Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges

Rodríguez, Francisco; Caruana, Pablo; Fuente, Noa De la; Lloret, Pia Español; Gámez, María Rodríguez; Balart, J.; Llurba, Elisa; Rovira, Ramón; Ruiz, Raúl Ramírez; Martín-Lorente, Cristina; Corchero, José Luís; Céspedes, María Virtudes

doi:10.3390/biom12060784

Cited by 112 publications

(49 citation statements)

References 200 publications

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“…x int AuNP 8 calix water AuNP calix water (1) where E AuNP , E calix , and E water represent the optimized values of potential energy of AuNP, calixarene, and solvent in the bulk.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

“…Nanotechnology is an emerging strategy for more effective cancer treatment. 1 A nanostructure offers the benefit of especially accumulating in cancer tissues by exploiting the leaky nature of the tumor vasculature (enhanced permeability and retention effect) 2 or by binding receptors overexpressed on cancer cells (targeted anticancer therapy). 3 The anticancer activity preferentially localized in the desired sites of therapeutic action can improve therapeutic efficacy while decreasing the deleterious side effects of current chemotherapy.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Nanotechnology is an emerging strategy for more effective cancer treatment . A nanostructure offers the benefit of especially accumulating in cancer tissues by exploiting the leaky nature of the tumor vasculature (enhanced permeability and retention effect) or by binding receptors overexpressed on cancer cells (targeted anticancer therapy) .…”

Section: Introductionmentioning

confidence: 99%

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Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

Consoli¹,

Forte

Maugeri

et al. 2022

ACS Appl. Nano Mater.

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The development of novel chemical approaches for the fabrication of gold nanostructures with localized surface plasmon resonance (LSPR) falling in the near-infrared (NIR) region is one challenging topic in nanomaterials science. Due to their optical and photothermal properties triggered by light excitation in the therapeutic window (λ max = 650−1300 nm), gold-based nanostructures are appealing candidates in anticancer nanomedicine. Here, we report a novel method to prepare waterdispersible gold nanostructures with NIR-LSPR (λ max = 600−1000 nm) properties. The gold nanostructures were achieved in a single step by an unconventional method using NADH as a reducing agent and an amphiphilic choline-calix[4]arene derivative (Chol-Calix) forming micelles as a template. The CholCalix-Au nanostructures were characterized by UV−visible spectrophotometry, Raman spectroscopy, and atomic force microscopy. Agglomeration of the nanostructures due to multiple crosslinking interactions was observed and supported by modeling simulation. Effective anticancer photothermal-induced effect of the CholCalix-AuNPs was demonstrated on human breast cancer cells irradiated with biofriendly light at 808 nm.

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“…x int AuNP 8 calix water AuNP calix water (1) where E AuNP , E calix , and E water represent the optimized values of potential energy of AuNP, calixarene, and solvent in the bulk.…”

Section: ■ Experimental Sectionmentioning

confidence: 99%

Section: ■ Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

Consoli¹,

Forte

Maugeri

et al. 2022

ACS Appl. Nano Mater.

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“…Nanocomposites with shape-memory properties enable the fabrication of shape-programmable bone scaffolds [ 53 ]. Core–shell lipid-coated nanoparticles and nanodelivery systems of melittin can be used for cancer therapy [ 54 , 55 ]. Biodegradable nanoparticles hold promise for diabetes treatment [ 56 ].…”

Section: High-voltage Electrospinningmentioning

confidence: 99%

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

et al. 2022

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Oral ulcers affect oral and systemic health and have high prevalence in the population. There are significant individual differences in the etiology and extent of the disease among patients. In the treatment of oral ulcers, nanofiber films can control the drug-release rate and enable long-term local administration. Compared to other drug-delivery methods, nanofiber films avoid the disadvantages of frequent administration and certain side effects. Electrospinning is a simple and effective method for preparing nanofiber films. Currently, electrospinning technology has made significant breakthroughs in energy-saving and large-scale production. This paper summarizes the polymers that enable oral mucosal adhesion and the active pharmaceutical ingredients used for oral ulcers. Moreover, the therapeutic effects of currently available electrospun nanofiber films on oral ulcers in animal experiments and clinical trials are investigated. In addition, solvent casting and cross-linking methods can be used in conjunction with electrospinning techniques. Based on the literature, more administration systems with different polymers and loading components can be inspired. These administration systems are expected to have synergistic effects and achieve better therapeutic effects. This not only provides new possibilities for drug-loaded nanofibers but also brings new hope for the treatment of oral ulcers.

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“…In particular, the application of nanotechnology to the biomedical field can bring risks that nanotechnology can bring along with opportunities for new therapeutic and diagnostic technology development. In some cases, biomedical applications are considered due to the superior properties of nanomaterials but are no longer applied due to risk issues [ 1 , 2 , 3 ]. Carbon nanofibers (CNFs), defined as nanofibers composed of carbon, are widely used in commerce due to their broad range of applications [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

The Acute and Short-Term Inhalation of Carbon Nanofiber in Sprague-Dawley Rats

Jo¹,

Kim

et al. 2022

Biomolecules

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The inhalation toxicity of carbon nanofibers (CNFs) is not clearly known due to relatively few related studies reported. An acute inhalation study and short-term inhalation study (5 days) were therefore conducted using Sprague-Dawley rats. In the acute inhalation study, the rats were grouped and exposed to a fresh air control or to low (0.238 ± 0.197), moderate (1.935 ± 0.159), or high (24.696 ± 6.336 mg/m3) CNF concentrations for 6 h and thereafter sacrificed at 14 days. For the short-term inhalation study, the rats were grouped and exposed to a fresh air control or low (0.593 ± 0.019), moderate (2.487 ± 0.213), or high (10.345 ± 0.541 mg/m3) CNF concentrations for 6 h/day for 5 days and sacrificed at 1, 3, and 21 days post-exposure. No mortality was observed in the acute inhalation study. Thus, the CNF LC50 was higher than 25 mg/m3. No significant body or organ weight changes were noted during the 5 days short-term inhalation study or during the post-exposure period. No significant effects of toxicological importance were observed in the hematological, blood biochemical, and coagulation tests. In addition, the bronchoalveolar lavage (BAL) fluid cell differential counts and BAL inflammatory markers showed no CNF-exposure-relevant changes. The histopathological examination also found no CNF-exposure-relevant histopathological lesions. Thus, neither acute nor 5 days inhalation exposure to CNFs induced any noticeable toxicological responses.

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Nano-Based Approved Pharmaceuticals for Cancer Treatment: Present and Future Challenges

Cited by 112 publications

References 200 publications

Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

Near-Infrared-Responsive Choline-Calix[4]arene-Gold Nanostructures for Potential Photothermal Cancer Treatment

Advances in the Application of Electrospun Drug-Loaded Nanofibers in the Treatment of Oral Ulcers

The Acute and Short-Term Inhalation of Carbon Nanofiber in Sprague-Dawley Rats

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