Na7CrCuW11O39.16H2O induces apoptosis in human ovarian cancer SKOV3 cells through the p38 signaling pathway

Polyoxometallate (POMs) haben großes Potenzial, verschiedene Tumorarten zu inhibieren; ihre Toxizität und unspezifischen Wechselwirkungen mit Biomolekülen verhindern jedoch eine klinische Anwendung. Der Schwerpunkt bei biologisch aktiven POMs liegt gegenwärtig auf organisch funktionalisierten POMs und POM‐basierten Nanokomposit‐Strukturen, da diese Hybride eine erhöhte Aktivität gegen Tumoren aufweisen, bei einer gleichzeitig deutlich verringerten Toxizität gegen normale Zellen. Während die Antitumoraktivität von POMs ausreichend beschrieben ist, sind ihre Wirkungsmechanismen noch weitgehend unbekannt. Dieser Aufsatz gibt einen Überblick über die zytotoxischen Effekte von POMs, wobei der Schwerpunkt auf POM‐basierten Hybriden und Nanokomposit‐Strukturen liegen soll. Postulierte Wirkungsmechanismen werden vorgestellt und molekulare Targets identifiziert. POMs könnten sich zur nächsten Generation metallhaltiger Krebsmedikamente entwickeln, die selektiv nur Krebszellen angreifen und gesunde Zellen verschonen.

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Im Kampf gegen Krebs: Polyoxometallate als nächste Generation metallhaltiger Medikamente

Bijelic

Aureliano

Rompel

2018

Angewandte Chemie

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Inhibition of Mitochondrial ATP Synthesis and Regulation of Oxidative Stress Based on {SbW₈O₃₀} Determined by Single‐Cell Proteomics Analysis

et al. 2021

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The 10-nuclear heteroatom cluster modified {SbW 8 O 30 }w as successfully synthesized and exhibited inhibitory activity (IC 50 = 0.29 mM). Based on proteomics analysis, Na 4 Ni 2 Sb 2 W 2-SbW 8 inhibited ATPproduction by affecting the expression of 16 related proteins,h indering metabolic functions in vivo and cell proliferation due to reactive oxygen species (ROS) stress.Inparticular,the lowexpression of FAD/ FMN-binding redox enzymes (relative expression ratio of the experimental group to the control = 0.43843) could be attributed to the redoxmechanism of Na 4 Ni 2 Sb 2 W 2-SbW 8 ,which was consistent with the effect of polyoxometalates (POMs) and FMN-binding proteins on ATPformation. An electrochemical study showed that Na 4 Ni 2 Sb 2 W 2-SbW 8 combined with FMN to form Na 4 Ni 2 Sb 2 W 2-SbW 8-2FMN complex through ao ne-electron process of the Wa toms.N a 4 Ni 2 Sb 2 W 2-SbW 8 acted as catalase and glutathione peroxidase to protect the cell from ROSstress,and the inhibition rates were 63.3 %at1.77 mMof NADPH and 86.06 %a t1 0.62 mMo f2-hydroxyterephthalic acid. Overall, our results showed that POMs can be specific oxidative/antioxidant regulatory agents.

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{BiW₈O₃₀} Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species

et al. 2021

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We successfully synthesized {BiW 8 },a10-nuclear heteroatom cluster modified {BiW 8 O 30 }. At 24 hp ost-incubation, the IC 50 values of {BiW 8 } against HUVEC,M G63, RD, Hep3B,H epG2, and MCF7 cells were 895.8, 127.3, 344.3, 455.0, 781.3, and 206.3 mM, respectively.T he IC 50 value of {BiW 8 } on the MG63 cells was more than 2-fold lower than that of the other raw materials.T hrough morphological and functional features,w ed emonstrated pyroptosis as an ewly identified mechanism of cell death induced by {BiW 8 }. {BiW 8 } increased 2-fold reactive oxygen species (ROS)levels in MG63 cells at 24 hp ost-incubation. Compared with 0h,t he glutathione (GSH) content decreased by 59, 65, 75, 94, and 97 %at 6, 12, 24, 36 and 48 hp ost-incubation, respectively.F urthermore,m ultiple antitumor mechanisms of {BiW 8 } were identified via transcriptome analysis and chemical simulation, including activation of pyroptosis,s uppression of GSH generation, depletion of GSH, and inhibition of DNAr epair.

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Na7CrCuW11O39.16H2O induces apoptosis in human ovarian cancer SKOV3 cells through the p38 signaling pathway

Cited by 8 publications

References 35 publications

Im Kampf gegen Krebs: Polyoxometallate als nächste Generation metallhaltiger Medikamente

Im Kampf gegen Krebs: Polyoxometallate als nächste Generation metallhaltiger Medikamente

Inhibition of Mitochondrial ATP Synthesis and Regulation of Oxidative Stress Based on {SbW₈O₃₀} Determined by Single‐Cell Proteomics Analysis

{BiW₈O₃₀} Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species

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Na7CrCuW11O39.16H2O induces apoptosis in human ovarian cancer SKOV3 cells through the p38 signaling pathway

Cited by 8 publications

References 35 publications

Im Kampf gegen Krebs: Polyoxometallate als nächste Generation metallhaltiger Medikamente

Im Kampf gegen Krebs: Polyoxometallate als nächste Generation metallhaltiger Medikamente

Inhibition of Mitochondrial ATP Synthesis and Regulation of Oxidative Stress Based on {SbW8O30} Determined by Single‐Cell Proteomics Analysis

{BiW8O30} Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species

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Product

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Inhibition of Mitochondrial ATP Synthesis and Regulation of Oxidative Stress Based on {SbW₈O₃₀} Determined by Single‐Cell Proteomics Analysis

{BiW₈O₃₀} Exerts Antitumor Effect by Triggering Pyroptosis and Upregulating Reactive Oxygen Species