Nail psoriasis: An updated review of clinical reports on therapy and formulation aspects for topical delivery

Sharma, Vijay; Pathak, Kamla

doi:10.1016/j.jddst.2015.09.017

Cited by 4 publications

(3 citation statements)

References 106 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Methotrexate, cyclosporine and acitretin are used as conventional systemic treatment options. New biological agents such as adalimumab, entracept, infliximab and ustekinumab have also been indicated for nail psoriasis therapy [5,7,45]. Topical therapy can be a convenient alternative to oral therapy, being supported by the use of 5-fluorouracil, anthralin, tazarotene, cyclosporine, glucocorticosteroids (e.g., betamethasone, clobetasol propionate, fluocinolone acetonide and triamcinolone acetonide) and vitamin D3 [1,5].…”

Section: Nail Psoriasismentioning

confidence: 99%

“…In the case of onychomycosis and psoriasis in nails, the current standard of treatment is oral therapy due to the success rate [7,11]. However, in systemic treatments several aspects concerning therapeutical safety, such as side effects, drug interactions and risks associated with hepatic injury may limit their desirability, especially in the elderly population that is the most affected by comorbidities, being an obstacle for managing these diseases [3,[10][11][12].…”

Section: Limitations On Nail Treatmentsmentioning

confidence: 99%

See 1 more Smart Citation

Recent Patents on Permeation Enhancers for Drug Delivery Through Nails

Kreutz

Matos

Koester

2020

DDF

View full text Add to dashboard Cite

: The human nail is a unique barrier with a keratinized constitution that favors protection and fine touch. However, many disorders can affect the nail, among them, are the onychomycosis and psoriasis. Systemic oral therapy has been applied to treat these diseases, even presenting disadvantages, including side effects, drug interactions, contraindications, toxicity, high cost and low patient compliance. A great option to succeed in dealing with the problems associated with oral therapy is the topical administration of drugs. However, nail composition, low diffusion through ungual route and reduced tissue bioavailability for topical treatments are limiting factors. These drawbacks can be overcome by promoting penetration through the nails by employing penetration enhancers. The review focuses on patents that highlight permeation enhancers applied to nail drug delivery for the treatment of onychomycosis and psoriasis. Literature and patent searches were conduced regarding the topic of interest. The substantial literature and patent search revealed that permeation enhancers, especially chemicals, are great strategies for promoting the ungual delivery of drugs. Nail topical therapy containing permeation enhancers is an attractive option for delivering localized treatments.

show abstract

Section: Nail Psoriasismentioning

confidence: 99%

Section: Limitations On Nail Treatmentsmentioning

confidence: 99%

Recent Patents on Permeation Enhancers for Drug Delivery Through Nails

Kreutz

Matos

Koester

2020

DDF

View full text Add to dashboard Cite

show abstract

“…Nail pitting is the most common sign encountered in nail psoriasis (6)(7)(8). These changes are not specific and may also occur in other disorders (9).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic challenges in a case of psoriasis with nail onset

Mitran¹,

Mitran²,

Sârbu³

et al. 2017

J Mind Med Sci.

View full text Add to dashboard Cite

Nail psoriasis affects a large number of patients with psoriasis and has a major psychosocial impact. Furthermore, it may be regarded as a predictor of more severe forms of psoriasis and early sign of psoriatic arthritis. The clinical presentations vary depending on the structure affected (nail matrix or nail bed), the nail lesions may range from minor to severe, but they are not specific. Treatment is a challenge, in most cases the lesions being resistant to therapy. We present a rare case of psoriasis with nail onset in a 59-year-old woman. The nail involvement confined to the fingernails was severe, with significant impairment of the patient's quality of life. Conventional therapies failed to improve the nail lesions, but a marked improvement was achieved under etanercept therapy.Acne conglobata is a rare, severe form of acne vulgaris characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts, located on the face, trunk, neck, arms and buttocks. Case ReportWe report the case of a 16 year old Caucasian female patient from the urban area who addressed our Mădălina I. Mitran et al.

show abstract

Nail disorders in older people, and aspects of their pharmaceutical treatment

Murdan¹

2016

International Journal of Pharmaceutics

View full text Add to dashboard Cite

The aim of this paper was to explore how aging influences the nail unit, its disorders and its response to treatment, and to identify some of the age-related gaps in the ungual drug delivery literature. Aging causes obvious changes to the nail, some of which are inherently due to old age, while others are due to diseases/conditions which become more prevalent as we age. Alterations in the nail plate's colour, contour, thickness, fragility, surface features, cell size, chemical composition and growth rate are some of the changes, with toenails and fingernails showing different effects. With respect to disease, the incidence of onychomycosis - the most common nail disorder - is considerably higher in older people. Similarly, brittle nails become more common as we age. In contrast, the literature about aging and the incidence of nail psoriasis is inconclusive, although, it is clear that as one gets older, the negative impact of nail psoriasis on one's quality of life decreases. Pharmaceutical treatment of the diseases comprises local and systemic therapies, sometimes in combination. Systemic therapies have the inherent disadvantages of adverse systemic effects, drug interactions and the need for monitoring, disadvantages which are especially problematic for older people who are more likely to suffer from co-morbidities and be on other medications. Topical therapy avoids such disadvantages. However, the success rates of commercially available preparations are low, and older people may need help with their application. It is also proposed that regular inspection and grooming of nails should become part of routine care of older people, as these would provide opportunities to identify and treat any problems at an earlier stage.

show abstract

Nail psoriasis: An updated review of clinical reports on therapy and formulation aspects for topical delivery

Cited by 4 publications

References 106 publications

Recent Patents on Permeation Enhancers for Drug Delivery Through Nails

Recent Patents on Permeation Enhancers for Drug Delivery Through Nails

Therapeutic challenges in a case of psoriasis with nail onset

Nail disorders in older people, and aspects of their pharmaceutical treatment

Contact Info

Product

Resources

About