Nano-drug delivery system for the treatment of multidrug-resistant breast cancer: Current status and future perspectives

Gao, Lanwen; Meng, Fansu; Yang, Zhenjiang; Lafuente-Merchan, Markel; Fernández, Laura Merino; Cao, Ye; Kusamori, Kosuke; Nishikawa, Makiya; Itakura, Shoko; Chen, Junqian; Huang, Xiaoxun; Ouyang, Dongfang; Riester, Oliver; Deigner, Hans-Peter; Lai, Haibiao; Pedraz, Jose Luis; Ramalingam, Murugan; Cai, Yu

doi:10.1016/j.biopha.2024.117327

Biomedicine & Pharmacotherapy

2024

DOI: 10.1016/j.biopha.2024.117327

|View full text |Cite

Nano-drug delivery system for the treatment of multidrug-resistant breast cancer: Current status and future perspectives

Lanwen Gao,

Fansu Meng,

Zhenjiang Yang

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article2

Relationship

Self Cite0

Independent2

Authors

Journals

Cited by 2 publications

References 141 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

Comprehensive review of drug resistance in mammalian cancer stem cells: implications for cancer therapy

Mengistu,

Tsegaw,

Demessie

et al. 2024

Cancer Cell Int

View full text Add to dashboard Cite

Cancer remains a significant global challenge, and despite the numerous strategies developed to advance cancer therapy, an effective cure for metastatic cancer remains elusive. A major hurdle in treatment success is the ability of cancer cells, particularly cancer stem cells (CSCs), to resist therapy. These CSCs possess unique abilities, including self-renewal, differentiation, and repair, which drive tumor progression and chemotherapy resistance. The resilience of CSCs is linked to certain signaling pathways. Tumors with pathway-dependent CSCs often develop genetic resistance, whereas those with pathway-independent CSCs undergo epigenetic changes that affect gene regulation. CSCs can evade cytotoxic drugs, radiation, and apoptosis by increasing drug efflux transporter activity and activating survival mechanisms. Future research should prioritize the identification of new biomarkers and signaling molecules to better understand drug resistance. The use of cutting-edge approaches, such as bioinformatics, genomics, proteomics, and nanotechnology, offers potential solutions to this challenge. Key strategies include developing targeted therapies, employing nanocarriers for precise drug delivery, and focusing on CSC-targeted pathways such as the Wnt, Notch, and Hedgehog pathways. Additionally, investigating multitarget inhibitors, immunotherapy, and nanodrug delivery systems is critical for overcoming drug resistance in cancer cells.

show abstract

Comprehensive review of drug resistance in mammalian cancer stem cells: implications for cancer therapy

Mengistu,

Tsegaw,

Demessie

et al. 2024

Cancer Cell Int

View full text Add to dashboard Cite

show abstract

Anticancer Potential of Tocopherols-Containing Plants and Semi-Synthetic Tocopherols

Sianipar,

Muflikhati,

Mangindaan

et al. 2024

Plants

View full text Add to dashboard Cite

Tocopherols, potent bioactive compounds with anticancer properties, remain understudied in herbal medicinal plants, presenting a significant knowledge gap in the field of natural anticancer agents. This review evaluates tocopherol-containing plants for their anticancer potential, analyzing Scopus publications from 2016 to 2024. Fifteen herbal medicinal plants were identified as promising candidates, including Bulbine anguistifolia Poelln, Punica granatum L., Moringa oleifera, Kigelia pinnata, and Typhonium flagelliforme Lodd. The review explores tocopherols’ anticancer mechanisms, including apoptosis induction and cell cycle arrest. Factors influencing tocopherols’ anticancer effects are examined, such as their forms (α, β, γ, δ), concentrations, plant parts utilized, and their stability in various plants. Additionally, emerging research on semi-synthetic tocopherol derivatives is analyzed, highlighting their potential as adjuvants in chemotherapy and their role in enhancing drug delivery and reducing side effects. This comprehensive analysis aims to advance the development of plant-based anticancer pharmaceuticals and improve cancer treatment strategies. By elucidating the mechanisms and potential of tocopherol-containing plants, this review provides a foundation for future research in plant-based anticancer therapies. It emphasizes the need for further investigation into these plants’ anticancer properties, potentially leading to novel, more effective, and less toxic cancer therapies. The findings presented here contribute to a nuanced understanding of how tocopherol-containing plants can be leveraged in the development of future anticancer drugs.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Nano-drug delivery system for the treatment of multidrug-resistant breast cancer: Current status and future perspectives

Cited by 2 publications

References 141 publications

Comprehensive review of drug resistance in mammalian cancer stem cells: implications for cancer therapy

Comprehensive review of drug resistance in mammalian cancer stem cells: implications for cancer therapy

Anticancer Potential of Tocopherols-Containing Plants and Semi-Synthetic Tocopherols

Contact Info

Product

Resources

About