N staging: the role of the pathologist

Marco, C; Biondi, Alberto; Ricci, Riccardo

doi:10.21037/tgh.2017.01.02

Cited by 12 publications

(8 citation statements)

References 64 publications

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“…The average number of lymph nodes harvested in the PSI group was significantly superior to that in the PS group in the prospective study, while the number harvested in the PS group was significantly higher than in the EBS group in the retrospective study. Some researchers pointed out that at least 25 lymph nodes should be harvested in patients with advanced gastric cancer 33,34. Accordingly, we demonstrated a significant difference in the proportions of patients in whom least 25 lymph nodes were harvested among these three groups.…”

Section: Discussionsupporting

confidence: 46%

<p>Lymph Node Yield Following Packet Submission After Isolation By Surgeon During Gastrectomy</p>

Wang

Zhang

et al. 2019

CMAR

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PurposeTo compare the lymph node yields of lymph node packet submission (PS), packet submission after isolation by surgeons (PSI), and en bloc lymph node submission (EBS) after gastrectomy.MethodsWe conducted a prospective study including 118 gastric cancer patients who underwent gastrectomy between June 2016 and August 2016. We also retrospectively reviewed 607 patients who underwent gastrectomy from May 2015 to May 2016. Following gastrectomy, lymph node specimens were either submitted en bloc (EBS group), divided into packets with accompanying adipose tissue according to the lymph node stations (PS group), or isolated individually based on the surgeon’s visualization and palpation before submission to the Pathology Department (PSI group).ResultsThe average lymph node yield was significantly higher in the PSI compared with the PS group in the prospective study (46.5±19.4 vs 31.8±11.1), and significantly higher in the PS compared with the EBS group in the retrospective study (31.5±12.6 vs 23.9±8.9) (both P<0.001). There was no significant difference in positive lymph node yields in either of these comparisons (prospective study, P=0.581; retrospective study, P=0.489). The survival curve indicated no significant difference between the PS and PSI groups (log rank P=0.957); however, these three groups share different lymph node ratio (LNR).ConclusionPSI could yield more lymph nodes than PS or EBS with a lower LNR at pathological examination. However, the difference in lymph nodes harvested had no impact on survival, which may need further investigation.

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Section: Discussionsupporting

confidence: 46%

<p>Lymph Node Yield Following Packet Submission After Isolation By Surgeon During Gastrectomy</p>

Wang

Zhang

et al. 2019

CMAR

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“…There is apparent discordance in the diagnostic level of clinical and pathological staging and classification accuracy, making it difficult to provide high quality evidence to support the postoperative treatment of gastric cancer [10]. Based on relevant studies and clinical practice, we focused on the importance and effectiveness of correctly evaluating TNM staging, highlighting critical issues with the purpose of investigating factors influencing evaluation of infiltration, lymph node retrieval and analysis, with particular emphasis on the roles of the surgeon and pathologist in processing surgical specimens.…”

Section: Introductionmentioning

confidence: 99%

Clinical and pathological staging of gastric cancer: Current perspectives and implications

Zhu

Gong

2020

European Journal of Surgical Oncology

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“…As the study is only authored by surgeons without any pathologist as a co-author this potential bias might be difficult to control. So even if surgical quality of lymphadenectomy did not differ, various quality of pathological examination has to be controlled as detection of lymph node metastasis is challenging and can vary among different techniques (12).…”

mentioning

confidence: 99%