Naltrexone attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice

Wang, Zhiyuan; Guo, Liangkun; Han, Xiao; Song, Rui; Dong, Guangheng; Ma, Chunming; Wu, Ning; Li, Jin

doi:10.1016/j.bbr.2020.112971

Cited by 18 publications

(12 citation statements)

References 39 publications

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“…We considered the effect of feeding and coprophagy on colonic microbiota; therefore, we divided each group of mice into two cages and kept three mice in each cage. MA drug injection (intraperitoneal injection) was started for mice in the Ma and Ea groups as previously described [ 44 ]. MA drug injection (intraperitoneal injection) was administered at 1 mg/kg (dissolved in saline at 1 mg/mL) in the Ma and Ea groups for 7 days, and the conditioned place preference (CPP) validation experiment was conducted (drugs were provided by Sichuan Police College–Intelligent Policing Sichuan Provincial Key Laboratory).…”

Section: Methodsmentioning

confidence: 99%

“…The mice in group C were injected with 0.9% saline at the same time and in equal doses. MA dose selection was based on prior studies, and the 1-week dosing period chosen for the chronic regimen represents the average number of days/months of exposure observed in human chronic studies [ 44 ]. The total 1-week dose was chosen to fit the total daily/monthly use model in humans [ 45 ].…”

Section: Methodsmentioning

confidence: 99%

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Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Liang

Jin

et al. 2023

Metabolites

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This study aimed to investigate the changes in intestinal homeostasis and metabolism in mice after methamphetamine (MA) administration and exercise intervention. In this study, male C57BL/B6J mice were selected to establish a model of methamphetamine-induced addiction, and the gut microbiota composition, short-chain fatty acids (SCFAs), and amino acid levels were assessed by 16S rRNA, liquid chromatography–tandem mass spectrometry, and gas chromatography–tandem mass spectrometry, respectively. The results showed that 23 dominant microbiota, 12 amino acids, and 1 SCFA were remarkably higher and 9 amino acids and 6 SCFAs were remarkably lower in the exercise model group than in the control group. Among the top 10 markers with opposite trends between the exercise intervention group and model group, the differential microbiomes included Oscillibacter, Alloprevotella, Colidextribacter, Faecalibaculum, Uncultured, Muribaculaceae, and Negativibacillus; amino acids included proline; and SCFAs included isovaleric acid and pentanoic acid. Proline was negatively correlated with Negativibacillus and positively correlated with pentanoic acid. The results suggested that moderate-intensity aerobic exercise may modulate changes in the composition of the gut microbiota and the levels of amino acids and SCFAs induced by MA administration.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Liang

Jin

et al. 2023

Metabolites

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“…Eighteen mice were randomly assigned to the control group (C group, n = 6), methamphetamine control group (N-MA group, n = 6), and methamphetamine exercise group (E-MA group, n = 6). Mice in group C were injected with normal saline, and group N-MA and group E-MA were modeled for MA addiction according to previous literature [45]. MA was obtained from the Sichuan Key Laboratory of Intelligent Police, Sichuan Police College (Luzhou, China), and dissolved in 0.9% NaCl (saline).…”

Section: Experimental Designsmentioning

confidence: 99%

Effect of aerobic exercise on brain metabolite profiles in mice models of methamphetamine addiction: LC-MS-based metabolomics study

Zhu

et al. 2023

Preprint

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In recent years, an increasing number of studies have used metabolomics techniques to uncover the underlying mechanisms of diseases, including substance abuse. Although physical exercise has been considered as a potential treatment for methamphetamine (MA) abuse, there is still a lack of studies regarding exercise modulating the metabolic profile of the brain following MA use. This untargeted metabolomics study, based on liquid chromatography-mass spectrometry (LC-MS), investigated the effects of aerobic exercise on MA-induced metabolism in mice brain. We found that 2 weeks of treadmill training modulates MA-induced metabolic disturbances in the brain. Among these metabolites, 129 metabolites with significant differences were identified under MA induction, and 32 metabolites were significantly affected by exercise. The relevant differential metabolites were mainly enriched in glycerophospholipid metabolism, steroid hormone biosynthesis and degradation, and renin-angiotensin system pathways. To our knowledge, this is the first study to use LC-MS approach to explore the effects of aerobic exercise on MA-induced metabolic profiles in the brain. The findings of this study provide new insights into exercise therapy for MA use.

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“…Prior studies have demonstrated that the D1 receptor antagonist SCH23390 21 can suppress MA-induced CPP in rats, while the opioid antagonist naltrexone can attenuate MA CPP expression and MA priming-induced reinstatement of MA CPP in mice. 22 Additionally, alpha-2 adrenergic agonists like clonidine have been shown to block stress-induced reinstatement of heroin, 23 cocaine, 24 and nicotine 25 seeking in rodents. As such, we evaluated whether SCH23390, naltrexone, and clonidine have similar effects on MA CPP in zebrafish.…”

mentioning

confidence: 99%

Extinction and reinstatement of methamphetamine‐induced conditioned place preference in zebrafish

Chen,

Chan,

Chen

2023

Addiction Biology

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Conditioned place preference (CPP) paradigm in zebrafish has been used to measure drug reward, but there is limited research on CPP reinstatement to determine relapse vulnerability. The present study aimed to investigate extinction and reinstatement of methamphetamine (MA)‐induced CPP in zebrafish and evaluate the model's predictive validity. Zebrafish received different doses of MA (0–60 mg/kg) during CPP training. The preferred dose of MA at 40 mg/kg was used for extinction via either confined or nonconfined procedures. The extinguished CPP was reinstated by administering a priming dose of MA (20 mg/kg) or various stressors. To assess persistent susceptibility to reinstatement, MA CPP and reinstatement were retested following 14 days of abstinence. In addition, the effects of SCH23390, naltrexone, and clonidine on MA CPP during acquisition, expression, or reinstatement phases were monitored. MA induced CPP in a dose‐dependent manner. Both nonconfined and confined extinction procedures time‐dependently reduced the time spent on the MA‐paired side. A priming dose of MA, chasing stress, or yohimbine reinstated the extinguished CPP. After 14 days of abstinence, the MA CPP remained extinguished and was significantly reinstated by MA priming or chasing stress. Similar to the observations in rodents, SCH23390 suppressed the acquisition of MA CPP, naltrexone reduced the expression and MA priming‐induced reinstatement, while clonidine prevented stress‐induced reinstatement of MA CPP. This work expanded the zebrafish CPP paradigm to include extinction and reinstatement phases, demonstrating predictive validity and highlighting its potential as a valuable tool for exploring drug relapse.

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Naltrexone attenuates methamphetamine-induced behavioral sensitization and conditioned place preference in mice

Cited by 18 publications

References 39 publications

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Effect of Aerobic Exercise on Intestinal Microbiota with Amino Acids and Short-Chain Fatty Acids in Methamphetamine-Induced Mice

Effect of aerobic exercise on brain metabolite profiles in mice models of methamphetamine addiction: LC-MS-based metabolomics study

Extinction and reinstatement of methamphetamine‐induced conditioned place preference in zebrafish

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