N-monosubstituted 6-Aminomethylene-5-oxo-2-phenyl-5,6,7,8-tetrahydroquinazolines

Die Vogelwelt von La Graciosa

“…The standard conditions of AcOH‐EtOH are often reported for similar type of cyclization reactions of anilines leading to dibenzo[b,e][1,4]diazepines [2, 4]. Therefore, these conditions were studied initially.…”

“…Consequently, syntheses of benzodiazepine derivatives or diazepine‐containing heterocycles are of interest to organic and medicinal chemists. Thus, dibenzo[b,e][1,4]diazepines and other tricyclic systems with a 1,4‐diazepine moiety are well documented in the literature [2–9].…”

Novel Enamine Derivatives of 5,6-Dihydro-2′-Deoxyuridine Formed in Reductive Amination of 5-Formyl-2′-Deoxyuridine

“…Similar effect of the intramolecular H-bonding was observed for many compounds with analogous enaminone functionality, for example, in the products derived from reactions of 3-formylchromones with amino compounds [16] and for 6-aminomethylene derivatives of 5-oxo-2-phenyl-5,6,7,8-tetrahydroquinazoline. [17] Although the reduction with NaBH(OAc) 3 is not selective toward conjugated double bond system of 2a, it is worth to mention that the transformation of aldehyde 1 to amino-modified nucleosides 3 and 4 is almost quantitative. To the best of our knowledge, the dihydrouridine derivative of 4a structure has not been described in the literature to date.…”

Graphene‐mesoporous anatase TiO2 nanocomposite: A highly efficient and recyclable heterogeneous catalyst for one‐pot multicomponent synthesis of benzodiazepine derivatives

“…After confirmation of the formation of the intermediate by TLC, aromatic aldehyde 3a–e (1 mmol) was added and the reaction was continued for the appropriate length of time (Table ). After completion, the reaction was monitored through TLC for the purity and the catalyst was recovered from the mixture using filtration, washed with ethylacetate (3 × 5 ml) and reused for successive runs . The filtrate was concentrated to furnish products 4a–j , which were then further purified by recrystallization from methanol.…”