Nail Antioxidant Trace Elements Are Inversely Associated with Inflammatory Markers in Healthy Young Adults

Puchau, Blanca; Zulet, M. Ángeles; Hermsdorff, Helen Hermana Miranda; Navarro-Blasco, Í.; Martínéz, J. Alfredo

doi:10.1007/s12011-009-8443-5

Cited by 12 publications

(11 citation statements)

References 44 publications

(50 reference statements)

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“…Selenium is an essential antioxidant mineral, whereas its increased consumption has been inversely associated with pro-inflammatory markers [34,35] as well as with lower hypercholesterolemia [36,37] and lower LDL susceptibility to oxidation [38]. In addition, increased nail selenium levels also have been related to lower pro-inflammatory marker concentrations, such as complement C3 factor, asymmetric dimethylarginine, and interleukin-18 in young healthy adults [13,14,19]. According to previous and onset findings, it could speculate an inverse relationship between dietary selenium intake and the oxidation of LDL-c.…”

Section: Discussionmentioning

confidence: 99%

“…Fingernail and toenail samples were treated with sub-boiling nitric acid in a high-pressure teflon digestion vessel using a microwave digestion system (Ethos Plus, Millestone, Sorisole, Italy). Selenium (ng/g of nail), copper and zinc (μg/g of nail) concentrations were measured by a Perkin Elmer Analyst 800 atomic absorption spectrometer (Norwalk, CT, USA) as previously described [28,29]. …”

Section: Methodsmentioning

confidence: 99%

“…Thus, we measured plasma uric acid concentrations and glutathione peroxidase (GPx) activity in erythrocytes, since an altered regulation of these markers has been associated with ox-LDL concentrations in oxidative stress and chronic disorders conditions [11,12,17,18]. Also, we also assessed nail levels of three trace elements related to antioxidant defense mechanisms (selenium, zinc and cooper), whose levels have presented relevant associations with biomarkers in young adults [13,14,19]. …”

Section: Introductionmentioning

confidence: 99%

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Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study

et al. 2011

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BackgroundDespite oxidized low density lipoprotein (ox-LDL) plays important roles in the pro-inflammatory and atherosclerotic processes, the relationships with metabolic and oxidative stress biomarkers have been only scarcely investigated in young adult people. Thus, the aim of this study was to assess plasma ox-LDL concentrations and the potential association with oxidative stress markers as well as with anthropometric and metabolic features in healthy young adults.MethodsThis study enrolled 160 healthy subjects (92 women/68 men; 23 ± 4 y; 22.0 ± 2.9 kg/m2). Anthropometry, body composition, blood pressure, lifestyle features, biochemical data, and oxidative stress markers were assessed with validated tools. Selenium, copper, and zinc nail concentrations were measured by atomic absorption spectrophotometry.ResultsTotal cholesterol (TC), LDL-c and uric acid concentrations, TC-to-HDL-c ratio, and glutathione peroxidase (GPx) activity were positive predictors of ox-LDL concentrations, while nail selenium level (NSL) was a negative predictor, independently of gender, age, smoking status, physical activity. Those individuals included in the highest tertile of GPx activity (≥611 nmol/[mL/min]) and of NSL (≥430 ng/g of nail) had higher and lower ox-LDL concentrations, respectively, independently of the same covariates plus truncal fat or body mass index, and total cholesterol or LDL-c concentrations.ConclusionsOx-LDL concentrations were significantly associated with lipid biomarkers, GPx activity, uric acid concentration, and NSL, independently of different assayed covariates, in young healthy adults. These findings jointly suggest the early and complex relationship between lipid profile and redox status balance.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study

et al. 2011

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“…These studies showed a possible role for Se intake in the modulation of C3; its assessment may be an early marker of the MetS manifestations. [ 37 ] Nail content on some trace elements related to antioxidant defense mechanisms seems to be associated with several inflammation-related markers linked to chronic diseases in apparently healthy young adults,[ 38 ] negative and significant associations between MetS and Se intake. [ 39 ] ADMA seems to be related with Se status and several anthropometric and biochemical measurements linked to MetS in apparently healthy young adults.…”

Section: Resultsmentioning

confidence: 99%

A systematic review on the association of serum selenium and metabolic syndrome

et al. 2015

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Background:This systematic review paper aims to study the experimental and human studies on the relationship between metabolic syndrome (MetS), its component and selenium (Se) concentration.Materials and Methods:The literature was searched in PubMed, Scopus, and Google Scholar databases with no time limitation using MetS X and Se key words in medical subject heading. The related papers were selected in three phases. After quality assessment, two reviewers extracted the data, whereas the third reviewer checked their extracted data. All evidence comes from experimental and laboratory studies.Results:Finally, 18 articles were included. While, some studies documented that as an antioxidant agent, Se might be correlated with endothelial function, large controversy exists about the type of correlation including positive, negative, and no correlation between MetS and Se levels in body. Some of the reviewed studies were focused on antioxidant supplementation effects on MetS, results also varied in this regard.Conclusion:This inconsistency could be because of diversity in study design, population, lack of special focus on Se and MetS, and finally the complex nature of MetS.

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“…3 The relationship between antioxidant trace elements measured in the nail and the blood inflammatory markers' concentrations has been studied before. 4 Therefore, antioxidant intake may be linked to a reduction of the chronic low-grade inflammatory state seen in different metabolic syndromes. 4 In a recent study, Wang and colleagues 5 suggested that multivitamin and mineral supplementation, for example, zinc, could have blood pressure lowering effect and could reduce serum C-reactive protein (CRP) in the women studied.…”

Section: Dear Sirmentioning

confidence: 99%

Comment on:Does Zinc Supplementation Affect Inflammatory Markers in Hemodialysis Patients?

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Pakfetrat²,

Jahromi³

et al. 2011

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Nail Antioxidant Trace Elements Are Inversely Associated with Inflammatory Markers in Healthy Young Adults

Cited by 12 publications

References 44 publications

Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study

Relationship of oxidized low density lipoprotein with lipid profile and oxidative stress markers in healthy young adults: a translational study

A systematic review on the association of serum selenium and metabolic syndrome

Comment on:Does Zinc Supplementation Affect Inflammatory Markers in Hemodialysis Patients?

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