NAD(P)H:quinone oxidoreductase 1 (NQO1): chemoprotection, bioactivation, gene regulation and genetic polymorphisms

Ross, David; Kepa, Jadwiga K.; Winski, Shannon L.; Beall, Howard D.; Anwar, Adil; Siegel, David

doi:10.1016/s0009-2797(00)00199-x

Cited by 560 publications

(486 citation statements)

References 113 publications

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“…17,18 NQO1 catalyzes the two electron reduction of electrophilic quinone compounds, thus limiting the formation of semiquinone radicals through one electron reduction, and the subsequent generation of ROS. 18,19 NQO1 is also able to maintain the cellular levels of ubiquinol and vitamin E, two important biological antioxidants involved in the detoxification of ROS. 17,20 Therefore, the coordinated actions of a spectrum of cellular antioxidants and probably other cytoprotective proteins ensure efficient detoxification of ROS and electrophilic species that participate in the pathogenesis of SCI.…”

Section: Ros and Oxidative Stress In Scimentioning

confidence: 99%

Oxidative stress in spinal cord injury and antioxidant-based intervention

Jia

Zhu

Li³

et al. 2011

Spinal Cord

265

176

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Study design: Literature review. Objectives: Spinal cord injury (SCI) remains a major public health issue in developed countries as well as worldwide. The pathophysiology of SCI is characterized by an initial primary injury followed by secondary deterioration. Although the etiology and pathogenesis of SCI remain to be fully understood, it has been suggested that reactive oxygen species (ROS) and oxidative stress have a significant role in the pathophysiology of SCI. Thus, alleviating oxidative stress may be an effective strategy for therapeutic intervention of SCI. The aim of this review was to describe (i) the sources of ROS as well as the major antioxidant defenses with particular attention being paid to lipid peroxidation; (ii) the biomarkers of oxidative stress in SCI and (iii) the neuroprotective effects of various compounds with antioxidative properties in animal models of SCI. Methods: PubMed, one of the most comprehensive biomedical databases, was searched from 1976-2011. All relevant papers were read by title, abstract and full-length article. Results: Oxidative stress is considered a hallmark of injury of SCI. Thus, alleviating oxidative stress may be an effective way of therapeutic intervention of SCI. Two of these agents, the glucocorticoid steroid methylprednisolone and the non-glucocorticoid 21-aminosteroid tirilazad, have been shown to possess significant antioxidant activities and improve recovery of SCI patients in clinical trials. Other promising botanical compounds and their molecular targets and mechanisms of action with regard to potential protection against SCI were also described. These include carotenoids and phenolic compounds. Conclusion: ROS and oxidative stress have a significant role in the pathophysiology of SCI. Alleviating oxidative stress is be an effective strategy for therapeutic intervention of SCI. Extensive research over the past several decades has identified numerous bioactive compounds that have antioxidative stress benefits in animal models of SCI. Thus, continued studies on bioactive compounds with ROS-scavenging capacity may lead to the development of effective antioxidant-based modalities for treating SCI in human subjects.

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Section: Ros and Oxidative Stress In Scimentioning

confidence: 99%

Oxidative stress in spinal cord injury and antioxidant-based intervention

Jia

Zhu

Li³

et al. 2011

Spinal Cord

265

176

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“…When MS cases were stratified by disease course the T allele was overrepresented in PPMS patients versus bout onset MS patients (OR ¼ 2.98, p ¼ 0.009). This functional allele affects individual vulnerability to oxidative damage (Dinkova-Kostova and Talalay, 2000;Ross et al, 2000) and as such may influence MS risk. This allele is implicated in other degenerative diseases, including Alzheimer's disease (Bian et al, 2008) and Parkinson's disease (Shao et al, 2001).…”

Section: Nad(p)h: Quinone Reductase 1 (Nqo1)mentioning

confidence: 99%

Genetics of primary progressive multiple sclerosis

Cree

2014

Handbook of Clinical Neurology

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“…Nicotinamide adenine dinucleotide phosphate: quinone oxidoreductase 1 (NQO1) plays an important role in the body's defense system against oxidative stress [2]. NQO1 detoxifies quinines and their derivatives and prevents their participation in redox cycling, therefore reducing oxidative stress [3].…”

Section: Introductionmentioning

confidence: 99%

“…A homozygous mutation results in a complete loss of NQO1 protein and enzymatic activity. Therefore, a mutation at this locus could increase susceptibility to oxidative stress [2,8]. This NQO1 polymorphism has been reported to have an additive effect on oxidative damage, thus manifesting a biological significance for cancer susceptibility and chemoprotection [3,8].…”

Section: Introductionmentioning

confidence: 99%