NACH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modifies the Effects of Alcohol Consumption on Risk for Hypertension in Middle-Aged Japanese Men

Kokaze, Akatsuki; Ishikawa, Mamoru; Matsunaga, Naomi; Yoshida, Masao; Satoh, Masao; Teruya, Koji; Masuda, Yumi; Honmyo, Rie; Uchida, Yoshiko; Takashima, Yutaka

doi:10.1291/hypres.30.213

Cited by 22 publications

(44 citation statements)

References 29 publications

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“…[7][8][9] The frequency of the Mt5178A genotype is significantly higher in Japanese centenarians than in the general population. 7 Compared with those with Mt5178A, Japanese individuals with Mt5178C are more susceptible to lifestylerelated adult-onset diseases, such as hypertension, 10 diabetes, 11 myocardial infarction 12,13 and cerebrovascular disorders. 14 This polymorphism is reportedly associated with serum lipid levels 15 and fasting plasma glucose levels.…”

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confidence: 99%

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

et al. 2010

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The objective of this study was to investigate whether the mitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism modifies the effects of coffee consumption on serum lipid levels and the risk of dyslipidemia in middle-aged Japanese men. A total of 397 male subjects (age, 53.9±7.8 years; mean±s.d.) were selected from among individuals visiting the hospital for regular medical check-ups. After adjustment for age, body mass index, habitual alcohol consumption, habitual smoking and use of antihypertensive medication, among subjects who consumed o1 cup of coffee per day, the odds ratio (OR) for hyper-low-density lipoprotein (LDL) cholesterolemia (serum LDL cholesterol X140 mg per 100 ml) was significantly lower in those with Mt5178A than in those with Mt5178C (OR¼0.378, 95% confidence interval: 0.153-0.919). After adjustment, the association between the Mt5178A genotype and hyper-LDL cholesterolemia depended on coffee consumption (P for trend¼0.018). Coffee consumption was positively associated with serum LDL cholesterol levels only in subjects with Mt5178A. However, in subjects with Mt5178C, serum LDL cholesterol level or risk of hyper-LDL cholesterolemia did not seem to depend on coffee consumption. These results suggest that for men with Mt5178A, coffee consumption negates the genetic benefit of lower risk for hyper-LDL cholesterolemia.

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Section: Introductionmentioning

confidence: 99%

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

et al. 2010

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“…The frequency of the Mt5178A genotype, a genetic marker of mitochondrial haplogroup D, is significantly higher in Japanese centenarians than in the general population (Alexe et al 2007;Tanaka et al 1998) and it is reported that individuals with Mt5178A (mitochondrial haplogroup D) are less susceptible to lifestyle-related adult-onset diseases, for example hypertension (Kokaze et al 2007), diabetes (Wang et al 2001), metabolic syndrome ), myocardial infarction (Mukae et al 2003;Takagi et al 2004), and cerebrovascular diseases (Ohkubo et al 2002), than those with Mt5178C. Mt5178 C/A polymorphism is, moreover, also reported to be associated with blood pressure (Kokaze et al 2004a(Kokaze et al , 2007, serum lipid levels (Kokaze et al 2001(Kokaze et al , 2003a, fasting plasma glucose levels and glucose tolerance (Kokaze et al 2005a), serum uric acid levels (Kokaze et al 2006), intraocular pressure (Kokaze et al 2004b), hematological data (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2002(Kokaze et al , 2003b, and its interaction with smoking habits is associated with serum triglyceride levels (Kokaze et al 2003a), intraocular pressure (Kokaze et al 2004b), red blood cell counts (Kokaze et al 2005b), and serum protein fraction levels (Kokaze et al 2003b). As far as we are aware, however, no information is available about the relationship between Mt5178 C/A polymorphism and respiratory function or about its interaction with smoking habits in respiratory function.…”

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confidence: 99%

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

et al. 2007

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Pulmonary function is a crucial factor associated with longevity. Mitochondrial DNA 5178 cytosine/ adenine (Mt5178 C/A) polymorphism is reported to be associated with longevity in the Japanese population. We have previously reported that Mt5178 C/A polymorphism is widely associated with physiological and biochemical status. The objective of this study was to investigate whether Mt5178 C/A polymorphism is associated with pulmonary function. The subjects were 463 Japanese men (mean age ± SD 54.0 ± 7.6 years). Genotyping of Mt5178 C/A was performed by polymerase chain reaction-restriction fragment length polymorphism. A cross-sectional study of the relationship between genotype and spirometric data, namely forced vital capacity (FVC) and forced expiratory volume in 1 s (FEV 1 ), was conducted. Among younger subjects (age <55 years), FVC and FEV 1 were significantly higher for men with Mt5178A than for those with Mt5178C. Interaction between Mt5178 C/A polymorphism and smoking habits in FEV 1 /FVC ratio was observed. Cigarette consumption (pack-years of smoking) was significantly and negatively associated with FEV 1 / FVC ratio for men with Mt5178C. Among older subjects (age ‡55 years), FEV 1 /FVC ratio was significantly lower for current smokers with Mt5178C than for never smokers with Mt5178C or for never smokers with Mt5178A. Mt5178 C/A polymorphism and its interaction with cigarette consumption may be associated with pulmonary function in Japanese men.

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“…The frequency of the Mt5178A genotype is significantly higher in Japanese centenarians than in the general population [5]. Japanese individuals with Mt5178A are more resistant to hypertension [6], diabetes [7], myocardial infarction [8, 9] and cerebrovascular disorders [10] than those with Mt5178C. Moreover, Mt5178 C/A polymorphism interacts with several lifestyle habits, namely habitual smoking [11–14], alcohol consumption [6, 14, 15], coffee consumption [16–18] and green tea consumption [19], on the risk of lifestyle-related diseases.…”

Section: Introductionmentioning

confidence: 99%

“…Japanese individuals with Mt5178A are more resistant to hypertension [6], diabetes [7], myocardial infarction [8, 9] and cerebrovascular disorders [10] than those with Mt5178C. Moreover, Mt5178 C/A polymorphism interacts with several lifestyle habits, namely habitual smoking [11–14], alcohol consumption [6, 14, 15], coffee consumption [16–18] and green tea consumption [19], on the risk of lifestyle-related diseases. Mt5178 C/A polymorphism influences the effects of coffee consumption on the risk of hypertension [16], hyper-low-density lipoprotein (LDL) cholesterolemia [17] and the clustering of cardiovascular risk factors [18].…”

Section: Introductionmentioning

confidence: 99%

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis

Kokaze

Ishikawa

Matsunaga

et al. 2014

J Physiol Anthropol

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BackgroundMitochondrial DNA 5178 cytosine/adenine (Mt5178 C/A) polymorphism reportedly modulates the effects of coffee consumption on the risk of hypertension, dyslipidemia and abnormal glucose tolerance. The objective of this analysis was to investigate whether Mt5178 C/A polymorphism modifies the effects of coffee consumption on erythrocytic parameters in male Japanese health check-up examinees.MethodsA total of 436 men (mean age ± standard deviation, 54.1 ± 7.8 years) were selected from among individuals visiting the hospital for regular medical check-ups. After Mt5178 C/A genotyping, an exploratory cross-sectional analysis assessing the joint effects of Mt5178 C/A polymorphism and coffee consumption on red blood cell counts, hematocrit and hemoglobin was conducted.ResultsFor Mt5178C genotypic men, after adjustment for age, body mass index, alcohol consumption, habitual smoking and green tea consumption, coffee consumption significantly decreased red blood cell counts (P for trend = 0.022) and hemoglobin (P for trend = 0.035). The risk of anemia, defined as hemoglobin of <14 g/dL, after the aforementioned adjustment, appeared to depend on coffee consumption (P for trend = 0.078), and the adjusted odds ratio for anemia was significantly higher in men who consumed ≥4 cups of coffee per day than in those who consumed <1 cup per day (odds ratio = 3.771, 95% confidence interval: 1.088 to 13.06, P = 0.036). For Mt5178A genotypic men, coffee consumption possibly reduced the risk of anemia (P for trend = 0.049). However, after the aforementioned adjustment, the statistical significance disappeared (P for trend = 0.137).ConclusionsThis exploratory cross-sectional analysis suggests that Mt5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters and the risk of anemia in male Japanese health check-up examinees.

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NACH Dehydrogenase Subunit-2 237 Leu/Met Polymorphism Modifies the Effects of Alcohol Consumption on Risk for Hypertension in Middle-Aged Japanese Men

Cited by 22 publications

References 29 publications

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Combined effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and coffee consumption on the risk of hyper-LDL cholesterolemia in middle-aged Japanese men

Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis

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