NADPH oxidases and ROS signaling in the gastrointestinal tract

Aviello, Gabriella; Knaus, Ulla G.

doi:10.1038/s41385-018-0021-8

Cited by 182 publications

(137 citation statements)

References 193 publications

Supporting

Mentioning

133

Contrasting

Unclassified

Order By: Relevance

“…According to some reports, doxorubicin also increases NADPH oxidase level and enzymes containing flavin like nitric oxide synthase, p450 reductase in cardiomyocytes. These enzymes increase the level of reactive oxygen species in the cell which leads to oxidative stress [31,32]. Doxorubicin has a strong affinity for Fe +3 ions and the reaction of ferric ions with hydroxyl and ketone groups of doxorubicin results in a free radical complex of doxorubicin-Fe +2 [33].…”

Section: Side Effectsmentioning

confidence: 99%

Molecular-Level Understanding of the Anticancer Action Mechanism of Anthracyclines

Shandilya¹,

Sharma²,

Das³

et al. 2021

Advances in Precision Medicine Oncology

View full text Add to dashboard Cite

Anthracyclines drugs are used as a treatment regime to combat cancer owing to their great chemotherapeutic potential. They are characterized by the presence of a wide range of derivatives, the most famous are doxorubicin and daunorubicin. The proposed action mechanism of anthracyclines and their derivatives to exert cytotoxic effect involves the intercalation of the drug molecule into nucleic acid and inhibition of the activity of topoisomerases. These events consequences in halting DNA replication and transcription mechanisms of the cell. Understanding of the structural and conformational changes associated with nucleic acid after binding with drugs provides significant knowledge for the development of more effective drugs. A comprehensive elucidation of the molecular mechanism(s) of action of anthracyclines drugs plays a significant role in the rational drug designing to obtain an effective, selective, and safe anti-cancer drugs.

show abstract

Section: Side Effectsmentioning

confidence: 99%

Molecular-Level Understanding of the Anticancer Action Mechanism of Anthracyclines

Shandilya¹,

Sharma²,

Das³

et al. 2021

Advances in Precision Medicine Oncology

View full text Add to dashboard Cite

show abstract

“…Under normal physiological conditions, the human body produces small amounts of ROS/RNS in the GI tract due to chemical reactions between oxygen and nitrogen components in the presence of acids or bile (Davies et al, 2011;Aviello and Knaus, 2018). ROS/RNS are oxidative species that can directly damage the DNA of microorganisms, thereby acting as a natural antimicrobial barrier.…”

Section: Reactive Oxygen and Nitrogen Speciesmentioning

confidence: 99%

The Impact of Protozoan Predation on the Pathogenicity of Vibrio cholerae

et al. 2020

View full text Add to dashboard Cite

In the aquatic environment, Vibrio spp. interact with many living organisms that can serve as a replication niche, including heterotrophic protists, or protozoa. Protozoa engulf bacteria and package them into phagosomes where the cells are exposed to low pH, antimicrobial peptides, reactive oxygen/nitrogen species, proteolytic enzymes, and low concentrations of essential metal ions such as iron. However, some bacteria can resist these digestive processes. For example, Vibrio cholerae and Vibrio harveyi can resist intracellular digestion. In order to survive intracellularly, bacteria have acquired and/or developed specific factors that help them to resist the unfavorable conditions encountered inside of the phagosomes. Many of these intra-phagosomal factors used to kill and digest bacteria are highly conserved between eukaryotic cells and thus are also expressed by the innate immune system in the gastrointestinal tract as the first line of defense against bacterial pathogens. Since pathogenic bacteria have been shown to be hypervirulent after they have passed through protozoa, the resistance to digestion by protist hosts in their natural environment plays a key role in enhancing the infectious potential of pathogenic Vibrio spp. This review will investigate the current knowledge in interactions of bacteria with protozoa and human host to better understand the mechanisms used by both protozoa and human hosts to kill bacteria and the bacterial response to them.

show abstract

“…38,39 PDGF is also known for stimulating the chemotaxis of neutrophils and macrophages which are crucial in the inflammatory phase of wound healing and produce ROS via nicotinamide adenine dinucleotide phosphate oxidase (NADPH oxidase). 40 PDGF could increase ROS production by stimulating the migration of immune cells and cytokines to the wound site and stimulate macrophages to produce growth factors which are critical for wound healing. 41…”

Section: The Function Of Platelet-derived Growth Factor(pdgf)mentioning

confidence: 99%