Nail Psoriasis, the unknown burden of disease

Klaassen, Karlijn M.G.; Kerkhof, P.C.M. van de; Pasch, Marcel C.

doi:10.1111/jdv.12368

Cited by 60 publications

(66 citation statements)

References 37 publications

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“…Patients filled in a Greek translation of both the DLQI (0-30) and NPQ10 (0-20) questionnaire. In our study, PASI was significantly correlated with DLQI, similar to published literature [1,9]. NPQ10 scores were converted to percentages.…”

Section: Quality Of Life and Severity Of Skin And Nail Involvement Insupporting

confidence: 86%

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Quality of life and severity of skin and nail involvement in patients with plaque psoriasis

Kyriakou

Patsatsi

Sotiriadis

2014

European Journal of Dermatology

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A. Various colour gradations as a dermatoscopic feature of cutaneous angiosarcoma of the scalp. Australas J Dermatol 2013; 54: 36-8. 2. Cuperus E, Leguit R, Albregts M, Toonstra J. Post radiation skin tumors: basal cell carcinomas, squamous cell carcinomas and angiosarcomas. A review of this late effect of radiotherapy. Eur J Dermatol 2013; 23: 749-57. 3. Ulbright TM, Clark SA, Einhorn LH. Angiosarcoma associated with germ cell tumors. Hum Pathol 1985; 16: 268-72. 4. Kim MK, Huh SJ, Kim DY, et al. Secondary angiosarcoma following irradiation-case report and review of the literature. Radiat Med 1998; 16: 55-60. 5. Idrees MT, Kuhar M, Ulbright TM, et al. Clonal evidence for the progression of a testicular germ cell tumor to angiosarcoma. Hum Pathol 2010; 41: 139-44. 6. Contreras AL, Punar M, Tamboli P, et al. Mediastinal germ cell tumors with an angiosarcomatous component: a report of 12 cases.

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Section: Quality Of Life and Severity Of Skin And Nail Involvement Insupporting

confidence: 86%

“…Psoriatic patients with nail disease have a significantly higher Psoriasis Area Severity Index (PASI) compared to those without [1]. Psoriatic patients with nail disease have a significantly higher Psoriasis Area Severity Index (PASI) compared to those without [1].…”

Section: Quality Of Life and Severity Of Skin And Nail Involvement Inmentioning

confidence: 99%

Quality of life and severity of skin and nail involvement in patients with plaque psoriasis

Kyriakou

Patsatsi

Sotiriadis

2014

European Journal of Dermatology

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“…Patients with (1) positive rheumatoid factor, (2) osteoarthritis (OA) of hands, (3) history of inflammatory bowel disease (nail dystrophy was commonly observed among them) [13], (4) gouty arthropathy (diagnosed by the presence of monosodium urate crystal in synovial fluid analysis or gouty tophi) and (5) those under treatment for nail onychomycosis were excluded.…”

Section: Exclusion Criteriamentioning

confidence: 99%

“…Wright et al described that distal interphalangeal (DIP) joint arthritis of hands with erosion and absorption of terminal phalanges as one of the common manifestations of PsA [3]. In view of the aggressive nature of PsA disease [4], it can lead to rapid deformities engulfing the respective finger and ultimately results in severe functional impairment leading to a poor quality of life [2,5,6].…”

Section: Introductionmentioning

confidence: 99%

Psoriatic nail involvement and its relationship with distal interphalangeal joint disease

et al. 2016

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Psoriatic nail disease and distal interphalangeal (DIP) arthritis both are common manifestations of psoriatic arthritis (PsA). Several clinical characteristics are allegedly associated with DIP joint damage, particularly nail psoriasis. However, there is little evidence to substantiate this phenomenon. The purpose of this study is to investigate the relationship between DIP involvement, nail psoriasis and other parameters. A cross-sectional study involved 45 patients from local rheumatology clinic. Four hundred fifty psoriatic fingernails scored, and the radiographs of all these fingers were reviewed to define PsA DIP arthritic changes. 64.4 % patients had nail psoriasis and 35.6 % had DIP arthritis. Univariate analysis identified that swollen joint-count, digits with chronic dactylitis, HLA-B27 status and nail psoriasis were associated with DIP arthritis. Regression model supported that nail disease was the most significant associated factor of DIP arthritis (OR 9.7, p = 0.05). Nail psoriasis was identified in 40.2 % of digits. Pitting (29.6 %), onycholysis (15.1 %), crumbling (8.2 %), nail bed hyperkeratosis (2.0 %) were noted with the mean modified Nail Psoriasis Severity Index of 0.95 +/-1.68. Among all digits, 57 had DIP arthritis while 393 did not. Within DIP joints with PsA radiological change, 59.6 % had nail disease. Chi-square test with the Bonferroni correction further supported an association between nail psoriasis and DIP involvement with p value of 0.001. Two specific nail subtypes-crumbling and onycholysis-were found to be significantly associated with DIP disease. A significant proportion of PsA patients had nail involvement and DIP arthritis. PsA patients with nail changes may be more susceptible to DIP disease.

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“…It often causes cosmetic problems and functional impairment, and may also be painful [10] . In a Dutch survey of 1,728 patients with nail psoriasis, 52% of the participants suffered from pain as a result of their disease, and many participants experienced impairment in their professional and private lives [11] .…”

Section: Introductionmentioning

confidence: 99%

Early Visible Improvements during K101-03 Treatment: An Open-Label Multicenter Clinical Investigation in Patients with Onychomycosis and/or Nail Psoriasis

Piraccini

Starace²,

Toft³

2017

Dermatology

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Introduction: Onychomycosis and nail psoriasis can be embarrassing to patients, so improving the appearance of affected nails should be one of the key short-term goals of treatment. Methods: An 8-week open-label multicenter study was conducted to assess whether K101-03, a marketed topical treatment containing propylene glycol, glycerol, urea, and lactic acid, could produce rapid cosmetic improvements in affected nails. Adult patients with a big toenail or thumbnail (the “target” nail) affected by onychomycosis (n = 72) or psoriasis (n = 34) or both (n = 1) applied K101-03 to their affected nails once a day for 8 weeks. During and after treatment, patients rated the overall appearance of their target nail on a 4-point scale. They also assessed whether thickening, discoloration, brittleness, and softness of the target nail had improved since baseline. Adverse events (AEs) that occurred between the first application of K101-03 and the end of treatment were recorded and categorized according to severity and relationship to K101-03. Results: After 8 weeks of K101-03 treatment, 92.2% of patients (95% confidence interval [CI] 87.06-97.40) reported at least some improvement in the target nail. After 1 week of treatment, 78.3% of patients with onychomycosis (95% CI 68.53-87.99) reported at least some improvement in the target nail, and 55.1% of them reported that discoloration of their target nail had improved. Three patients reported a total of 5 AEs, none of which were judged to be related to K101-03. Conclusions: In summary, K101-03 was well tolerated in patients with onychomycosis or nail psoriasis and rapidly improved their nails.

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Nail Psoriasis, the unknown burden of disease

Cited by 60 publications

References 37 publications

Quality of life and severity of skin and nail involvement in patients with plaque psoriasis

Quality of life and severity of skin and nail involvement in patients with plaque psoriasis

Psoriatic nail involvement and its relationship with distal interphalangeal joint disease

Early Visible Improvements during K101-03 Treatment: An Open-Label Multicenter Clinical Investigation in Patients with Onychomycosis and/or Nail Psoriasis

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