Nano-based drug delivery system: a smart alternative towards eradication of viral sanctuaries in management of NeuroAIDS

Aggarwal, Nidhi; Sachin, .; Nabi, Bushra; Aggarwal, Sumit; Baboota, Sanjula; Ali, Javed

doi:10.1007/s13346-021-00907-8

Cited by 13 publications

(4 citation statements)

References 112 publications

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“…An exogenous loading technique is direct surface modification. In order to achieve target specificity, surface modifications such as chemical or genetic alterations are employed [ 94 ].…”

Section: Nanoparticle-based Oral Vaccination Strategiesmentioning

confidence: 99%

Recent Developments in Oral Delivery of Vaccines Using Nanocarriers

Zafar

Arshad²,

Rehman

et al. 2023

Vaccines

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As oral administration of vaccines is the preferred route due to its high patient compliance and ability to stimulate both cellular and humoral immune responses, it is also associated with several challenges that include denaturation of vaccine components in the acidic environment of the stomach, degradation from proteolytic enzymes, and poor absorption through the intestinal membrane. To achieve effective delivery of such biomolecules, there is a need to investigate novel strategies of formulation development that can overcome the barriers associated with conventional vaccine delivery systems. Nanoparticles are advanced drug delivery carriers that provide target-oriented delivery by encapsulating vaccine components within them, thus making them stable against unfavorable conditions. This review provides a detailed overview of the different types of nanocarriers and various approaches that can enhance oral vaccine delivery.

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“…An exogenous loading technique is direct surface modification. In order to achieve target specificity, surface modifications such as chemical or genetic alterations are employed [ 94 ].…”

Section: Nanoparticle-based Oral Vaccination Strategiesmentioning

confidence: 99%

Recent Developments in Oral Delivery of Vaccines Using Nanocarriers

Zafar

Arshad²,

Rehman

et al. 2023

Vaccines

View full text Add to dashboard Cite

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“…Other metallic nanoparticles with antiviral properties include titanium, zinc, and copper, as well as metal oxide nanoparticles like iron oxide, zinc oxide, and titanium dioxide. Others, such as platinum nanoparticles employed to detect influenza virus, have yet to be studied [60,61].…”

Section: Other Metallic Nanoparticlesmentioning

confidence: 99%

A Comprehensive Study of Recent Breakthroughs in the Management of Dynamic Viral Infections

SHARMA,

SINGH

2023

Int J Curr Pharm Sci

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Infectious diseases have been known to human civilization since the dawn of humanity. Infectious disorders are caused by various microorganisms (bacteria, fungi, and viruses). Viruses are the most well-known of all microbes. Viruses are the most well-known type of microbe. They are ultramicroscopic intracellular parasites that require a host cell to survive and reproduce. Viruses have either DNA or RNA as genetic material and have been linked to various diseases in humans, animals, and plants. The war between viruses and humans is ongoing, as both will employ diverse ways to oppose each other. Antiviral treatment and improved technology development a time-consuming process. Despite advanced instruments and tight quality control systems, only a few numbers of antiviral medications or treatment technologies are approved for human use. The cause could be side effects or antiviral medication resistance. Increased understanding of viruses, their infection mechanisms, and the rapid evolution of novel antiviral methods and methodologies will accelerate the creation of novel antiviral medications. This review focuses on the worldwide picture of drug discovery for infectious diseases and contemporary improved methodologies and antiviral therapy options.

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“…During these years, great progress has been made in the development of nano-drug delivery systems (NDDSs) (Fan et al, 2021;Rai et al, 2021). NDDSs are specially designed as drug delivery vehicles to deliver active pharmaceutical ingredients to their target locations, which have numerous advantages such as improved targeting, decreased toxicity and prolonged circulation time (Aggarwal et al, 2021).…”

Section: Introductionmentioning

confidence: 99%

The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

et al. 2022

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Polyethylene glycol is one of the most commonly used synthetic macromolecular polymers for modifying small molecule drugs, peptides, proteins or Nano-drug delivery systems to improve their water solubility, biocompatibility and stability.Block copolymers containing PEG have been widely used in Nano-drug delivery systems such as solid lipid nanoparticles, polymeric nanoparticles, polymeric micelles and liposomes. To date, although numerous PEGylated Nano-drug delivery systems have been developed, only a few have been approved for clinical application.Poor safety and effectivity are important reasons for the high failure of Nano-drug delivery systems clinical trials. These factors are not only related to the loaded drugs and released drugs, but also related to the nanocarriers. Therefore, investigating the in vivo spatiotemporal fate of block copolymers containing PEG used in Nano-drug delivery systems is necessary and important for evaluating their safety, efficacy and toxicity. In this article, we will review the information that has been reported about the absorption, distribution, metabolism and excretion of block copolymers containing PEG. We believe this review is helpful to understand the biological fate of block copolymers containing PEG.

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Nano-based drug delivery system: a smart alternative towards eradication of viral sanctuaries in management of NeuroAIDS

Cited by 13 publications

References 112 publications

Recent Developments in Oral Delivery of Vaccines Using Nanocarriers

Recent Developments in Oral Delivery of Vaccines Using Nanocarriers

A Comprehensive Study of Recent Breakthroughs in the Management of Dynamic Viral Infections

The In Vivo Pharmacokinetics of Block Copolymers Containing Polyethylene Glycol Used in Nanocarrier Drug Delivery Systems

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