Nano-Based Therapy for Treatment of Skin Cancer

Gilani, Sadaf Jamal; Jahangir, Mohammed Asadullah; Chandrakala,; Rizwanullah, Md.; Taleuzzaman, Mohamad; Shahab, Mohammad S.; Shakeel, Kashif; Aqil, Mohd.; Imam, Syed Sarim

doi:10.2174/1574891x13666180911095440

Cited by 13 publications

(3 citation statements)

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“…Essentially, this treatment would be localized to the interest of region, hopefully leaving surrounding normal tissue unaffected [115]. Lidocaine already comes in a topical/cream form, and topical chemotherapies are being investigated as new routes of treatment [116–118]. In some cases of oral and oropharynx SCC, we found that T2R14 expression is upregulated, indicating the potential of developing targeted therapies, on a case-by-case basis for this receptor [45].…”

Section: Discussionmentioning

confidence: 99%

Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Through Activation of Bitter Taste Receptor T2R14

Miller

Mueller

Holivert

et al. 2022

Preprint

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Head and Neck Squamous Cell Carcinomas (HNSCCs) have high mortality due to late stage diagnosis, high metastasis rates, and poor treatment options. Current therapies are invasive and aggressive, leading to a severe decline in patient quality of life (QoL). It is vital to create new therapies that are both potent and localized and/or targeted to prolong survival while maintaining QoL. Lidocaine is a local anesthetic used in HNSCC surgery settings. Lidocaine also activates bitter taste (taste family 2) receptor 14 (T2R14). T2Rs are G-protein coupled receptors (GPCRs) that increase intracellular Ca2+ when activated. T2Rs are expressed in mucosal epithelia, including internal regions of the head and neck, and are accessible drug targets. Here, we show that lidocaine increases intracellular Ca2+ and decreases cAMP in several HNSCC cell lines. Ca2+ release from the ER results in Ca2+ uptake into the mitochondria. Ca2+ mobilization is blocked with GPCR inhibitors and T2R14 antagonist, 6-methoxyflavanone. Lidocaine activation of T2R14 depolarizes the mitochondrial membrane, inhibits cell proliferation, and induces apoptosis. Lidocaine activates caspase-3 and -7 cleavage and also increases total caspase protein levels despite no changes in mRNA production. Both total and cleaved caspase products were upregulated even in the presence of cycloheximide, an inhibitor of protein synthesis. This suggests inhibition of the ubiquitin-proteasome system. It is vital to understand Lidocaine-induced apoptosis in HSNCCs to utilize its chemotherapeutic effects as a treatment option. In addition, future studies on T2R14 expression in HNSCC patients could provide insight for implementing lidocaine as a targeted topical therapy.

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Section: Discussionmentioning

confidence: 99%

Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Through Activation of Bitter Taste Receptor T2R14

Miller

Mueller

Holivert

et al. 2022

Preprint

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“…Thus, invention or discovery of novel therapy based on nanotechnology as the alternative is urgent . Given several existing review articles describing nanoformulations for skin cancer therapy, we herein included only a brief discussion to make the article whole. , Niu et al designed a peptide-conjugated cationic AuNP (AuPT) loaded pDNAs system (AuPT/Mi221) to inhibit the encoding of miRNA-221. As an efficient carrier of pDNAs, AuPT improved the transfection efficiency and reversed the progression of melanoma .…”

Section: Np-based Formulation For Skin Disordersmentioning

confidence: 99%

Nanodelivery Systems for Topical Management of Skin Disorders

et al. 2020

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Topical drug delivery has inherent advantages over other administration routes. However, the existence of stratum corneum limits the diffusion to small and lipophilic drugs. Fortunately, the advancement of nanotechnology brings along opportunities to address this challenge. Taking the unique features in size and surface chemistry, nanocarriers such as liposomes, polymeric nanoparticles, gold nanoparticles, and framework nucleic acids have been used to bring drugs across the skin barrier to epidermis and dermis layers. This article reviews the development of these formulations and focuses on their applications in the treatment of skin disorders such as acne, skin inflammation, skin infection, and wound healing. Existing hurdles and further developments are also discussed.

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“…Both lipophilic and hydrophilic drug molecules can be entrapped into liposomes in the lipid bilayer membrane, depending upon the categorized layer for therapeutics. Lipid soluble drugs get entrapped within the bi-layered lipidic membrane, while hydrophilic drugs get entrapped in the central aqueous core of the vesicles [57,58]. Liposomes are a potential carrier for controlled drug release of tumors therapeutic agents, antibiotics, for gene and antisense therapy through nucleic acid sequence delivery.…”

Section: Liposomesmentioning

confidence: 99%

Molecular Targets and Nanoparticulate Systems Designed for the Improved Therapeutic Intervention in Glioblastoma Multiforme

et al. 2020

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Glioblastoma multiforme (GBM) is the most aggressive and fatal CNS related tumors, which is responsible for about 4% of cancer-related deaths. Current GBM therapy includes surgery, radiation, and chemotherapy. The effective chemotherapy of GBM is compromised by two barriers, i. e., the blood-brain barrier (BBB) and the blood tumor barrier (BTB). Therefore, novel therapeutic approaches are needed. Nanoparticles are one of the highly efficient drug delivery systems for a variety of chemotherapeutics that have gained massive attention from the last three decades. Perfectly designed nanoparticles have the ability to cross BBB and BTB and precisely deliver the chemotherapeutics to GBM tissue/cells. Nanoparticles can encapsulate both hydrophilic and lipophilic drugs, genes, proteins, and peptides, increase the stability of drugs by protecting them from degradation, improve plasma half-life, reduce adverse effects and control the release of drugs/genes at the desired site. This review focussed on the different signaling pathways altered in GBM cells to understand the rationale behind selecting new therapeutic targets, challenges in the drug delivery to the GBM, various transport routes in brain delivery, and recent advances in targeted delivery of different drug and gene loaded various lipidic, polymeric and inorganic nanoparticles in the effective management of GBM.

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Nano-Based Therapy for Treatment of Skin Cancer

Cited by 13 publications

References 0 publications

Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Through Activation of Bitter Taste Receptor T2R14

Lidocaine Induces Apoptosis in Head and Neck Squamous Cell Carcinoma Through Activation of Bitter Taste Receptor T2R14

Nanodelivery Systems for Topical Management of Skin Disorders

Molecular Targets and Nanoparticulate Systems Designed for the Improved Therapeutic Intervention in Glioblastoma Multiforme

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