Nadifloxacin downmodulates antigen-presenting functions of epidermal Langerhans cells and keratinocytes

Murata, Kōji; Sugita, Kazunari; Miwa, Koichi; Kabashima, Kenji; Tokura, Y.

doi:10.1016/j.jdermsci.2005.12.008

Cited by 13 publications

(12 citation statements)

References 26 publications

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“…Furthermore, accumulating evidence has shown that NDFX has downmodulatory actions on immunocompetent cells. NDFX inhibits migration of neutrophils 20 and has immunomodulatory bioactivities on keratinocytes, peripheral mononuclear cells 21 and Langerhans cells 22 . Especially, NDFX inhibits production of cytokines interleukin (IL)‐1, IL‐6, IL‐8 and γ‐interferon related with acne inflammation 21,23,24 .…”

Section: Discussionmentioning

confidence: 99%

Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study

Miwa

Nakagawa²,

Fukamachi³

et al. 2011

The Journal of Dermatology

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Topical retinoid and antibiotic combination therapy is an integral part of acne treatment and is considered the appropriate first-line therapy according to the Japanese guideline for moderate and severe acne. In this combination, clindamycin or doxycycline are mostly used as antibiotics, but there have been no reports on the effectiveness of nadifloxacin, a widely used antibiotic in Japan and European countries for acne, in combination with topical retinoid. To confirm the efficacy and safety of adapalene gel and nadifloxacin cream in the treatment of Japanese patients with acne vulgaris, a total of 50 patients were randomized to the two groups, the combination therapy and the adapalene monotherapy, and each therapy was tested for 8 weeks. The percentage reduction in the number of inflammatory acne lesions was evaluated and the safety was monitored through adverse events. The combination of adapalene gel and nadifloxacin cream produced a significantly higher reduction in the inflammatory lesions at 2 weeks (P = 0.047) and at 8 weeks (P = 0.011) after the starting than did adapalene gel monotherapy. The combination did not elevate the side effects of erythema and scale scores, but rather significantly depressed erythema at 1 week. This study showed the efficacy and safety of the combination therapy of nadifloxacin cream with adapalene gel for the inflammatory acne.

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Section: Discussionmentioning

confidence: 99%

Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study

Miwa

Nakagawa²,

Fukamachi³

et al. 2011

The Journal of Dermatology

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“…Like fluoroquinolones, which are also phototoxic molecules, voriconazole may amplify local, systemic immuno-suppression [19] and the genotoxicity [20] induced by UV. An amplification of immuno-suppression by local enhancement of the inhibitory effect on immuno-competent cells has been shown for fluoroquinolones [21]. Concerning genotoxicity, it has been reported, in an experimental model, that fluoroquinolones, especially lomefloxacin and fleroxacin, associated with UVA radiation, enhanced tumor prevalence and drastically shortened the median latent period of tumor onset compared with UVA alone [22–24].…”

Section: Discussionmentioning

confidence: 99%

Multifocal Aggressive Squamous Cell Carcinomas Induced by Prolonged Voriconazole Therapy: A Case Report

Morice

Acher

Soufir

et al. 2010

Case Reports in Medicine

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Voriconazole is a treatment for severe fungal infections. Prolonged voriconazole therapy may induce skin reactions, with 1% of severe photosensitivity accidents. Recently the imputability of voriconazole in skin carcinogenesis has been suggested. This report concerns a 55-year-old man suffering from pulmonary aspergillosis who presented a phototoxic reaction a few months after introduction of voriconazole, followed by multiple squamous cell carcinomas of sun-exposed skin areas. After voriconazole discontinuation, no new carcinoma was observed. The detection of EBV and HPV in skin lesions was negative. Exploration of gene mutations involved in skin carcinogenesis showed two variants of the MICR gene. The occurrence of multiple, recurrent, aggressive squamous cell carcinomas is rare with voriconazole, but its imputability is strongly suggested. A plausible hypothesis is that several factors including voriconazole uptake, immunosuppression, and genetic background could explain the phenotype of fast-developing skin carcinomas. Voriconazole therapy should be accompanied by stringent photoprotection and skin monitoring.

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“…Nadifloxacin is a synthetic bactericidal fluoroquinolone with a broad spectrum of antibacterial activity against aerobic Gram‐positive and Gram‐negative, as well as anaerobic bacteria, including P. acnes and Staphylococcus epidermidis 3,4 . It has been suggested to have not only antibacterial but also anti‐inflammatory actions, which may have a beneficial effect on some aspects of inflammatory acne 5,6 . Nadifloxacin 1% cream has been introduced into the market in Turkey recently.…”

Section: Introductionmentioning

confidence: 99%

Topical nadifloxacin 1% cream vs. topical erythromycin 4% gel in the treatment of mild to moderate acne

et al. 2010

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Topical antibiotics are the mainstay of therapy in mild to moderate inflammatory acne. Topical erythromycin is one of the most common prescribed topical antibiotics. Nadifloxacin, another topical antibiotic for acne, was recently introduced into the market in our country. In this study, we compared the efficacies and safety of topical nadifloxacin 1% cream and erythromycin 4% gel in acne. A total of 86 patients with mild to moderate facial acne were randomized into two treatment groups. The efficacies of the drugs were assessed by lesion counts. An acne severity index (ASI) was also calculated. In both groups, there was a significant reduction in lesion counts and ASI scores beginning from the first visit at week 4. This reduction continued throughout the 12-week study period. Both treatments were well tolerated. We conclude that when topically applied, both nadifloxacin 1% cream and erythromycin 4% gel are equally effective and safe treatments for mild to moderate facial acne.

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Nadifloxacin downmodulates antigen-presenting functions of epidermal Langerhans cells and keratinocytes

Cited by 13 publications

References 26 publications

Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study

Efficacy of combined topical treatment of acne vulgaris with adapalene and nadifloxacin: A randomized study

Multifocal Aggressive Squamous Cell Carcinomas Induced by Prolonged Voriconazole Therapy: A Case Report

Topical nadifloxacin 1% cream vs. topical erythromycin 4% gel in the treatment of mild to moderate acne

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