Nano Conjugated PLGA-Chlorambucil: Synthesis In Vitro Anti Non- Hodgkin's Lymphoma Cellular Assay

Akbarian, Saeed; Sojoodi, Jafar; Monnavari, Fatemeh; Heidari, Hassan; Khosravian, Pegah; Javar, Hamid Akbari; Assadi, Artin; Rasouli, Rahimeh; Saffari, Mostafa; Shandiz, Seyed Ataollah Sadat; Hejazinia, Hadi; Omoomi, Farnoor Davachi; Saffari, Mohammad; Ardestani, Mehdi Shafiee

doi:10.2174/1570180814666161130113446

Cited by 12 publications

(6 citation statements)

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“…Several factors that categorized in physical and chemical factors may affect drug delivery and the radiolabeling of a chemical compound (65)(66)(67)(68). For instance, pharmaceutical variables, such as sedimentation problems or instability of the cell chelator, choice of anticoagulant, level of stannous ion and oxidation of radiopharmaceuticals, difficulties with collecting sufficient cells, or problems may arise which are patient-related (drug interference or the presence of disease) can affect the radiolabeling and misdistribution of radiopharmaceuticals (69).…”

Section: Resultsmentioning

confidence: 99%

Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

2019

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Radiopharmaceuticals are drugs that contain radioisotopes used for diagnostic and therapeutic purposes. There are evidences that medicinal herbs and their constituents can modify the radiolabeling, biodistribution, and pharmacokinetics of radiopharmaceuticals through drug interaction. To have an overview of the effects and the underlying mechanisms of medicinal plants on the radiolabeling and bioavailability of radiopharmaceuticals, we conducted this study to summarize the current findings in this field. The scientific literature was systematically collected from databases and analyzed. Studies showed that medicinal plants and their constituents can alter radiolabeling and biodistribution via several mechanisms. Interactions with proteins in red blood cells at the same sites, chelating action of stannous and pertechnetate ions, antioxidant action impeding or decreasing stannous ion oxidation, direct oxidation of stannous ions, generation of reactive oxygen species (ROS) which oxidize stannous ions and damage induced in the cell membrane. Most the medicinal plants can decrease the radioactivity of radiopharmaceuticals, but some of them like Peumus boldus, Punica granatum, Nectandra membranacea, Mentha crispa, Rosmarinus officinalis and derivatives such as eugenol and epigallocatechin gallate have increasing effects. In addition, altering feature in some of them is tissue dependent.

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Section: Resultsmentioning

confidence: 99%

Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

2019

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“…Nanotechnology includes the development and use of nanoscale materials in terms of size and structure-dependent properties (Wang et al, 2020a,b). A nano-material is defined as 1 to 100 nm sized particles (Uludag et al, 2001;Roco, 2004;Kumar and Vijayalakshmi, 2006;Zhang and Uludag, 2009;Akbarian et al, 2017;Barhoum et al, 2017;El-Maghrabi et al, 2018;Jeevanandam et al, 2018). One of the prime aims of nanotechnology in the dental implant field is to increase osseointegration behavior (Coelho et al, 2009).…”

Section: Nanotechnology In Dental Implantsmentioning

confidence: 99%

A Brief Review on the Evolution of Metallic Dental Implants: History, Design, and Application

et al. 2021

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In recent years, significant advances in the field of medical materials have begun to emerge, especially in nanotechnology. The modern area of nanostructured implants possesses wide applications in various medical implants including their dental use. Nano-surface functions present substantial resolutions to medical obstacles through improved biomaterial proficiency, innovative dental-implant designs, and surface design procedures, such as nanoscale adhesive surfaces, bio-chemical anodization, and surface modification technique. This work covers dental implant history, nanotechnological advances, and its development that includes a description, basic properties, and the related results of composites and surface morphology, and the different types of nanomaterials used in dental implants. Significant attempts have been made over the last few decades to strengthen osteointegration and prevent bacterial attachment to the implant surfaces. The micro and nano-topography of the hierarchical surface orchestrate the biological reactions of implants and may solve the problems associated with implant-tissue issues. This research investigates the implant articles from 1964 to 2021, which offers a brief description of the nanostructured biomaterials to enhance dental implants’ performance and may open new frontiers in the advancement of implant technology.

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“…33 Another research aims to improve the activity of Chlorambucil through using poly (DL-lactide-co-glycolide) (PLGA) have shown PLGA-Chlorambucil has higher activity on the non-Hodgkin's lymphoma compared to the free drug. 34 Our work aimed to produce and characterize a new drug-IONPs. We produced Chloramb-CS-IONPs nanocomposite where IONP is as the core of the nanocomposite and the CS https://doi.org/10.2147/IJN.S312752…”

Section: Introductionmentioning

confidence: 99%

“…Different polymers were used to enhance the chlorambucil activity, which include poly (butyl cyanoacrylate), 31 linear-globular PEG, 32 hydroxychloroquine, 33 and poly (lactide-co-glycolide). 34 Chlorambucil-loaded poly (butyl cyanoacrylate) preparations have been shown to increase drug stability, thus avoiding drug hydrolysis. 31 In addition, Chlorambucil conjugated with anionic linear-globular dendrimer has decreased the insolubility of Chlorambucil in water and improved the anticancer activity in vitro and in vivo.…”

Section: Introductionmentioning

confidence: 99%

Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells

Hussein‐Al‐Ali

Hussein

Saifullah

et al. 2021

IJN

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Introduction: Traditional cancer therapies may have incomplete eradication of cancer or destroy the normal cells. Nanotechnology solves the demerit by a guide in surgical resection of tumors, targeted chemotherapies, selective to cancerous cells, etc. This new technology can reduce the risk to the patient and automatically increased the probability of survival. Toward this goal, novel iron oxide nanoparticles (IONPs) coupled with leukemia anti-cancer drug were prepared and assessed. Methods: The IONPs were prepared by the co-precipitation method using Fe +3 /Fe +2 ratio of 2:1. These IONPs were used as a carrier for chlorambucil (Chloramb), where the IONPs serve as the cores and chitosan (CS) as a polymeric shell to form Chloramb-CS-IONPs. The products were characterized using transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) analysis, Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM) analyses, and thermal gravimetric analysis (TGA). Results: The as-prepared IONPs were found to be magnetite (Fe 3 O 4 ) and were coated by the CS polymer/Chloramb drug for the formation of the Chloramb-CS-IONPs. The average size for CS-IONPs and Chloramb-CS-IONPs nanocomposite was found to be 15 nm, with a drug loading of 19% for the letter. The release of the drug from the nanocomposite was found to be of a controlled-release manner with around 89.9% of the drug was released within about 5000 min and governed by the pseudo-second order. The in vitro cytotoxicity studies of CS-IONPs and Chloramb-CS-IONPs nanocomposite were tested on the normal fibroblast cell lines (3T3) and leukemia cancer cell lines (WEHI). Chloramb in Chloramb-CS-IONPs nanocomposite was found to be more efficient compared to its free form. Conclusion:This work shows that Chloramb-CS-IONPs nanocomposite is a promising candidate for magnetically targeted drug delivery for leukemia anti-cancer agents.

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Nano Conjugated PLGA-Chlorambucil: Synthesis In Vitro Anti Non- Hodgkin's Lymphoma Cellular Assay

Cited by 12 publications

References 0 publications

Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

Effects of medicinal plants on radiolabeling and biodistribution of diagnostic radiopharmaceuticals: A systematic review

A Brief Review on the Evolution of Metallic Dental Implants: History, Design, and Application

Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells

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