N-stearoyltyrosine protects primary cortical neurons against Aβ(1–40)-induced injury through inhibiting endocannabinoid degradation

Cui, Hengjing; Yang, Rui; Li, Sha; Fu, Guo‐Hui; Yang, Lu

doi:10.1016/j.lfs.2015.01.012

Cited by 6 publications

(2 citation statements)

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“…3 They function as pleiotropic bioactive lipids for nociception, 4 bone function, 5,6 metabolism, 7,8 and neurodegeneration. 9 Recently, several novel amino acid-conjugated bile acids were reported to agonize the farnesoid X receptor. 10 These sterol amino acids (STAs) are structurally analogous to NAAs.…”

Section: ■ Introductionmentioning

confidence: 99%

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Discovery of N-Acyl Amino Acids and Novel Related N-, O-Acyl Lipids by Integrating Molecular Networking and an Extended In Silico Spectral Library

Yuan

et al. 2023

Anal. Chem.

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Research on novel bioactive lipids has garnered increasing interest. Although lipids can be identified by searching mass spectral libraries, the discovery of novel lipids remains challenging as the query spectra of such lipids are not included in libraries. In this study, we propose a strategy to discover novel carboxylic acid-containing acyl lipids by integrating molecular networking with an extended in silico spectral library. Derivatization was performed to improve the response of this method. The tandem mass spectrometry spectra enriched by derivatization facilitated the formation of molecular networking and 244 nodes were annotated. We constructed consensus spectra for these annotations based on molecular networking and developed an extended in silico spectral library based on these consensus spectra. The spectral library included 6879 in silico molecules covering 12,179 spectra. Using this integration strategy, 653 acyl lipids were discovered. Among these, O-acyl lactic acids and N-lactoyl amino acid-conjugated lipids were annotated as novel acyl lipids. Compared with conventional methods, our proposed method allows for the discovery of novel acyl lipids, and extended in silico libraries significantly increase the size of the spectral library.

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Section: ■ Introductionmentioning

confidence: 99%

“…NAAs are present in tissue , and blood of mammalian . They function as pleiotropic bioactive lipids for nociception, bone function, , metabolism, , and neurodegeneration . Recently, several novel amino acid-conjugated bile acids were reported to agonize the farnesoid X receptor .…”

Section: Introductionmentioning

confidence: 99%