2012
DOI: 10.1016/j.freeradbiomed.2012.08.584
|View full text |Cite|
|
Sign up to set email alerts
|

NAD(P)H:quinone oxidoreductase 1 protects bladder epithelium against painful bladder syndrome in mice

Abstract: Painful Bladder Syndrome (PBS) or interstitial cystitis (IC) is a poorly understood chronic disease, which is characterized by thinning of bladder epithelium and intense pain. Here we demonstrate that NAD(P)H:quinone oxidoreductase 1−/− (NQO1−/−) mice developed in our laboratory represent a new animal model of PBS. NQO1 is known to protect against physiological stress as well as transcription factors against proteasomal degradation. In the present study we demonstrate that NQO1 is necessary for bladder epithel… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

1
8
0

Year Published

2013
2013
2021
2021

Publication Types

Select...
7

Relationship

2
5

Authors

Journals

citations
Cited by 10 publications
(9 citation statements)
references
References 30 publications
1
8
0
Order By: Relevance
“…Indeed, NQO1 knockout diabetic mice had increased hyperglycemia and higher ROS expression, revealing the important neuroprotective role played by this enzyme during diabetes [38, 39]. As expected, we demonstrated a reduced expression of this enzyme in the sciatic nerve of db/db mice as occurs in type 1 diabetic animals [28].…”
Section: Discussionsupporting
confidence: 69%
“…Indeed, NQO1 knockout diabetic mice had increased hyperglycemia and higher ROS expression, revealing the important neuroprotective role played by this enzyme during diabetes [38, 39]. As expected, we demonstrated a reduced expression of this enzyme in the sciatic nerve of db/db mice as occurs in type 1 diabetic animals [28].…”
Section: Discussionsupporting
confidence: 69%
“…Regenerated wound tissues on postsurgery day 7 were excised from various groups and fixed in paraformaldehyde.Then, 10-µm sections were stained with hematoxylin and eosin and Masson's Trichrome (Sigma) to evaluate the cellular proliferation and collagen deposition, respectively, as described earlier [19]. The images of stained sections were taken using a microscope (Olympus) at 10 × magnification.…”
Section: Histopathologic Analysismentioning
confidence: 99%
“…Furthermore, another important antioxidant enzyme activated by the transcription factor Nrf2 is the NAD(P)H quinone oxidoreductase 1 (NQO1). The up-regulation of this enzyme modulates oxidative stress and abundant neuro-inflammatory responses also accountable for diabetic neuropathy induction [ 12 , 13 ]. Nevertheless, the effects of CoPP (an HO-1 inducer compound) on the expression of this enzyme in type 2 diabetic animals have not been assessed.…”
Section: Introductionmentioning
confidence: 99%