Therapeutic challenges in a case of psoriasis with nail onset

Abstract

Nail psoriasis affects a large number of patients with psoriasis and has a major psychosocial impact. Furthermore, it may be regarded as a predictor of more severe forms of psoriasis and early sign of psoriatic arthritis. The clinical presentations vary depending on the structure affected (nail matrix or nail bed), the nail lesions may range from minor to severe, but they are not specific. Treatment is a challenge, in most cases the lesions being resistant to therapy. We present a rare case of psoriasis with nail onset in a 59-year-old woman. The nail involvement confined to the fingernails was severe, with significant impairment of the patient's quality of life. Conventional therapies failed to improve the nail lesions, but a marked improvement was achieved under etanercept therapy.Acne conglobata is a rare, severe form of acne vulgaris characterized by the presence of comedones, papules, pustules, nodules and sometimes hematic or meliceric crusts, located on the face, trunk, neck, arms and buttocks. Case ReportWe report the case of a 16 year old Caucasian female patient from the urban area who addressed our Mădălina I. Mitran et al.

Correlation of Immunoglobulin G With Severity Of Psoriasis

“…18,19 Psoriasis is proposed to be an autoimmune ailment caused by improper activation of the cellular IgGanti-IgA antibody levels, modification in function of polymorph nuclear leukocytes reduces the no of T cells, and a rise in activity of beta cells. 2…”

“…1 The two peaks of onset of psoriasis are between the age 20 to 30 years and between the age of 50 to 60 Years and t equally in both sexes. 2 This ailment may be associated with various comorbidities including malignancy and cardiovascular problem. 3 The disease has poor impact on quality of life including impact on quality of life including the problems of anxiety, depression, stigma and in some cases suicidal deeds.…”

Comparison of Psoriasis Area and Severity Index (PASI) Scores in Patients Treated with Oral Methotrexate and A Combination of Oral Methotrexate and Narrow Band-Ultraviolet B (NB-UVB) Phototherapy

“…Research by Mitran et al in 2017 in Romania reported that psoriasis vulgaris could occur at any age, with the highest incidence in the age group of 15-30 years, and it rarely occurs before the age of 10 years. 12 The genetic role of human leukocyte antigen (HLA) class I, especially HLA-Cw6, is associated with earlier age onset and a family history of the positive ones. 13 In this study, the PASI score was found to be higher for females with an average of 18.40, compared to males with an average of 15.76.…”

Histological Study on the Possible Ameliorating Consequence of Blocking STAT-3 Pathway on Psoriasis Model in Adult Male Albino rat

“…Psoriasis is a chronic noncommunicable inflammatory skin disease affecting nearly 2% of the population with equal incidence in males and females [1] . This disease can affect any age, but its incidence is high in the 20s and 50s [2] . Due to its disfigurement effect, the patients often suffer from poor quality of life, depression and/or anxiety extending to the level of suicidal attempts [3,4] .…”