Risperidone ameliorated Aβ1-42-induced cognitive and hippocampal synaptic impairments in mice

Wu, Lingzhi; Feng, Xiaowen; Li, Tingting; Sun, Bo; Khan, Muhammad Zahid; He, Ling

doi:10.1016/j.bbr.2017.01.020

Cited by 25 publications

(14 citation statements)

References 51 publications

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“…These results return to control group levels with citalopram and combined treatments. Consistent with our results recent experimental studies have also shown that risperidone are ameliorated cognitive dysfunction in hippocampus [45,47].…”

Section: Discussionsupporting

confidence: 93%

The effects of citalopram and low-dose risperidone on memory and anxiety in rats subjected to chronic immobilization stress

Aykaç

Şehirli

2018

Psychiatry and Clinical Psychopharmacology

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OBJECTIVES: Many clinical reports describe the beneficial effects of low-dose atypical antipsychotic added to the antidepressants in the management of anxiety disorders. The aim of this study was to evaluate the effect of low-dose atypical antipsychotic when added to antidepressant treatment on cholinergic M 1 receptor expression in the hippocampus and amygdale region in learning and cognitive disorders caused by anxiety. METHODS: The treatments were administered by using different test models on memory, learning, and anxiety, as well as the effect on muscarinic M 1 receptor expression levels were assessed. Citalopram (10 mg/kg/sc) and combination [citalopram and risperidone (1 mg/kg/ sc)] treatments were applied after stress induction using the immobilization model in rats. Animals groups were randomly divided as: control, stress, stress + citalopram, and stress + combination treatment group. Rats in stress groups were immobilized in cages for 4 h a day for 15 days. On days 1-5, groups were subjected to Morris water maze (MWM), open field, and elevated plus maze (EPM) tests. RESULTS: MWM test results have shown that citalopram induces an anxiolytic effect. Low-dose risperidone treatment has increased the antidepressant-like activity of citalopram in all tests. In OFT the number of squares that rats were circulating on the plane was increased and the time spent by the rats on the maze platform was also increased in MWM. In addition to this, the time spent by the rats on the open arms of the EPM test were also increased. Since the combined treatment increased the discovery of the environment and the active behaviour in tests; all those reflected the increase in general activity. Findings also suggest that treatments may play an effective role in altering the expression level of M 1 receptors which are effective in learning and recalling information in the amygdale and the hippocampus. Combination treatment has been shown to provide a meaningful correction of stress-induced memory and learning functions. CONCLUSIONS: These findings indicate that combination treatment may help reduce the stress-induced impairments in cognitive functions. ARTICLE HISTORY

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Section: Discussionsupporting

confidence: 93%

The effects of citalopram and low-dose risperidone on memory and anxiety in rats subjected to chronic immobilization stress

Aykaç

Şehirli

2018

Psychiatry and Clinical Psychopharmacology

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“…Step‐down was performed as previously described; on the first day of training, mice were conducted to learning for 5 min. If the animals slipped down from the platform, they were accepted an electric foot shock (36 V, AC).…”

Section: Methodsmentioning

confidence: 99%

Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model

Gong

Hua

Zang

et al. 2018

Journal of Pharmacy and Pharmacology

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Objectives The objective of this study was to evaluate whether melatonin could ameliorate cognitive function in Ab 1-42 -induced mouse model and its underlying mechanisms. Methods Series behaviour tests were performed to demonstrate the amelioration of cognitive function of the Alzheimer's disease (AD) mice induced by Ab 1-42 . Additionally, enzyme-linked immunosorbent assay was applied to detect the expression of Ab 1-42 , BACE1 and p-tau protein in the brain of the AD mice. JC-1 was performed to investigate the role in alleviating mitochondrial damage by melatonin in vitro. Western blot was used to detect the expression of melatonin on apoptosis-related factors caspase-3 and Bcl-2, as well as the expressions of GSK-3b and PP2A to further determine the mechanisms of melatonin on the expression of p-tau protein.Key findings Melatonin significantly ameliorated the cognitive function and mitochondrial damage in AD mice, reduced the expression levels of GSK-3b, caspase-3, Ab 1-42 , BACE1, p-tau protein and increased the expressions of PP2A and Bcl-2. Conclusion From the overall results, we concluded that melatonin alleviated the mitochondrial damage effectively and decreased the expressions of the p-tau and some key proteins of apoptosis, leading to the improvement of cognitive function of the mice induced by Ab 1-42 .

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“…Memory and cognitive de cits are the most primary clinical manifestation in patients with AD, are implicated with the deposition of Aβ plaques in the hippocampal area and CAA in the brain (Rosa & Fahnestock, 2014). Previous studies have shown that spatial learning impairment and memory de cits were developed after Aβ microinjection in the hippocampus of rodent models (Sharma, Verma, Kapoor, Saini, & Nehru, 2016; Wu et al, 2017). Our data aligned with the previous nding that the escape latency and traveled distance were signi cantly increased in AD group compared to CON group in the acquisition phase (Fig.…”

Section: Discussionmentioning

confidence: 99%

Exercise training ameliorates cognitive dysfunction in amyloid beta-injected rat model: possible mechanisms of Angiostatin/VEGF signaling

et al. 2021

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Vascular endothelial growth factor (VEGF) regulates angio/neurogenesis and also tightly links to the pathogenesis of Alzheimer's disease (AD). Although exercise has a bene cial effect on neurovascular function and cognitive function, the direct effect of exercise on VEGF-related signaling and cognitive de cit in AD are incompletely understood. Therefore, the purpose of this study was to investigate the protective effect of exercise on angiostatin/VEGF cascade and cognitive function in AD model rats. Wistar male rats were randomly divided into ve groups: control (CON), injection of DMSO (Sham-CON), CON-exercise (sham-EX), intrahippocampal injection of Aβ (AD), and AD-exercise (AD-EX). Rats in EX groups underwent treadmill exercise for 4 weeks, then the cognitive function was measured by the Morris Water Maze (MWM) test. mRNA levels of HIF-1, VEGF, VEGFR2, and angiostatin were determined by RT-PCR. We found that cognitive function was impaired in AD rats, but exercise training improved it.Moreover, exercise training increased the reduced mRNA expression level of VEGF signaling, including HIF1α, VEGF, and VEGFR2 in the hippocampus from AD rats. Also, the mRNA expression level of angiostatin was elevated in the hippocampus from AD rats, and exercise training abrogated its expression. Our ndings suggest that exercise training improves cognitive function in AD, possibly through enhancing VEGF signaling and reducing angiostatin.

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Risperidone ameliorated Aβ1-42-induced cognitive and hippocampal synaptic impairments in mice

Cited by 25 publications

References 51 publications

The effects of citalopram and low-dose risperidone on memory and anxiety in rats subjected to chronic immobilization stress

The effects of citalopram and low-dose risperidone on memory and anxiety in rats subjected to chronic immobilization stress

Melatonin ameliorates Aβ1-42-induced Alzheimer's cognitive deficits in mouse model

Exercise training ameliorates cognitive dysfunction in amyloid beta-injected rat model: possible mechanisms of Angiostatin/VEGF signaling

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