Nano-drug delivery systems and their toxicological assessment

Marangoz, Özge; Yavuz, Oğuzhan

doi:10.5505/turkhijyen.2020.37790

Cited by 6 publications

(4 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Nonspecific distribution, uncontrolled biodegradability and toxicological side effects are the most important disadvantages of conventional drug delivery systems. To overcome these challenges, nanoparticles have been used as drug delivery systems for diagnostic and therapeutic purposes, particularly to enhance the pharmacodynamic properties of drugs and to drive their penetration into tissues at the molecular level [ 23 ]. Biocompatible and non-toxic nanomaterials are currently reported to be synthesized by various methods, and of course, not only the method but also the types and properties of the nanomaterials make it possible for them to be an advantageous pharmacological product [ 24 ].…”

Section: Nanomaterials As Drug Deliversmentioning

confidence: 99%

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Yeşilkır Baydar,

Ay,

Cakir Koc

2024

ADMET DMPK

View full text Add to dashboard Cite

Background and purpose: Cell biology approaches have gained a successful integration, development and application of nanotechnology with stem cell engineering and have led to the emergence of a new interdisciplinary field known as stem cell nanotechnology (SCN). Recent studies showed the potential and the advancement of developments for SCN applications in drug delivery systems. Cancer, neurodegenerative, muscle and blood diseases, cell and gene therapies, and tissue engineering and regenerative medicine applications are the important targets of SCN. Experimental approach: In this overview, we searched the literature using the common online websites for research and read the open access, full-text available articles since 2013. Key results: The studies vary according to the type of disease they targeted and the strategies they proposed, whether diagnostic or therapeutic. In addition to the use of stem cells, the utilisation of their membranes, secretomes, exosomes and extracellular vesicles with an appropriate nanotechnology strategy is also an aspect of the research. Conclusion: This brief overview of stem cell nanotechnology over the last ten years aims to provide insight into the frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems.

show abstract

Section: Nanomaterials As Drug Deliversmentioning

confidence: 99%

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Yeşilkır Baydar,

Ay,

Cakir Koc

2024

ADMET DMPK

View full text Add to dashboard Cite

show abstract

“…PAMAM-type dendrimers are frequently used as drug carrier systems, thanks to the high amount of primary amines and highly charged surface groups for proper conjugation. 103,104 Kumar and his colleagues prepared PAMAM (polyamidoamine) dendrimer formulations loaded with galantamine hydrobromide in order to improve the pharmacokinetic properties of galantamine hydrobromide and increase its uptake into the brain. In order to increase the amount of galantamine hydrobromide reaching the brain, bifunctional PAMAM dendrimeric formulations were prepared by conjugating vitamin C/PEG to the surface of PAMAM dendrimers.…”

Section: The Use Of Nanoscale Drug Delivery Systems In the Treatment ...mentioning

confidence: 99%

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

Ozceylan,

Sezgin-Bayindir

2024

ACS Omega

View full text Add to dashboard Cite

Neurodegenerative diseases, encompassing conditions such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, amyotrophic lateral sclerosis, prion disease, and Huntington's disease, present a growing health concern as human life expectancy increases. Despite this, effective treatments to halt disease progression remain elusive due to various factors, including challenges in drug delivery across physiological barriers like the blood−brain barrier and patient compliance issues leading to treatment discontinuation. In response, innovative treatment approaches leveraging noninvasive techniques with higher patient compliance are emerging as promising alternatives. This Review aims to synthesize current treatment options and the challenges encountered in managing neurodegenerative diseases, while also exploring innovative treatment modalities. Specifically, noninvasive strategies such as intranasal administration and nanosized drug delivery systems are gaining prominence for their potential to enhance treatment efficacy and patient adherence. Nanosized drug delivery systems, including liposomes, polymeric micelles, and nanoparticles, are evaluated within the context of outstanding studies. The advantages and disadvantages of these approaches are discussed, providing insights into their therapeutic potential and limitations. Through this comprehensive examination, this Review contributes to the ongoing discourse surrounding the development of effective treatments for neurodegenerative diseases.

show abstract

“…Lipozomların ilaç taşıma sistemi olarak sıkça tercih edilmesinin sebepleri arasında biyouyumlu ve non-iyonik olmaları, hem suda hem de yağda çözünebilir ilaçların taşınabilmesi, etkilerinin arttırılabilir olması, kapsülleme yoluyla stabilitelerinin arttırılabilmesi ve kapsüllenmiş ajanların toksisitelerinin azalmasını sağlamaları sayılabilmektedir. Ayrıca, toksik olmamaları ve kimyasal içeriklerinin belirlenebilmesi nedeniyle kanser araştırmalarında tercih edilmektedirler 22 . Lipozom içeren nanopartiküller vücut içine girdiklerinde antijen olarak algılanarak fagositik sistem tarafından temizlenirler ve vücut içine salınan ilacın dolaşımda kalma süresini ve etkisini azaltırlar 23 .…”

Section: Lipozomunclassified

Kanser Tedavisi İçin MikroRNA’ların Çok İşlevli Nano-taşıyıcılar İle Dağıtımı

Dağlioğlu

YÜKSEL

2023

Arşiv Kaynak Tarama Dergisi

View full text Add to dashboard Cite

Hücre proliferasyonu ve apoptozis gibi kanserden sorumlu biyolojik süreçlerde etkili olan miRNA’lar, farklı kanser türleri ve evrelerinin teşhis ve tedavisinde yeni biyobelirteçler olarak işlev görür. Bunun yanı sıra bazı miRNA’ların onkogen ve tümör baskılayıcı özelliği nanoteknoloji ile entegre edilmesiyle kanser oluşumunu engeller. Son yıllarda miRNA’ların kanser tedavisinde kullanılmasını sağlayan diğer bir yaklaşım ise nano-taşıyıcılardır. İlaçlar, peptitler veya genler gibi aktif bileşikleri taşımak için geliştirilen bu nano-taşıyıcıların kanser tedavisinde kullanımları umut vadetmektedir. Bu derleme, miRNA dağıtımında kullanılan nano-taşıyıcı türleri hakkında kısa bir bilgi sunmaktadır. Ayrıca nanoteknolojideki gelişmelerle birlikte miRNA’ların kanser teşhis ve tedavisinde kullanımın yanısıra gen susturma mekanizması olan RNA interferansından kısaca bahsedilmektedir.

show abstract

Nano-drug delivery systems and their toxicological assessment

Cited by 6 publications

References 0 publications

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Frontiers of stem cell engineering for nanotechnology-mediated drug delivery systems

Current Overview on the Use of Nanosized Drug Delivery Systems in the Treatment of Neurodegenerative Diseases

Kanser Tedavisi İçin MikroRNA’ların Çok İşlevli Nano-taşıyıcılar İle Dağıtımı

Contact Info

Product

Resources

About