Nailfold Videocapillaroscopy in Patients with COVID-19-associated Pneumonia in Intensive Care Units

Karahan, Samet; Aydın, Kaniye; Çetinkaya, Ali; Sirakaya, Hatice Aslan

doi:10.29271/jcpsp.2022.04.455

Cited by 7 publications

(7 citation statements)

References 1 publication

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“…The alterations in capillary density and microvascular flow parameters were substantially comparable with the results of the patients with severe SARS-CoV-2 pneumonia admitted to the ICU but not subjected to VV-ECMO found by Damiani et al [37,39]. Furthermore, Carsetti et al found a relationship between D-dimer values and changes in capillary density, a finding also found by Karahan et al, in patients with severe COVID-19 admitted to intensive care, who were compared with a healthy control group [29].…”

Section: Nvc Vs Other Methods To Evaluate Microcirculationsupporting

confidence: 79%

“…In patients with acute SARS-CoV-2 infection, the main changes are an increase in capillary size (i.e., an enlarged capillary), although never the presence of true giant capillaries, together with edema, microhemorrhages, and thromboembolic phenomena [21,29]. The presence of hemosiderin deposits and capillary alterations are in keeping with the pathophysiological alterations of COVID-19 known to us today, in particular endothelium involvement [7,8].…”

Section: Discussionmentioning

confidence: 59%

“…This study examined a population with more severe infection than the patient cohort analyzed by Natalello et al However, a small number of patients who were not re-evaluated after hospital discharge were considered. Therefore, this analysis represents a single point in time in a small population; re-evaluation and the involvement of a larger number of subjects could provide more information [29].…”

Section: Microaneurysmsmentioning

confidence: 99%

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Microvascular Alteration in COVID-19 Documented by Nailfold Capillaroscopy

et al. 2023

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COVID-19 is a multisystemic disease that mainly affects and causes dysregulation of the endothelium, causing systemic manifestations. A nailfold video capillaroscopy is a safe, easy, and noninvasive method to evaluate microcirculation alteration. In this review, we analyzed the literature available to date regarding the object of nailfold video capillaroscopy (NVC) use in patients with a SARS-CoV-2 infection, both in the acute phase and after discharge. The scientific evidence pointed out the main alterations in capillary circulation shown by NVC, so reviewing the findings of each article allowed us to define and analyze the future prospects and needs for possibly including NVC within the management of patients with COVID-19, both during and after the acute phase.

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Section: Nvc Vs Other Methods To Evaluate Microcirculationsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 59%

Section: Microaneurysmsmentioning

confidence: 99%

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Microvascular Alteration in COVID-19 Documented by Nailfold Capillaroscopy

et al. 2023

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“…The lumen size of skin arterio-venous anastomoses (AVA) is regulated exclusively by neurogenic mechanisms, so we can assume that they also expand amidst the decrease of neurogenic tone. The dilation of AVA leads to arterio-venous shunting of the blood bypassing the capillary channel, which explains the significant decrease of I mn , a decrease of the number of functioning capillaries [13,14], reduction of perfusion (I m ) and venular overflow due to arterial blood discharge that in its turn leads to the dilation of venules [40,41] and a significant increase of the amplitude of respiratory-driven blood flow oscillations amplitude.…”

Section: Discussionmentioning

confidence: 99%

“…Despite the widespread prevalence of the disease and the incidence of cardiovascular complications, as well as the proven extensive involvement of microvasculature in pathological processes, only very few papers have been published to date on the noninvasive assessment of blood microcirculation after COVID-19 [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry

et al. 2023

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The present work is focused on the study of changes in microcirculation parameters in patients who have undergone COVID-19 by means of wearable laser Doppler flowmetry (LDF) devices. The microcirculatory system is known to play a key role in the pathogenesis of COVID-19, and its disorders manifest themselves long after the patient has recovered. In the present work, microcirculatory changes were studied in dynamics on one patient for 10 days before his disease and 26 days after his recovery, and data from the group of patients undergoing rehabilitation after COVID-19 were compared with the data from a control group. A system consisting of several wearable laser Doppler flowmetry analysers was used for the studies. The patients were found to have reduced cutaneous perfusion and changes in the amplitude–frequency pattern of the LDF signal. The obtained data confirm that microcirculatory bed dysfunction is present in patients for a long period after the recovery from COVID-19.

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Comparison of nailfold capillaroscopy findings in COVID-19 survivors with and without rheumatic disease: a case-control study

Kaplan,

Cengiz,

Şaş

et al. 2024

Cukurova Medical Journal

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Purpose: The aim of this study was to evaluate the nailfold capillaroscopy (NFC) findings of patients with rheumatic disease and healthy controls (HCs) who survived coronavirus disease 2019 (COVID-19). Materials and Methods: This study included patients with axial spondyloarthritis (axSpA), psoriatic arthritis (PsA), and rheumatoid arthritis (RA) who recovered from COVID-19 and HCs. NFC was performed for all participants. NFC findings of the three groups [patients with COVID-19 (group 1), HCs with COVID-19 (group 2), and HCs without COVID-19 (group 3)] were compared. Results: A total of 142 individuals (group 1, n = 42; group 2, n = 50; group 3, n = 50) were included in the study. Hospitalization and oxygen therapy were more common in group 1 than in group 2. The median time from a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-positive real-time polymerase chain reaction (RT-PCR) test to NFC was 10.3 (6.3–24.4) weeks in group 1 and 17.1 (6.1–44.9) weeks in group 2. All NFC findings did not differ among the groups except for capillary ramifications, which were higher in group 1 than in groups 2 and 3. Underlying rheumatic disease was the only predictor that was significantly associated with capillary ramifications. Conclusion: The NFC findings of COVID-19 survivors with and without rheumatic disease were substantially similar to those of HCs who did not have COVID-19. Capillary ramifications may result from an underlying rheumatic disease in patients with axSpA, PsA, and RA.

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Nailfold Videocapillaroscopy in Patients with COVID-19-associated Pneumonia in Intensive Care Units

Abstract: Objective: To compare patients with COVID-19 in intensive care units (ICUs) to healthy controls using nailfold videocapillaroscopy (NVC), offering standardised findings about micro-circulation.

Cited by 7 publications

References 1 publication

Microvascular Alteration in COVID-19 Documented by Nailfold Capillaroscopy

Microvascular Alteration in COVID-19 Documented by Nailfold Capillaroscopy

Assessment of Blood Microcirculation Changes after COVID-19 Using Wearable Laser Doppler Flowmetry

Comparison of nailfold capillaroscopy findings in COVID-19 survivors with and without rheumatic disease: a case-control study

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