N,N,N-Trimethyl chitosan: An advanced polymer with myriad of opportunities in nanomedicine

Kulkarni, Abhijeet D.; Patel, Harun; Surana, Sanjay J.; Vanjari, Yogesh H; Belgamwar, Veena S.; Pardeshi, Chandrakantsing V.

doi:10.1016/j.carbpol.2016.10.041

Cited by 133 publications

(83 citation statements)

References 145 publications

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“…TMC can be synthesized by two methods. One method is direct quaternary ammonium substitution ( Figure 5A) [71,72], and the other is the N-alkylation method ( Figure 5B) [73][74][75]. The epoxy-derivative ring-opening process is the reaction of C 2 -NH 2 with GTA or CTA under alkaline conditions.…”

Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

“…Compared with viral vectors, non-viral vectors feature an ease of production, high yield, and low cost, and they can be widely used for drug delivery [174][175][176][177][178]. Chitosan derivative nanoparticles, as non-viral vectors, have excellent solubility, biodegradability, biocompatibility, non-toxicity, and a higher transfection rate than chitosan nanoparticles [73,98,179]. Table 3 shows a gene delivery carrier-containing a chitosan derivative and its applications.…”

Section: Chitosan Derivative Nanoparticles For the Delivery Of Genementioning

confidence: 99%

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Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

649

326

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Chitosan is a product of the deacetylation of chitin, which is widely found in nature. Chitosan is insoluble in water and most organic solvents, which seriously limits both its application scope and applicable fields. However, chitosan contains active functional groups that are liable to chemical reactions; thus, chitosan derivatives can be obtained through the chemical modification of chitosan. The modification of chitosan has been an important aspect of chitosan research, showing a better solubility, pH-sensitive targeting, an increased number of delivery systems, etc. This review summarizes the modification of chitosan by acylation, carboxylation, alkylation, and quaternization in order to improve the water solubility, pH sensitivity, and the targeting of chitosan derivatives. The applications of chitosan derivatives in the antibacterial, sustained slowly release, targeting, and delivery system fields are also described. Chitosan derivatives will have a large impact and show potential in biomedicine for the development of drugs in future.

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Section: Quaternary Ammonium Chitosanmentioning

confidence: 99%

Section: Chitosan Derivative Nanoparticles For the Delivery Of Genementioning

confidence: 99%

Chitosan Derivatives and Their Application in Biomedicine

Wang

Meng

et al. 2020

IJMS

649

326

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“…Additional lipophilic groups were described to greatly increase biocompatibilty [178,179]. COS and associated derivatives were reported for their uses in DNA/drug delivery system, [180], tissue regeneration [177], anticancer/antitumor [180], anti-HIV(1) [181], anti-hypertensive [180], or Alzheimer's disease [182]. N,N,N-trimethyl CS (TMC) was reported as a quaternized hydriophilic derivative for assembling new pharmacaeutical nano-structures [182], but also for applications in tissue engineering [183].…”

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

“…COS and associated derivatives were reported for their uses in DNA/drug delivery system, [180], tissue regeneration [177], anticancer/antitumor [180], anti-HIV(1) [181], anti-hypertensive [180], or Alzheimer's disease [182]. N,N,N-trimethyl CS (TMC) was reported as a quaternized hydriophilic derivative for assembling new pharmacaeutical nano-structures [182], but also for applications in tissue engineering [183]. These authors prepared a multifunctional nanohybrid scaffold able, on one hand, to in vitro load/release bioactive molecules (e.g., LMW heparin), and on the other hand, to play the role of a platform for the proliferation of soft tissue, extracellular matrix, and specific cells involved in adipogenesis.…”

Section: Biomedical and Pharmaceutical Functionsmentioning

confidence: 99%

Modification of Chitosan for the Generation of Functional Derivatives

et al. 2019

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Today, chitosan (CS) is probably considered as a biofunctional polysaccharide with the most notable growth and potential for applications in various fields. The progress in chitin chemistry and the need to replace additives and non-natural polymers with functional natural-based polymers have opened many new opportunities for CS and its derivatives. Thanks to the specific reactive groups of CS and easy chemical modifications, a wide range of physico-chemical and biological properties can be obtained from this ubiquitous polysaccharide that is composed of β-(1,4)-2-acetamido-2-deoxy-d-glucose repeating units. This review is presented to share insights into multiple native/modified CSs and chitooligosaccharides (COS) associated with their functional properties. An overview will be given on bioadhesive applications, antimicrobial activities, adsorption, and chelation in the wine industry, as well as developments in medical fields or biodegradability.

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“…The excellent properties offered by chitosan provide it a significant edge for nanoparticle formation over other nanocarrier materials [8]. Some strategies have been used to increase the adhesion and penetration of drugs through the vaginal mucosa.…”

Section: Coating or Gel Vehicle For Drug Deliverymentioning

confidence: 99%