NAFLD and associated changes in serum Pro-hepcidin, Iron, Ferritin R levels and total iron binding capacity in weaning Rattus norvegicus

Abbas, AS; Abbasi, Muddasir Hassan; Sheikh, Nasreen M.

doi:10.1055/s-0032-1323970

Cited by 1 publication

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“…Non-alcoholic fatty liver disease (NAFLD) is among the most common causes of liver disorders worldwide (1)(2)(3)(4)(5), which may progress to nonalcoholic steatohepatitis (NASH) and hepatic cirrhosis (6)(7)(8)(9)(10)(11). NAFLD usually develops due to the accumulation of fatty acids in hepatocytes, which can progress to steatohepatitis through rise in oxidative stress in the body (6,12,13). Due to the rising prevalence of obesity and sedentary life, NAFLD has become the most common cause of chronic liver disease (14)(15)(16).…”

Section: Contextmentioning

confidence: 99%

Nigella sativa and Non-Alcoholic Fatty Liver Disease: A Review of the Current Evidence

2018

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Context: Nigella sativa (NS) has been used as an herbal remedy for the treatment and prevention of a variety of diseases. In this review, we aimed to summarize the current evidence on the effects of NS consumption on non-alcoholic fatty liver disease (NAFLD) characteristics. Evidence Acquisition: We reviewed the existing literature published by the end of 2017 using the following key words: "Nigella sativa", "black seeds", "black cumin", "thymoquinone", "NAFLD", "NASH", and "diabetes". Papers used in this study were collected by searching the PubMed, Google Scholar, Science Direct and Scopus databases. Our search was limited to English-language articles. All the articles published between 2000 and 2017 meeting the inclusion criteria were included in the study. Results: The results of current studies indicate that NS has many biological effects such as anti-inflammatory, anti-hyperlipidemic, anti-microbial, anti-cancer, anti-oxidative, anti-diabetic, anti-hypertensive and wound healing activities. In summary, it can be used as a valuable plant for designing therapeutic strategies in NAFLD. Conclusions: Results from available studies indicate that NS can ameliorate the main metabolic disturbances related to NAFLD including hyperglycemia, hyperlipidemia, and overweight. These effects are mainly attributed to the anti-oxidative and antiinflammatory properties of thymoquinone. Clinical trials on human subjects are highly essential to confirm the results found in in vivo and in vitro studies.

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