N-Rich, Polyphenolic Porous Organic Polymer and Its In Vitro Anticancer Activity on Colorectal Cancer

Abstract

N-rich organic materials bearing polyphenolic moieties in their building networks and nanoscale porosities are very demanding in the context of designing efficient biomaterials or drug carriers for the cancer treatment. Here, we report the synthesis of a new triazine-based secondary-amine- and imine-linked polyphenolic porous organic polymer material TrzTFPPOP and explored its potential for in vitro anticancer activity on the human colorectal carcinoma (HCT 116) cell line. This functionalized (-OH, -NH-, -C=N-) organic material displayed an exceptionally high BET surface area of 2140 m2 g−1 along with hierarchical porosity (micropores and mesopores), and it induced apoptotic changes leading to high efficiency in colon cancer cell destruction via p53-regulated DNA damage pathway. The IC30, IC50, and IC70 values obtained from the MTT assay are 1.24, 3.25, and 5.25 μg/mL, respectively.

Conformational switch of a peptide provides a novel strategy to design peptide loaded porous organic polymer for Pyroptosis pathway mediated cancer therapy

“…We then loaded synthesized PEP1 onto a newly synthesized porous organic polymers (POPs) (PG-DFC-PEG-PEP1) to investigate if it can target cancer cells selectively using a Colorectal Cancer Cell (CRC)line. Organic materials bearing multiple phenolic-OH sites in the polymer network have shown high therapeutic activity as carrier or drug for cancer treatments 15,16 . In this context, porous organic polymers are an interesting class of materials bearing nanoscale porosity and they are synthesized through copolymerization of reactive organic building blocks.…”

Fabrication and properties of Sn(iv) porphyrin-linked porous organic polymer for environmental applications

“…The multidimensional properties of these materials make them good alternatives to classical porous materials, such as zeolites, 5 metal oxides, 6 ceramics, 7 mesoporous silica, 8 and activated charcoal. 9 These materials have been extensively studied and utilized in various fields including heterogeneous catalysis, 10 gas storage, 11 biomedicine, 12 gas separation, 13 water purification, 14 electrochemistry, 15 and sensing. 16 POPs, which are highly cross-linked amorphous porous materials, are typically characterized by ample molecular-scale porosity (pore diameters ranging from a few nanometers to micrometers).…”