A Case of Autoimmune Hepatitis after Occupational Exposure to N,N-Dimethylformamide

Jang, Boo Ok; Choi, Gwang Hyeon; Jang, Hee Yoon; Ahn, Soomin; Choi, Jae Kyun; Kim, Si-Ho; Lee, Kyunghan; Jang, Eun Sun; Kim, Jin Wook; Jeong, Sook Hyang

doi:10.3346/jkms.2020.35.e228

Cited by 9 publications

(3 citation statements)

References 15 publications

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“…However, the effect of osmotic stress on brain physiology still remains unclear. Numerous brain vascular chips have been developed to study pathogenic brain infection, [ 21b ] neurodegeneration, [ 21a,48 ] and glioblastoma. [ 49 ] In this regard, osmolarity modulation in the brain vasculature models would be a powerful approach to further elucidate the effect of osmotherapy on brain pathophysiology.…”

Section: Discussionmentioning

confidence: 99%

Mechanobiological Adaptation to Hyperosmolarity Enhances Barrier Function in Human Vascular Microphysiological System

et al. 2023

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In infectious disease such as sepsis and COVID‐19, blood vessel leakage treatment is critical to prevent fatal progression into multi‐organ failure and ultimately death, but the existing effective therapeutic modalities that improve vascular barrier function are limited. Here, this study reports that osmolarity modulation can significantly improve vascular barrier function, even in an inflammatory condition. 3D human vascular microphysiological systems and automated permeability quantification processes for high‐throughput analysis of vascular barrier function are utilized. Vascular barrier function is enhanced by >7‐folds with 24–48 h hyperosmotic exposure (time window of emergency care; >500 mOsm L−1) but is disrupted after hypo‐osmotic exposure (<200 mOsm L−1). By integrating genetic and protein level analysis, it is shown that hyperosmolarity upregulates vascular endothelial‐cadherin, cortical F‐actin, and cell–cell junction tension, indicating that hyperosmotic adaptation mechanically stabilizes the vascular barrier. Importantly, improved vascular barrier function following hyperosmotic exposure is maintained even after chronic exposure to proinflammatory cytokines and iso‐osmotic recovery via Yes‐associated protein signaling pathways. This study suggests that osmolarity modulation may be a unique therapeutic strategy to proactively prevent infectious disease progression into severe stages via vascular barrier function protection.

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Section: Discussionmentioning

confidence: 99%

Mechanobiological Adaptation to Hyperosmolarity Enhances Barrier Function in Human Vascular Microphysiological System

et al. 2023

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“…A 35-year-old patient working in a glove manufacturing factory exposed to dimethylformamide solution with bare hands and developing autoimmune hepatitis was reported. [13] In an experimental animal study, mice were given 1.26 g/kg DMF for 90 days. Pathological examinations on the livers of mice showed hypertrophy and swelling in their hepatocytes, and inflammatory cell infiltration in the liver was also demonstrated.…”

Section: Tetrachlorethylene and Perchlorethylenementioning

confidence: 99%

Work-Related and Occupational Liver Diseases

Yurt

2023

EJMA

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D efinition of occupational diseases in the legislation; are the cases of temporary or permanent illness, physical or mental disability, which the insured suffers due to a recurring reason due to the nature of the work or the performance of the work. [1] Occupational diseases are diseases in which many causative factors and other risk factors play a role in the workplace. Etiology is complex. The causative agent of the disease does not have to be in the workplace. Occupational diseases are diseases in which many causative factors and other risk factors play a role in the workplace. Etiology is complex. Occupation causes, aggravates, accelerates or exacerbates illness and may reduce working capacity. Occupational diseases are more common than occupational diseases. Even if they do not arise directly from the workplace, they are affected by factors in the workplace. [2] The liver has many functions in the detoxification of toxins, alcohol and drugs in the blood, and in processing, synthesizing and storing various carbohydrates, lipids, proteins, vitamins and minerals. [3] Many factors such as alcohol addiction, various drugs, diets and systemic diseases such as heart failure, viral hepatitis, industrial chemicals such as occupational vinyl chloride, fungi containing hepatotoxins (amatoxin) (Amanita phalloides and Amanita verna) cause liver damage. [4] Occupational liver diseases may develop due to acute high dose and chronic low dose exposures in the workplace. While acute high-dose exposure is easy to define, the cause can be difficult to identify in low-dose chronic exposure. Epidemiological data in occupational liver diseases are insufficient. The limited awareness of hepatologists, the absence of pathognomonic findings for diagnosis, the absence of a sensitive biomarker, and the accompanying many other factors make it difficult to diagnose occupational liver disease. [5] According to the factor causing occupational disease; chemical causes, physical causes, biological causes and dusts. According to the factor causing occupational disease; chemical causes, physical causes, biological causes and dusts. In this article; The aim is to draw attention to occupational factors in liver diseases by classifying them according to factors and examining various reviews, research and case reports. It is to evaluate whether people with liver disease are exposed to these factors, to prevent exposure if there is, and to protect healthy workers in the same environment from this exposure.The liver is an organ responsible for the metabolism of drugs, many chemicals and various nutrients in the body. For this reason, it is inevitable that the liver will be affected by many factors that are exposed at work. Epidemiological data on occupational liver diseases are insufficient. It is always important to take an occupational anamnesis and evaluate the risks exposed while evaluating liver functions in periodic examinations at work, in hospital polyclinics.

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“…For instance, they exchange information regarding the number of supported links, their ability to perform STR, their transmission operation (asynchronous or synchronous), and other per-link information (e.g., frequency band, supported bandwidth, number of spatial streams, etc.) [16], [17]. To reduce overhead, the described multi-link setup process is proposed to be performed only on a single link, which, indeed, will be the lowest in frequency due to propagation constraints.…”

Section: Multi-link Operation: An Overviewmentioning

confidence: 99%

IEEE 802.11be Multi-Link Operation: When the Best Could Be to Use Only a Single Interface

López-Raventós

Bellalta

2021

2021 19th Mediterranean Communication and Computer Networking Conference (MedComNet)

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The multi-link operation (MLO) is a new feature proposed to be part of the IEEE 802.11be Extremely High Throughput (EHT) amendment. Through MLO, access points and stations will be provided with the capabilities to transmit and receive data from the same traffic flow over multiple radio interfaces. However, the question on how traffic flows should be distributed over the different interfaces to maximize the WLAN performance is still unresolved. To that end, we evaluate in this article different traffic allocation policies, under a wide variety of scenarios and traffic loads, in order to shed some light on that question. The obtained results confirm that congestion-aware policies outperform static ones. However, and more importantly, the results also reveal that traffic flows become highly vulnerable to the activity of neighboring networks when they are distributed across multiple links. As a result, the best performance is obtained when a new arriving flow is simply assigned entirely to the emptiest interface.

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A Case of Autoimmune Hepatitis after Occupational Exposure to N,N-Dimethylformamide

Cited by 9 publications

References 15 publications

Mechanobiological Adaptation to Hyperosmolarity Enhances Barrier Function in Human Vascular Microphysiological System

Mechanobiological Adaptation to Hyperosmolarity Enhances Barrier Function in Human Vascular Microphysiological System

Work-Related and Occupational Liver Diseases

IEEE 802.11be Multi-Link Operation: When the Best Could Be to Use Only a Single Interface

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