Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review

Abstract

The oral cavity is an intricate environment subjected to various chemical, physical, and thermal injuries. The effectiveness of the local and systemically administered drugs is limited mainly due to their toxicities and poor oral bioavailability that leads to the limited effectiveness of the drugs in the target tissues. To address these issues, nanoparticle drug delivery systems based on metals, liposomes, polymeric particles, and core shells have been developed in recent years. Nano drug delivery systems have applications in the treatment of patients suffering from temporomandibular joint disorders such as preventing degeneration of cartilage in patients suffering from rheumatoid arthritis and osteoarthritis and alleviating the pain along with it. The antibacterial dental applications of nano-drug delivery systems such as silver and copper-based nanoparticles include these agents used to arrest dental caries, multiple steps in root canal treatment, and patients suffering from periodontitis. Nanoparticles have been used in adjunct with antifungals to treat oral fungal infections such as candida albicans in denture wearers. Acyclovir being the most commonly used antiviral has been used in combination with nanoparticles against an array of viral infections such as the herpes simplex virus. Nanoparticles based combination agents offer more favorable drug release in a controlled manner along with efficient delivery at the site of action. This review presents an updated overview of the recently developed nanoparticles delivery systems for the management of temporomandibular joint disorders along with the treatment of different oral infections.

Bench-to-bedside: Feasibility of nano-engineered and drug-delivery biomaterials for bone-anchored implants and periodontal applications

“…For instance, patients with certain health conditions that are experiencing unsuccessful treatments in oral regeneration. Therefore, acceleration of the healing process and the rise of antibacterial properties, associated with the development of personalized dental biomaterials, have been demonstrated to be the main focus of drug delivery biomaterials for oral tissue applications [ 4 , [131] , [132] , [133] ]. The translation of all current basic science into market products has a possibility for substantial improvements in oral treatments and general medicine.…”

Optimization of Technological Parameters of the Process of Forming Therapeutic Biopolymer Nanofilled Films

“…Lal et al [ 14 ] have found that combined NPs-based agents provide a more favourable release of drugs in a controlled manner and efficient delivery to the site of action. We hope that research will also contribute to the development of biopolymer nanofilled films used in dentistry, given their physicochemical properties, bioactivity and versatility.…”

“…Polymer nanomaterials, films, and coatings are widely used in various industries, including pharmaceuticals and medicine. Polymer tapes and films are used in equipment construction as working elements [ 1 , 2 ], to ensure the tightness of threaded joints during the life cycle of the product [ 3 , 4 ], for elastic fixation of broken bones during surgery on human limbs [ 5 , 6 ], for filtering liquids and gases [ 7 , 8 ], for aqueous nanostructures containing antimicrobials of natural origin have been developed to inactivate SARS-CoV-2 surrogates on surfaces [ 9 ], for wound healing [ 10 , 11 , 12 ] and dentistry [ 13 , 14 , 15 ].…”

Effect of microbubble as local drug delivery system in endodontic management - An In-Vitro study

“…In nanomedicine, microbubbles (MBs) have shown much promise in recent years because of their high encapsulation efficiency, targeted drug release, improved biocompatibility, and longer blood circulation time ( Zhou et al, 2010 , Lal et al, 2021 ). However, devices have to be designed to fabricate MBs at chair side.…”