Nano-Ag-loaded hydroxyapatite coatings on titanium surfaces by electrochemical deposition

Abstract

Hydroxyapatite (HA) coatings on titanium (Ti) substrates have attracted much attention owing to the combination of good mechanical properties of Ti and superior biocompatibility of HA. Incorporating silver (Ag) into HA coatings is an effective method to impart the coatings with antibacterial properties. However, the uniform distribution of Ag is still a challenge and Ag particles in the coatings are easy to agglomerate, which in turn affects the applications of the coatings. In this study, we employed pulsed electrochemical deposition to co-deposit HA and Ag simultaneously, which realized the uniform distribution of Ag particles in the coatings. This method was based on the use of a well-designed electrolyte containing Ag ions, calcium ions and L-cysteine, in which cysteine acted as the coordination agent to stabilize Ag ions. The antibacterial and cell culture tests were used to evaluate the antibacterial properties and biocompatibility of HA/Ag composite coatings, respectively. The results indicated the as-prepared coatings had good antibacterial properties and biocompatibility. However, an appropriate silver content should be chosen to balance the biocompatibility and antibacterial properties. Heat treatments promoted the adhesive strength and enhanced the biocompatibility without sacrificing the antibacterial properties of the HA/Ag coatings. In summary, this study provided an alternative method to prepare bioactive surfaces with bactericidal ability for biomedical devices.

Antimicrobial dental implant functionalization strategies —A systematic review

“…Some authors did not find a convincing decrease or even an increase in bacterial colonization on nanomaterials in comparison to untreated titanium 59,134,136,137) . Others found reductions in bacterial counts in vitro of up to 90% compared to commercially pure titanium on nano-Ti surfaces and of up to 100% for nano-AgHA when tested against E. coli, S. epidermidis and S. aureus [52][53][54][55][56]62,138) . It has recently been shown that a titanium nanotube surface exhibited antimicrobial properties and down-regulated the glycosyltransferase genes of S. mutans 171) .…”

“…It has recently been shown that a titanium nanotube surface exhibited antimicrobial properties and down-regulated the glycosyltransferase genes of S. mutans 171) . All studies that tested surfaces with a combination of nanostructures and organic or inorganic antimicrobial chemical compounds on the nano-level found reduced bacterial adhesion and viability 31,34,43,[59][60][61][62]97,135,137) . Surfaces containing Ag NPs show excellent biocidal activity towards P. aeruginosa, S. oralis, S. mutans, P. gingivalis, S. aureus 143,144) , S.…”

“…pneumoniae and E. coli 43,[59][60][61][62]108,143,144) . The evidence that nanoscale surfaces positively affect the cell response at the bone-implant interface and maintain cell proliferation capacity has encouraged the engineering of nanostructured dental implant surfaces 135,171) .…”

Antibiotic-decorated titanium with enhanced antibacterial activity through adhesive polydopamine for dental/bone implant

“…However, over recent years, there has been a marked increase in demand for implants, especially for dental and bone applications as a replacement for soft and hard tissue [2]. Titanium and titanium-based alloys with excellent properties (load-bearing, low density and biocompatibility) have been widely used as artificial implants in dental, bone replacement and orthopaedic surgery [3]. Nevertheless, there have been some cases of Ti implant failure [4][5][6], which are costly to rectify and are often distressing for the patients.…”

Surface Modification of Titanium and its Alloys for the Enhancement of Osseointegration in Orthopaedics

“…A bioactive hydroxyapatite (HA) coating can also be employed to assist osseointegration of orthopaedic implants 40 . Incorporating silver (Ag) into HA coatings is an active method to impart the coatings with antibacterial properties with good biocompatibility 41 . Ti-Nb-Hf alloy was coated with a number of small peptides like RGD (Arg-Gly-Asp)/PHSRN (Pro-His-Ser-Arg-Asn) and RGD (Arg-Gly-Asp)/FHRRIKA (Phe-His-Arg-ArgIle-Lys-Ala) and a comparative study was made with rat mesenchymal cells.…”