2014
DOI: 10.2147/sar.s45666
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Nalmefene: a new approach to the treatment of alcohol dependence

Abstract: Reduction of alcohol consumption is not yet a widely accepted treatment objective for alcohol-dependent patients, as abstinence is often considered to be the only possible objective in this situation. However, various studies have demonstrated the value of proposing these two options to such patients. Firstly, reduction of alcohol consumption very significantly reduces the risk of alcohol-related damage, and also modifies the patient’s and the doctor’s perception of the disease, resulting in improved access to… Show more

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Cited by 37 publications
(27 citation statements)
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“…Non-selective opioid receptor antagonist alcoholism in a double-blind study (Grant et al, 2006) and PG (Paille and Martini, 2014) GABAergic system Topiramate GABA A agonist ICD (Bermejo, 2008) behavioral addictions: PG, binge eating. .…”
Section: Impulsivity and Addictions In General Populationmentioning
confidence: 99%
See 1 more Smart Citation
“…Non-selective opioid receptor antagonist alcoholism in a double-blind study (Grant et al, 2006) and PG (Paille and Martini, 2014) GABAergic system Topiramate GABA A agonist ICD (Bermejo, 2008) behavioral addictions: PG, binge eating. .…”
Section: Impulsivity and Addictions In General Populationmentioning
confidence: 99%
“…Naltrexone has been shown to be effective in reducing the abuse of nicotine (King et al, 2013), alcohol (Morgenstern et al, 2012), heroin and amphetamine (Adi et al, 2007;Tiihonen et al, 2012), and to treat PG (Grant et al, 2008), as well as improving altered sexual behavior (Bostwick and Bucci, 2008;Raymond et al, 2010). Nalmefene, an opioid receptor antagonist similar in both structure and activity to naltrexone, is also effective in alcoholism and PG in the general population (Grant et al, 2006;Paille and Martini, 2014).…”
Section: The Opioid Systemmentioning
confidence: 99%
“…Both are MOR antagonists and the latter is also a partial agonist of KOR (Paille and Martini, 2014;Wackernah et al, 2014). The efficacy of naltrexone for the treatment of alcoholism is only modest (Spanagel and Kiefer, 2008).…”
mentioning
confidence: 99%
“…Respondents were checked after the intensive treatment by the aftercare telephone monitoring. The patients were asked questions about abstinence/ sented as a new medical means to reduce the desire for alcohol but for now there is not enough experience of what will be its lasting effect (12).…”
Section: ) Overview Of the Studies Finally Included Is Presented As mentioning
confidence: 99%