NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis

Zhao, Xianxian; Gu, Chong; Cao, Yan; Zhang, Xiaolin; Li, Yang; Wang, Li; Ren, Lili; Zhang, Yan; Peng, Junyin; Zhu, Zhiming; Han, Yaling

doi:10.1155/2016/7395627

Cited by 16 publications

(11 citation statements)

References 42 publications

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“…CASP7 and CASP8 encode CASP7 and CASP8 proteins, respectively. SNPs can strongly influence plasma levels and the biological activities of their corresponding proteins [29]. A six-nucleotide insertion/deletion variant rs3834129, which is located in the CASP8 promoter region, is associated with decreased risk of various cancers including cutaneous melanoma [30–32].…”

Section: Discussionmentioning

confidence: 99%

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

Yao

Hao

Pei

2019

BioMed Research International

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Background. Abnormal apoptosis of keratinocytes is one of the pathological changes of psoriasis. Caspases (CASPs) are the central engines of apoptosis. Studies to date have shown that some SNPs alter the expression of related genes and lead to changes in disease risk. However, no studies have investigated the associations between gene polymorphisms and the risk of psoriasis in Han population in northeast China. Therefore, we conducted a case-control study to explore this question in Han population of northeastern China. Methods. 540 patients with PsV and 612 healthy age- and sex-matched controls were enrolled in this study. We determined the genotypes of 17 single nucleotide polymorphisms (SNPs) from 11 genes of caspase family by the improved multiplex ligation detection reaction (iMLDR) method. A model-based single SNP frequentist test and haplotype association studies were performed to evaluate the association between SNPs and PsV. Results. In the single SNP tests, rs6704688 in CASP8 was significantly associated with psoriasis vulgaris (PsV) in Han population of northeastern China (P = 0.0169, P’ = 0.0179 under the additive model; P = 0.0126, P’ = 0.0149 under the heterozygous model). In haplotype analyses, the CASP7 haplotype GC was found to be associated with PsV risk (case group versus control group, 47.2% versus 54.4%, respectively, p = 0.0149). Conclusions. Our study presented that the gene polymorphisms of CASP7 and CASP8 were significantly associated with PsV in Han population of northeastern China, which implied the functional relationship between PsV and caspase genes. CASP8 and CASP7 SNPs could be new potential biomarkers for risk stratification and prevention of PsV.

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Section: Discussionmentioning

confidence: 99%

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

Yao

Hao

Pei

2019

BioMed Research International

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“…Zhao and colleagues failed to find significant associations between NLRP3 polymorphism and predisposition to coronary heart disease in pre-hypertensive Chinese patients [70]. However, the cohort examined in this study was very limited.…”

Section: Expression Of Nlrp3 Inflammasome Components In Atherosclerotic Arteriesmentioning

confidence: 68%

NLRP3 inflammasome pathways in atherosclerosis

2017

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Atherosclerosis is the major cause of death and disability. Atherosclerotic plaques are characterized by a chronic sterile inflammation in the large blood vessels, where lipid-derived and damage-associated molecular patterns play important roles in inciting immune responses. Following the initial demonstration that NLR family Pyrin domain containing 3 (NLRP3) was important for atherogenesis, a substantial number of studies have emerged addressing the basic mechanisms of inflammasome activation and their relevance to atherosclerosis. In this review, we introduce the basic cellular and molecular mechanisms of NLRP3 inflammasome activation, and discuss the current findings and therapeutic strategies that target NLRP3 inflammasome activation during the development and progression of atherosclerosis.

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“…CARD8 is just one gene and contains no other genes. e polymorphism of CARD8 gene impacts its expression levels, and there is a large body of literature on CARD8 SNPs and their correlation with inflammasome protein expression and activation [24]. rs2043211 is the most studied susceptibility locus.…”

Section: Discussionmentioning

confidence: 99%

A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China

Pei

Liu

Hao

et al. 2020

BioMed Research International

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Caspase recruitment domain family member 8 (CARD8) is an adaptor molecule that negatively regulates nuclear factor-κB (NF-κB) activation, interleukin (IL)-1β secretion, and apoptosis. These play important roles in the pathogenesis of psoriasis. Genetic variants of CARD8 have been associated with an increased risk of several inflammatory diseases and psoriasis in Europe. However, nothing is known about the association of the polymorphisms of CARD8 and psoriasis vulgaris (PsV) in the Han population of northeastern China. To investigate the potential association between them, we designed a case-control study to genotype four selected single nucleotide polymorphisms (SNPs) using the improved multiplex ligation reaction (iMLDR) method. Model-based single SNP frequentist-test and haplotype association studies were performed to assess the association between SNPs and PsV. The results showed that the intron SNP rs10403848 was significantly associated with PsV (additive model p=0.0418, p′=0.0411, and statistical power 0.1902; heterozygous model p=0.0418, p′=0.0164, and statistical power 0.9406). A potential risk locus of nonsynonymous SNP rs2043211 found in the European population did not show a significant association in our study. We found that the polymorphism rs10403848 in CARD8 is significantly associated with PsV risk in the Han population of northeastern China. CARD8 may be involved in PsV in this population, as in the European population, but a different genetic process should be considered for the heterogeneity of risk loci.

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NALP3-Inflammasome-Related Gene Polymorphisms in Patients with Prehypertension and Coronary Atherosclerosis

Cited by 16 publications

References 42 publications

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

Association Study of the Caspase Gene Family and Psoriasis Vulgaris Susceptibility in Northeastern China

NLRP3 inflammasome pathways in atherosclerosis

A New Risk Polymorphism rs10403848 of CARD8 Significantly Associated with Psoriasis Vulgaris in Northeastern China

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