 21st Century: The Role of Electron Microscopy in Modern Diagnostic Neuropathology

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