In the present study,
a green and ecofriendly nanocatalyst was
synthesized through functionalization of 2,4,6-trichloro-1,3,5-triazine
(TCT) and mesalamine on silica-coated magnetic nanoparticles (MNPs),
then coordination with Cu
2+
without agglomeration, consecutively.
The silica-coated MNPs functionalized with the Cu(*II)–mesalamine
complex was (Fe
3
O
4
@SiO
2
@NH
2
-TCT-mesalamine–Cu(II) MNPs) completely characterized by FT-IR,
XRD, EDX, FESEM, TEM, VSM, TGA, and BET analyses. Afterward, the activity
of the novel catalyst was investigated in the synthesis of chromene
heterocycles, which were an important group of organic compounds.
The activity of Fe
3
O
4
@SiO
2
@NH
2
-TCT-mesalamine–Cu(II) MNPs as a high-performance heterogeneous
nanocatalyst was evaluated for the synthesis of 2-amino-4-aryl-6-(phenylthio)pyridine-3,5-dicarbonitriles
and 2-amino-4
H
-chromenes via aromatic aldehydes,
malononitrile, and enolizable C–H acids (resorcinol, 2-hydroxynaphthalene-1,4-dione,
and benzenethiol) in ethanol under reflux conditions. Fe
3
O
4
@SiO
2
-TCT-mesalamine–Cu(II) could
be quickly separated using an external magnet and reused nine times
without a remarkable reduction of its catalytic activity.