N,N‑dimethylformamide‑induced acute hepatic failure: A case report and literature review

Lei, Yuanli; Xiao, Shasha; Chen, Shouquan; Zhang, Haiyan; Li, Huiping; Lu, Yingru

doi:10.3892/etm.2017.5213

Cited by 8 publications

(8 citation statements)

References 15 publications

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“…Unfortunately, the former is definitely problematic from the environmental impact perspective. In general, DMF is considered a toxic compound causing hepatic disorders [ 113 ]. Although DMSO is much less hazardous, and is by some studies considered a green solvent [ 114 , 115 , 116 ], there are reports on its side effects indicating the need for its replacement with greener alternatives [ 117 , 118 ].…”

Section: Resultsmentioning

confidence: 99%

New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide

et al. 2022

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New protocol for screening efficient and environmentally friendly solvents was proposed and experimentally verified. The guidance for solvent selection comes from computed solubility via COSMO-RS approach. Furthermore, solute-solvent affinities computed using advanced quantum chemistry level were used as a rationale for observed solvents ranking. The screening protocol pointed out that 4-formylomorpholine (4FM) is an attractive solubilizer compared to commonly used aprotic solvents such as DMSO and DMF. This was tested experimentally by measuring the solubility of the title compounds in aqueous binary mixtures in the temperature range between 298.15 K and 313.15 K. Additional measurements were also performed for aqueous binary mixtures of DMSO and DMF. It has been found that the solubility of studied aromatic amides is very high and quite similar in all three aprotic solvents. For most aqueous binary mixtures, a significant decrease in solubility with a decrease in the organic fraction is observed, indicating that all systems can be regarded as efficient solvent-anti-solvent pairs. In the case of salicylamide dissolved in aqueous-4FM binary mixtures, a strong synergistic effect has been found leading to the highest solubility for 0.6 mole fraction of 4-FM.

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Section: Resultsmentioning

confidence: 99%

New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide

et al. 2022

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“… 14 15 16 There are many human mortality cases of DMF induced hepatotoxicity ranging from acute liver failure to decompensated liver cirrhosis, though most of the DMF-induced liver damage is recovered. 17 18 19 20 …”

Section: Discussionmentioning

confidence: 99%

A Case of Autoimmune Hepatitis after Occupational Exposure to N,N-Dimethylformamide

et al. 2020

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N,N-dimethylformamide (DMF), a widely used solvent in the chemical industry, is known to induce toxic hepatitis. However, there have been no reported cases of DMF-associated autoimmune hepatitis. A 31-year-old healthy man working at a glove factory since July 2015 had intermittently put his bare hands into a diluted DMF solution for his first 15 days at work. After 2 months, he felt nausea, fatigue, and hand cramping, and a jaundice followed. His laboratory findings showed positive autoantibodies and elevated immunoglobulin G (IgG), and his liver biopsy pathology was typical of autoimmune hepatitis (AIH). Prednisolone and azathioprine therapy began, and he recovered rapidly without adverse events. Though his liver chemistry was normalized, the IgG level remained persistently upper normal range. His 2nd liver biopsy performed in April 2019 showed mild portal activity, and he was well under a low dose immunosuppressive therapy up to April 2020. This case warns of the hazard of occupational exposure to DMF, and clinicians should be aware of DMF-related AIH for timely initiation of immunosuppressive therapy.

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“…The laboratory data indicated the following: White blood cells, 16.72×10 9 /l (normal range, 3.50–9.50×10 9 /l); D-Dimer: >20 mg/l (normal range, 0.00–0.50 mg/l); bicarbonate, 14.9 mmol/l (normal range, 21.4–27.3 mmol/l); and urine ketone body, strong positive (normal range: Negative). Normal values were described previously ( 12 – 14 ). Amylase, troponin I, aminotransferase, creatinine, brain natriuretic peptide, blood pH and PaO 2 were all normal.…”

Section: Case Reportmentioning

confidence: 99%

Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review

et al. 2018

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In acute aortic dissection (AD) in pregnancy, increased cardiovascular stress due to pregnancy is an important factor leading to an emergent aortic event. It is rare but often results in a devastating event for both the pregnant patient and the foetus. Two cases of acute AD (Stanford type A) in pregnant females are presented in the present study. The patients were diagnosed via echocardiography, and the diagnosis was confirmed with computed tomography angiography prior to aortic surgery. Up to 50% of ADs in pregnancy occur in patients with fibrillin-1 (FBN1) gene mutations. The FBN1 gene was sequenced in both patients, and notable, novel pathogenic mutations of FBN1 were identified in both patients. A literature review was also performed on available diagnostic imaging and other measurements regarding AD during pregnancy. The authors suggest that the relevant content may have important clinical implications in raising disease awareness, arranging test rationally and choosing an intervention method.

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N,N‑dimethylformamide‑induced acute hepatic failure: A case report and literature review

Cited by 8 publications

References 15 publications

New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide

New Screening Protocol for Effective Green Solvents Selection of Benzamide, Salicylamide and Ethenzamide

A Case of Autoimmune Hepatitis after Occupational Exposure to N,N-Dimethylformamide

Type A aortic dissection in pregnant patients with fibrillin‑1 gene mutations: Two case reports and a literature review

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