N,N,N-trimethyl chitosan as an efficient antibacterial agent for polypropylene and polylactide nonwovens

Stawski, Dawid; Sahariah, Priyanka; Hjálmarsdóttir, Martha Á.; Wojciechowska, Dorota; Puchalski, Michał; Másson, Már

doi:10.1080/00405000.2016.1218594

Cited by 14 publications

(4 citation statements)

References 19 publications

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“…66 Moreover, the leaching of the antimicrobial agent would occur in PLA/Ag, 62 PLA/CNC/Ag, 63 PLA/ZnO, 64,65 and PLA/PDMAEMA/Cu. 67,68 In this work, nonleaching and high-efficiency antibacterial PLA-based nanocomposites were prepared simultaneously. Compared with nonleaching antimicrobial HMPDLA/PLLA-b-PDMAEMA fibrous mats, 69−71 the content of the antimicrobial agent in our PDLA/ZnO-g-PLLA nanocomposites is up to 30 times lower while maintaining similar antimicrobial activity.…”

Section: ■ Results and Discussionmentioning

confidence: 99%

Smart Design of Rapid Crystallizing and Nonleaching Antibacterial Poly(lactide) Nanocomposites by Sustainable Aminolysis Grafting and in Situ Interfacial Stereocomplexation

et al. 2018

ACS Sustainable Chem. Eng.

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Sustainable antibacterial poly(lactide) (PLA) nanocomposites have attracted plenty of attention due to their potential application in biomedical and packaging fields. However, the preparation of nonleaching antibacterial PLA nanocomposites with high crystallinity is still a challenge due to their poor compatibility and the low crystallization rate of PLA. An effective and facile way by compounding poly(d-lactide) (PDLA) with poly(l-lactide) (PLLA)-grafted ZnO that was synthesized via in situ aminolysis reaction at the surface of ZnO was designed to simultaneously overcome these limitations. During solution mixing, the PDLA matrix and the grafted PLLA chains tend to orient side by side at the PDLA/ZnO interface and finally cocrystallize into stereocomplex (sc) crystallites. The interfacial stereocomplexation not only serves as a nucleator to increase the crystallization rate of the matrix but also effectively prevents ZnO from leaching out of the polymer matrix. Meanwhile, the nanocomposites have excellent biocompatibility. Therefore, it may provide an effective route to prepare advanced PLA-based materials with a fast crystallization rate, excellent biocompatibility, and nonleaching antibacterial property in this work, thus broadening the application range of PLA in biomedical applications.

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Section: ■ Results and Discussionmentioning

confidence: 99%

Smart Design of Rapid Crystallizing and Nonleaching Antibacterial Poly(lactide) Nanocomposites by Sustainable Aminolysis Grafting and in Situ Interfacial Stereocomplexation

et al. 2018

ACS Sustainable Chem. Eng.

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“…The procedure for the N , N , N -trimethylation of chitosan has been previously reported [20,28,29]. By repeated methylation reactions a product with a very high degree of trimethylation (quaternization) and a low degree of O-methylation was obtained.…”

Section: Discussionmentioning

confidence: 99%

The Effect of Molecular Weight on the Antibacterial Activity of N,N,N-Trimethyl Chitosan (TMC)

Sahariah

Cibor

Zielińska

et al. 2019

IJMS

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N,N,N-trimethyl chitosan (TMC) with 93% degree of trimethylation was synthesized. TMC and the chitosan starting material were subjected to acidic hydrolysis to produce 49 different samples with a reduced average molecular weight (Mw) ranging from 2 to 144 kDa. This was done to allow the investigation of the relationship between antibacterial activity and Mw over a wide Mw range. NMR investigation showed that hydrolysis did not affect the degree of trimethylation (DSTRI) or the structure of the polymer backbone. The activity of TMC against Staphylococcus aureus (S. aureus) increased sharply with Mw until a certain Mw value (critical Mw for high activity, CMW) was reached. After the CMW, the activity was not affected by a further increase in the Mw. A similar pattern of activity was observed for chitosan. The CMW was determined to be 20 kDa for TMC and 50 kDa for chitosan.

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“…Dodecenyl succinylated phthaloyl chitosan B. subtilis, S. aureus, E. coli [ 103] N, N, N-trimethyl chitosan-polylactide S. aureus [104] Chitosan-sulfonamide derivatives S. aureus, E. coli [ 105] N-succinyl chitosan E. coli and S. aureus [ 106] Carboxymethylated chitosan E. coli [ 107] Aldehyde chitosan E. coli [ 108] N-Aminorhodanine modified chitosan/copper ions Staph. strain [ 109] Carboxymethyl chitosan/ZnO nanocomposite S. aureus, E. coli [ 110] Hydroxypropyltrimethylammonium chloride CS…”

Section: Chitosan Derivatives Microbementioning

confidence: 99%

Chitosan‐Based Hydrogels for Infected Wound Treatment

Wang,

Song,

Johnson

et al. 2023

Macromolecular Bioscience

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Wound infections slow down the healing process and lead to complications such as septicemia, osteomyelitis, and even death. Although traditional methods relying on antibiotics are effective in controlling infection, they have led to the emergence of antibiotic‐resistant bacteria. Hydrogels with antimicrobial function become a viable option for reducing bacterial colonization and infection while also accelerating healing processes. Chitosan is extensively developed as antibacterial wound dressings due to its unique biochemical properties and inherent antibacterial activity. In this review, the recent research progress of chitosan‐based hydrogels for infected wound treatment, including the fabrication methods, antibacterial mechanisms, antibacterial performance, wound healing efficacy, etc., is summarized. A concise assessment of current limitations and future trends is presented.

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N,N,N-trimethyl chitosan as an efficient antibacterial agent for polypropylene and polylactide nonwovens

Cited by 14 publications

References 19 publications

Smart Design of Rapid Crystallizing and Nonleaching Antibacterial Poly(lactide) Nanocomposites by Sustainable Aminolysis Grafting and in Situ Interfacial Stereocomplexation

Smart Design of Rapid Crystallizing and Nonleaching Antibacterial Poly(lactide) Nanocomposites by Sustainable Aminolysis Grafting and in Situ Interfacial Stereocomplexation

The Effect of Molecular Weight on the Antibacterial Activity of N,N,N-Trimethyl Chitosan (TMC)

Chitosan‐Based Hydrogels for Infected Wound Treatment

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