2002
DOI: 10.1016/s0378-5173(02)00321-6
|View full text |Cite
|
Sign up to set email alerts
|

Nail morphology studies as assessments for onychomycosis treatment modalities

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
37
0

Year Published

2007
2007
2021
2021

Publication Types

Select...
7
1

Relationship

0
8

Authors

Journals

citations
Cited by 44 publications
(37 citation statements)
references
References 37 publications
0
37
0
Order By: Relevance
“…The materials must meet the same levels of purity and safety as those prepared by traditional techniques. Most of the raw materials used in hot-melt extruded pharmaceuticals have been used in the production of other solid dosage forms such as tablets, pellets, granules, transdermal, and transmucosal systems (Aitken-Nichol et al, 1996;Munjal et al, 2006;Prodduturi et al, 2005;Repka et al, 1999aRepka et al, , 2000aRepka et al, , 2000bRepka et al, , 2001aRepka et al, , 2001bRepka et al, , 2002bRepka et al, , 2002cRepka et al, , 2006. Thermal stability of the individual compounds is a prerequisite for the process, although the short processing times encountered in this process may not limit all thermolabile compounds.…”
Section: Materials Used In Hot-melt Extrusionmentioning
confidence: 99%
See 2 more Smart Citations
“…The materials must meet the same levels of purity and safety as those prepared by traditional techniques. Most of the raw materials used in hot-melt extruded pharmaceuticals have been used in the production of other solid dosage forms such as tablets, pellets, granules, transdermal, and transmucosal systems (Aitken-Nichol et al, 1996;Munjal et al, 2006;Prodduturi et al, 2005;Repka et al, 1999aRepka et al, , 2000aRepka et al, , 2000bRepka et al, , 2001aRepka et al, , 2001bRepka et al, , 2002bRepka et al, , 2002cRepka et al, , 2006. Thermal stability of the individual compounds is a prerequisite for the process, although the short processing times encountered in this process may not limit all thermolabile compounds.…”
Section: Materials Used In Hot-melt Extrusionmentioning
confidence: 99%
“…65-80 (Crowley et al, 2002;McGinity et al, 1997;Repka et al, 1999a;Repka et al, 2000a;Repka et al, 2002b;Zhang, 1999) Poly(ethylene glycol) Carbowax ® -20 37-63 (Cuff et al, 1998;Forster et al, 2001c;Hamaura et al, 1999;Koleng et al, 1997;Perissutti et al, 2002;Repka et al, 2001c) Poly(vinyl pyrrolidone) Kollidon ® 168 - (Follonier et al, 1995;Forster et al, 2001a;Forster et al, 2001c;Hamaura et al, 1999;Hulsmann et al, 2001;Keleb et al, 2001) Poly ( (Miyagawa et al, 1996;Miyagawa et al, 1999;Sato et al, 1997) Ethylene-vinyl acetate copolymer plasticizers in producing solid dispersions by HME in addition to acting as solubilizers (Ghebremeskel et al, 2006). Additionally, several drug substances have been repo...…”
Section: Plasticizersmentioning
confidence: 99%
See 1 more Smart Citation
“…The current methods of treatment for onychomycosis have encountered only limited success, require long treatment duration, and risk systemic side effects (Rodgers and Bassler, 2001;Repka et al, 2002;Ajit et al, 2003). Approximately one-third of the patients cannot be completely cured after six or more weeks of oral medication due to treatment failure and relapse (Gupta and Shear, 1999;Gupta et al, 2001;Finch and Warshaw, 2007).…”
Section: Introductionmentioning
confidence: 99%
“…Current studies support the theory that topical therapies alone cannot effectively treat onychomycosis because of low-penetration rates of antifungal drugs through the nail plate (Baran & Kaoukhov, 2005;Lim et al, 2014); therefore, oral antifungal medications remain a mainstay in onychomycosis treatment because of the deep-seated and persistent nature of this type of infection. However, systemic treatment of onychomycosis is undesirable owing to the reported side effects of antifungal medications, the general immune-compromised nature of patients suffering from onychomycosis with higher incidence of drug interaction and hepatotoxicity, in addition to the limited blood circulation into the affected nail bed which necessitates the presence of large amount of the drug in the blood circulation (Repka et al, 2002;Miron et al, 2014). Therefore, the use of topical therapy for treatment of onychomycosis would circumvent the aforementioned systemic limitations (Hafeez et al, 2013) thereby, enhance patient compliance.…”
Section: Introductionmentioning
confidence: 99%